RESUMEN
We performed a fundamental study on levofloxacin (LVFX, DR-3355), a new synthetic antimicrobial agent, in the field of obstetrics and gynecology. Concentrations in serum and intrapelvic genital organs (various regions in the uterus, ovary and oviduct) were determined following single oral administration. The transport of LVFX into genital tissues was found to be good, with the tissue levels of 0.64-2.13 micrograms/g after oral administration of 100 mg and 0.77-4.86 micrograms/g after administration of 200 mg. These tissue levels of LVFX were higher than those in serum and exceeded the MIC90 values against most causative organisms isolated from the lesions of obstetric and gynecological infections. These data indicate that LVFX should be useful in the field of obstetrics and gynecology.
Asunto(s)
Levofloxacino , Ofloxacino/farmacocinética , Ovario/metabolismo , Útero/metabolismo , Administración Oral , Adulto , Femenino , Humanos , Persona de Mediana Edad , Ofloxacino/administración & dosificación , Ofloxacino/sangreRESUMEN
This paper describes a hip joint surgical simulation system using a three-dimensional image (X-ray CT images). We developed this system in cooperation with surgeons, and we have already applied it to several clinical examples. According to a surgeon who used our system for actual surgical plannings, most of the hip joint surgeries operated at the present time can be simulated. Our system has useful functions in order to plan surgeries such as interference check in movement of a bone and display of the attached surface of bone. We show an actual surgical planning process performed by the surgeon with our system.