Asunto(s)

Vasos Coronarios/metabolismo , Epoprostenol/metabolismo , Prostaglandinas/metabolismo , Receptores de Superficie Celular/metabolismo , Receptores de Prostaglandina/metabolismo , Alprostadil , Animales , Unión Competitiva , Bovinos , Iloprost , Prostaglandinas E/metabolismo , Receptores de Epoprostenol , Factores de Tiempo

RESUMEN

Sulprostone is a tissue-specific PGE2-derivative with high abortifacient activity in various species including man. The dissociation constant KD of the receptor binding of this compound was compared with PGE2 and PGF2 alpha in various tissue preparations of different species. A structure-binding relationship was developed from competition curves after a logit/log transformation. It is demonstrated that the relative affinities of Sulprostone, PGE2 and PGF2 alpha remain essentially constant in all the tissues investigated. It is concluded that the tissue-specificity of Sulprostone cannot be ascribed to structural differences of the receptor molecule.

Asunto(s)

Prostaglandinas/metabolismo , Receptores de Superficie Celular , Receptores de Prostaglandina , Animales , Fenómenos Químicos , Química , Cuerpo Lúteo/metabolismo , Dinoprostona/análogos & derivados , Femenino , Humanos , Mucosa Intestinal/metabolismo , Músculos/metabolismo , Embarazo , Prostaglandinas E/metabolismo , Prostaglandinas E Sintéticas/metabolismo , Prostaglandinas F/metabolismo , Ratas , Relación Estructura-Actividad , Útero/metabolismo