RESUMEN

We introduce a novel and straightforward methodology for photoredox arylation of an indole scaffold using aryldiazonium salts under mild and metal-free conditions. Our approach enables the regioselective and chemoselective introduction of several aryl groups to the C(2) position of indoles and tryptophan, even in competition with other amino acids. This approach extends to the late-stage functionalization of peptides and lysozyme, heralding the unprecedented arylation of tryptophan residues in wild-type proteins and offering broad utility in chemical biology.

Asunto(s)

Indoles , Oxidación-Reducción , Triptófano , Triptófano/química , Indoles/química , Estructura Molecular , Procesos Fotoquímicos , Muramidasa/química , Péptidos/química , Estereoisomerismo , Catálisis