RESUMEN
Harmful algal blooms of the dinoflagellate Pyrodinium bahamense have caused human and economic losses in the last decades. This study, for the first time, documents a bloom of P. bahamense in the Red Sea. The alga was recurrently present in a semi-enclosed lagoon throughout nearly 2 years of observations. The highest cell densities (104-105cellsL-1) were recorded from September to beginning of December at temperatures and salinities of â¼26-32°C and â¼41, respectively. The peak of the bloom was recorded mid-November, before a sharp decrease in cell numbers at the end of December. Minimum concentrations in summer were at â¼103cellsL-1. A saxitoxin ELISA immunoassay of cultures and water samples confirmed the toxicity of the strain found in the Red Sea. Moreover, a gene expression analysis of the saxitoxin gene domain SxtA4 showed that transcript production peaked at the culmination of the bloom, suggesting a relation between transcript production, sudden cells increment-decline, and environmental factors.
Asunto(s)
Dinoflagelados/fisiología , Monitoreo del Ambiente , Saxitoxina/metabolismo , Estaciones del Año , Dinoflagelados/química , Perfilación de la Expresión Génica , Regulación de la Expresión Génica , Floraciones de Algas Nocivas , Océano Índico , Saxitoxina/genética , Agua de Mar , TemperaturaRESUMEN
BACKGROUND: Job satisfaction in doctors is related to migration, burnout, turnover and health service quality. However, little is known about their job satisfaction during economic recessions. Iceland and Norway have similar health care systems, but only Iceland was affected severely by the 2008 economic crisis. AIMS: To examine job satisfaction in Icelandic and Norwegian doctors, to compare job satisfaction with Icelandic data obtained before the current recession and to examine job satisfaction in response to cost-containment initiatives. METHODS: A survey of all doctors working in Iceland during 2010, a representative comparison sample of Norwegian doctors from 2010 and a historic sample of doctors who worked at Landspitali University Hospital in Iceland during 2003. The main outcome measure was job satisfaction, which was measured using a validated 10-item scale. RESULTS: Job satisfaction levels in Icelandic doctors (response rate of 61%, n = 622/1024), mean = 47.7 (SD = 10.9), were significantly lower than those of Norwegian doctors (response rate of 67%, n = 1025/1522), mean = 53.2 (SD = 8.5), after controlling for individual and work-related factors. Doctors at Landspitali University Hospital (response rate of 59%, n = 345/581) were less satisfied during the recession. Multiple regression analysis showed that cost-containment significantly affected job satisfaction (P < 0.001). CONCLUSIONS: Job satisfaction in doctors was lower in Iceland than in Norway, which may have been attributable partly to the current economic recession.
Asunto(s)
Recesión Económica , Satisfacción en el Trabajo , Médicos/estadística & datos numéricos , Estudios Transversales , Humanos , Islandia/epidemiología , Noruega/epidemiología , Médicos/economía , Médicos/psicología , Encuestas y CuestionariosRESUMEN
BACKGROUND: Population based studies have revealed varying mortality for patients with ulcerative colitis but most have described patients from limited geographical areas who were diagnosed before 1990. AIMS: To assess overall mortality in a European cohort of patients with ulcerative colitis, 10 years after diagnosis, and to investigate national ulcerative colitis related mortality across Europe. METHODS: Mortality 10 years after diagnosis was recorded in a prospective European-wide population based cohort of patients with ulcerative colitis diagnosed in 1991-1993 from nine centres in seven European countries. Expected mortality was calculated from the sex, age and country specific mortality in the WHO Mortality Database for 1995-1998. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated. RESULTS: At follow-up, 661 of 775 patients were alive with a median follow-up duration of 123 months (107-144). A total of 73 deaths (median follow-up time 61 months (1-133)) occurred compared with an expected 67. The overall mortality risk was no higher: SMR 1.09 (95% CI 0.86 to 1.37). Mortality by sex was SMR 0.92 (95% CI 0.65 to 1.26) for males and SMR 1.39 (95% CI 0.97 to 1.93) for females. There was a slightly higher risk in older age groups. For disease specific mortality, a higher SMR was found only for pulmonary disease. Mortality by European region was SMR 1.19 (95% CI 0.91 to 1.53) for the north and SMR 0.82 (95% CI 0.45-1.37) for the south. CONCLUSIONS: Higher mortality was not found in patients with ulcerative colitis 10 years after disease onset. However, a significant rise in SMR for pulmonary disease, and a trend towards an age related rise in SMR, was observed.
Asunto(s)
Colitis Ulcerosa/mortalidad , Adolescente , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , Enfermedades Cardiovasculares/mortalidad , Niño , Colitis Ulcerosa/tratamiento farmacológico , Colitis Ulcerosa/patología , Esquema de Medicación , Métodos Epidemiológicos , Europa (Continente)/epidemiología , Femenino , Fármacos Gastrointestinales/administración & dosificación , Enfermedades Gastrointestinales/mortalidad , Humanos , Israel/epidemiología , Enfermedades Pulmonares/mortalidad , Masculino , Persona de Mediana Edad , Neoplasias/mortalidad , Distribución por SexoRESUMEN
Faecal carriage of salmonella was investigated in 320 hedgehogs from Moss municipality in south-eastern Norway, Askøy, Bergen and Os municipalities in central-western Norway, and five municipalities in south-western and central Norway. The sampling in Moss was carried out 1 year after a human outbreak of salmonellosis, whereas the sampling in Askøy, Bergen and Os was carried out during a human outbreak. Both outbreaks were caused by Salmonella Typhimurium 4,5,12:i:1,2. No salmonella were detected in the hedgehogs from south-western (0/115) and central (0/24) Norway. Thirty-nine percent (39/99) of the animals sampled on Jeløy, and 41% (34/82) of those from Askøy, Bergen and Os, carried S. Typhimurium 4,5,12:i:1,2. The PFGE profile of isolates from hedgehogs and human beings were identical within each of the two outbreak areas. A significantly higher carrier rate of S. Typhimurium occurred among hedgehogs sampled at feeding places, compared to those caught elsewhere. The salmonella-infected hedgehog populations most likely constituted the primary source of infection during both of the human disease outbreaks, and the Norwegian hedgehog is suggested as a reservoir host of S. Typhimurium 4,5,12:i:1,2.
Asunto(s)
Brotes de Enfermedades , Reservorios de Enfermedades , Erizos/microbiología , Salmonelosis Animal/epidemiología , Infecciones por Salmonella/transmisión , Salmonella typhimurium/patogenicidad , Animales , Portador Sano , Heces/microbiología , Femenino , Humanos , Masculino , Noruega/epidemiología , Prevalencia , Infecciones por Salmonella/epidemiología , Salmonella typhimurium/aislamiento & purificación , ZoonosisAsunto(s)
Composición Corporal , Peso Corporal , Enfermedades de los Porcinos/patología , Mataderos , Animales , Noruega , PorcinosRESUMEN
Human orf is usually considered a rare disease caused by a virus belonging to the paravaccinia subgroup of pox viruses and transmitted to man from sheep and goats. This paper presents 119 new human cases with epidemiological, clinical, histopathological and ultrastructural findings. Erythema multiforme was found to be a common complication of human orf. Other complications tended to be caused by overtreatment. Electron microscopy of negatively stained suspensions from lesions was found to be the best and most rapid diagnostic method available.