RESUMEN

We report the identification of a novel major histocompatibility complex class I-related chain (MICB) allele, provisionally designated as MICB-0114 pending the WHO Nomenclature Classification for the MICB locus. This new allele is identical to MICB-0103101v except for a single mutation of G to A in exon 4 that translates into an amino acid substitution from glutamic acid to lysine.

Asunto(s)

Genes MHC Clase I , Proteínas/genética , Alelos , Sustitución de Aminoácidos , Secuencia de Bases , ADN/genética , Cartilla de ADN/genética , Exones , Antígenos de Histocompatibilidad Clase I , Humanos , Datos de Secuencia Molecular , Mutación Puntual , Reacción en Cadena de la Polimerasa , Homología de Secuencia de Ácido Nucleico

RESUMEN

We have identified a novel MICA allele, MICA*051, detected by the polymerase chain reaction using sequence-specific primers and characterized by sequence-based typing. MICA*051 appears to be the result of a recombination between MICA*00801 and MICA*00701 at intron 2.

Asunto(s)

Antígenos de Histocompatibilidad Clase I/genética , Alelos , Secuencia de Bases , Cartilla de ADN , Exones , Humanos , Intrones , Datos de Secuencia Molecular , Reacción en Cadena de la Polimerasa , Polimorfismo Genético