RESUMEN
Iron absorption in dogs without pancreatic secretion was studied measuring the percentage of radioactivity retained in red cells. Two groups were treated con 59Fe (5 microCi), given in the stomach: one group control and other undergoing pancreatic duct ligation. Increased absorption was observed in the last group. The influence of secretion on iron absorption, after administration of 60 mg of Fe (as ferrous sulphate solution pH 4.5), was also studied in three groups of dogs, treated with 18 Clinical Units of secretin. In one group, the pancreatic secretion was extracted from intestine by putting a catheter in the pancreatic duct. In the other two, the pancreatic duct remained normal, one with and other without the iron dose (control). A possible inhibitory effect of secretin on iron absorption was observed. Plasma Iron values remained without changes one hour after the iron administration, as well as TIBC, % saturation and transferrin values.
Asunto(s)
Absorción Intestinal , Hierro/metabolismo , Páncreas/metabolismo , Secretina/farmacología , Animales , Perros , Eritrocitos/metabolismo , Compuestos Ferrosos/metabolismo , Hierro/sangre , Radioisótopos de HierroRESUMEN
Iron absorption in dogs without pancreatic secretion was studied measuring the percentage of radioactivity retained in red cells. Two groups were treated con 59Fe (5 microCi), given in the stomach: one group control and other undergoing pancreatic duct ligation. Increased absorption was observed in the last group. The influence of secretion on iron absorption, after administration of 60 mg of Fe (as ferrous sulphate solution pH 4.5), was also studied in three groups of dogs, treated with 18 Clinical Units of secretin. In one group, the pancreatic secretion was extracted from intestine by putting a catheter in the pancreatic duct. In the other two, the pancreatic duct remained normal, one with and other without the iron dose (control). A possible inhibitory effect of secretin on iron absorption was observed. Plasma Iron values remained without changes one hour after the iron administration, as well as TIBC,
saturation and transferrin values.
RESUMEN
This study deals with the effects of iron overloading on total iron-binding capacity TIBC) in fasting subjects. Overloading was obtained by oral administration of 198 mg. ferrous gluconate. The method of Bothwell and Mallet was used for plasma iron determination; the Mg CO3 methods was used for TIBC. It was that normal subjects as well as hyperthyroid, hypothyroid goiter patients showed an increase of TIBC under these conditions. These results could be explained either on the basis of functional heterogeneity of transferrin bound iron, or of a new protein.