RESUMEN
An inverse radiation treatment planning algorithm for Sensus Healthcare's SculpturaTM electronic brachytherapy system has been designed. The algorithm makes use of simulated annealing to optimize the conformation number (CN) of the treatment plan. The highly anisotropic dose distributions produced by the SculpturaTM x-ray source empower the inverse treatment planning algorithm to achieve highly conformal treatment plans for a wide range of prescribed planning target volumes. Over a set of 10 datasets the algorithm achieved an average CN of 0.79 ± 0.08 and an average gamma passing rate of 0.90 ± 0.10 at 5%/5 mm. A regularization term that encouraged short treatment plans was used, and it was found that the total treatment time could be reduced by 20% with only a nominal reduction in the CN and gamma passing rate. It was also found that downsampling the voxelized volume (from 3203 to 643 voxels) prior to optimization resulted in a 150× speedup in the optimization time (from 2 + minutes to < 1 s) without affecting the quality of the treatment plan.
Asunto(s)
Braquiterapia , Planificación de la Radioterapia Asistida por Computador/métodos , Algoritmos , Anisotropía , Humanos , Masculino , Neoplasias de la Próstata/radioterapia , Dosificación RadioterapéuticaRESUMEN
Integrating porous networks in load-bearing implants is essential in order to improve mechanical compatibility with the host tissue. Additive manufacturing has enabled the optimisation of the mechanical properties of metallic biomaterials, notably with the use of novel periodic regular geometries as porous structures. In this work, we successfully produced solid and lattice structures made of Ti-25Ta alloy with selective laser melting (SLM) using a Schwartz primitive unit-cell for the first time. The manufacturability and repeatability of the process was assessed through macrostructural and microstructural observations along with compressive testing. The mechanical properties are found to be suitable for bone replacement applications, showing significantly reduced elastic moduli, ranging from 14 to 36â¯GPa depending on the level of porosity. Compared to the conventionally used biomedical Ti-6Al-4V alloy, the Ti-Ta alloy offers superior mechanical compatibility for the targeted applications with lower elastic modulus, similar strength and higher ductility, making the Ti-25Ta alloy a promising candidate for a new generation of load-bearing implants.
Asunto(s)
Aleaciones/química , Tantalio/química , Titanio/química , Soporte de Peso , Materiales Biocompatibles/química , Sustitutos de Huesos , Módulo de Elasticidad , Rayos Láser , Ensayo de Materiales , Microscopía Electrónica de Rastreo , Porosidad , Polvos , Prótesis e Implantes , Diseño de Prótesis , Estrés Mecánico , Propiedades de Superficie , Resistencia a la TracciónRESUMEN
Synthetic scaffolds are a highly promising new approach to replace both autografts and allografts to repair and remodel damaged bone tissue. Biocompatible porous titanium scaffold was manufactured through a powder metallurgy approach. Magnesium powder was used as space holder material which was compacted with titanium powder and removed during sintering. Evaluation of the porosity and mechanical properties showed a high level of compatibility with human cortical bone. Interconnectivity between pores is higher than 95% for porosity as low as 30%. The elastic moduli are 44.2GPa, 24.7GPa and 15.4GPa for 30%, 40% and 50% porosity samples which match well to that of natural bone (4-30GPa). The yield strengths for 30% and 40% porosity samples of 221.7MPa and 117MPa are superior to that of human cortical bone (130-180MPa). In-vitro cell culture tests on the scaffold samples using Human Mesenchymal Stem Cells (hMSCs) demonstrated their biocompatibility and indicated osseointegration potential. The scaffolds allowed cells to adhere and spread both on the surface and inside the pore structures. With increasing levels of porosity/interconnectivity, improved cell proliferation is obtained within the pores. It is concluded that samples with 30% porosity exhibit the best biocompatibility. The results suggest that porous titanium scaffolds generated using this manufacturing route have excellent potential for hard tissue engineering applications.