RESUMEN
The search for interventions to slow down and even reverse aging is a burgeoning field. The literature cites hundreds of supposedly beneficial pharmacological and genetic interventions in model organisms: mice, rats, flies and worms, where research into physiology is routinely accompanied by lifespan data. However, when experimental animals from one article live as long as controls from another article, comparing the results of interventions across studies can yield misleading outcomes. Theoretically, all lifespan data are ripe for re-analysis: we could contrast the molecular targets and pathways across studies and help focus the further search for interventions. Alas, the results of most longevity studies are difficult to compare. This is in part because there are no clear, universally accepted standards for conducting such experiments or even for reporting such data. The situation is worsened by the fact that the authors often do not describe experimental conditions completely. As a result, works on longevity make up a set of precedents, each of which might be interesting in its own right, yet incoherent and incomparable at least for the reason that in a general context, it may indicate, for example, not prolonging the life of an average organism, but compensating for any genetic abnormalities of a particular sample or inappropriate living conditions. Here we point out specific issues and propose solutions for quality control by checking both inter- and intra-study consistency of lifespan data.
Asunto(s)
Envejecimiento , Longevidad , Animales , Ratones , Ratas , Longevidad/genética , Envejecimiento/genética , Estándares de ReferenciaRESUMEN
The Open Genes database was created to enhance and simplify the search for potential aging therapy targets. We collected data on 2402 genes associated with aging and developed convenient tools for searching and comparing gene features. A comprehensive description of genes has been provided, including lifespan-extending interventions, age-related changes, longevity associations, gene evolution, associations with diseases and hallmarks of aging, and functions of gene products. For each experiment, we presented the necessary structured data for evaluating the experiment's quality and interpreting the study's findings. Our goal was to stay objective and precise while connecting a particular gene to human aging. We distinguished six types of studies and 12 criteria for adding genes to our database. Genes were classified according to the confidence level of the link between the gene and aging. All the data collected in a database are provided both by an API and a user interface. The database is publicly available on a website at https://open-genes.org/.
Asunto(s)
Envejecimiento , Bases de Datos Genéticas , Longevidad , Humanos , Envejecimiento/genética , Longevidad/genética , ARNRESUMEN
The search for interventions to slow down and even reverse aging is a burgeoning field. The literature cites hundreds of supposedly beneficial pharmacological and genetic interventions in model organisms: mice, rats, flies and worms, where research into physiology is routinely accompanied by lifespan data. Naturally the negative results are more frequent, yet scientifically quite valuable if analyzed systematically. Yet, there is a strong "discovery bias", i.e. results of interventions which turn out not to be beneficial remain unpublished. Theoretically, all lifespan data is ripe for re-analysis: we could contrast the molecular targets and pathways across studies and help focus the further search for interventions. Alas, the results of most longevity studies are difficult to compare. This is in part because there are no clear, universally accepted standards for conducting such experiments or even for reporting such data. The situation is worsened by the fact that the authors often do not describe experimental conditions completely. As a result, works on longevity make up a set of precedents, each of which might be interesting in its own right, yet incoherent and incomparable. Here we point out specific issues and propose solutions for quality control by checking both inter- and intra-study consistency of lifespan data.
RESUMEN
The behavior of supported alloyed and de-alloyed platinum-copper catalysts, which contained 14-27% wt. of Pt, was studied in the reactions of methanol electrooxidation (MOR) and oxygen electroreduction (ORR) in 0.1 M HClO4 solutions. Alloyed PtCux/C catalysts were prepared by a multistage sequential deposition of copper and platinum onto a Vulcan XC72 dispersed carbon support. De-alloyed PtCux-y/C catalysts were prepared by PtCux/C materials pretreatment in acid solutions. The effects of the catalysts initial composition and the acid treatment condition on their composition, structure, and catalytic activity in MOR and ORR were studied. Functional characteristics of platinum-copper catalysts were compared with those of commercial Pt/C catalysts when tested, both in an electrochemical cell and in H2/Air membrane-electrode assembly (MEA). It was shown that the acid pretreatment of platinum-copper catalysts practically does not have negative effect on their catalytic activity, but it reduces the amount of copper passing into the solution during the subsequent electrochemical study. The activity of platinum-copper catalysts in the MOR and the current-voltage characteristics of the H2/Air proton-exchange membrane fuel cell MEAs measured in the process of their life tests were much higher than those of the Pt/C catalysts.
RESUMEN
Gravitational-wave emission can lead to the coalescence of close pairs of compact objects orbiting each other1,2. In the case of neutron stars, such mergers may yield masses above the Tolman-Oppenheimer-Volkoff limit (2 to 2.7 solar masses)3, leading to the formation of black holes4. For white dwarfs, the mass of the merger product may exceed the Chandrasekhar limit, leading either to a thermonuclear explosion as a type Ia supernova5,6 or to a collapse forming a neutron star7,8. The latter case is expected to result in a hydrogen- and helium-free circumstellar nebula and a hot, luminous, rapidly rotating and highly magnetized central star with a lifetime of about 10,000 years9,10. Here we report observations of a hot star with a spectrum dominated by emission lines, which is located at the centre of a circular mid-infrared nebula. The widths of the emission lines imply that wind material leaves the star with an outflow velocity of 16,000 kilometres per second and that rapid stellar rotation and a strong magnetic field aid the wind acceleration. Given that hydrogen and helium are probably absent from the star and nebula, we conclude that both objects formed recently from the merger of two massive white dwarfs. Our stellar-atmosphere and wind models indicate a stellar surface temperature of about 200,000 kelvin and a luminosity of about 104.6 solar luminosities. The properties of the star and nebula agree with models of the post-merger evolution of super-Chandrasekhar-mass white dwarfs9, which predict a bright optical and high-energy transient upon collapse of the star11 within the next few thousand years. Our observations indicate that super-Chandrasekhar-mass white-dwarf mergers can avoid thermonuclear explosion as type Ia supernovae, and provide evidence of the generation of magnetic fields in stellar mergers.