RESUMEN

The aim of the present study was to assess the effect of serum calcium (Ca) status in the early postpartum period on the quantity and quality of colostrum, milk production, and the health of Holstein dams and their calves. One hundred multiparous Holstein cows were enrolled in this study. To determine serum Ca status, blood samples were taken at 1 and 4 days in milk (DIM). Cows were categorized into 1 of 4 groups based on their serum Ca concentrations: normocalcemic (CON; Ca >1.87 at 1 DIM and >2.10 mmol/L at 4 DIM, n = 36), transient SCH (TSCH; Ca ≤1.87 at 1 DIM and >2.10 mmol/L at 4 DIM, n = 14), persistent SCH (PSCH; Ca ≤1.87 at 1 DIM and ≤2.10 mmol/L at 4 DIM, n = 15), or delayed SCH (DSCH; Ca >1.87 at 1 DIM and ≤2.10 mmol/L at 4 DIM, n = 35). The ROC curve was utilized to determine the optimal cut-off value for serum total Ca, maximizing both sensitivity and specificity in predicting metritis. Metabolic disorders such as dystocia, retained placenta, and culling within 60 DIM were not affected by serum Ca status in the early postpartum period (P > 0.10). However, the incidences of metritis and endometritis were different based on the serum Ca status of the cows. The PSCH cows had a higher incidence of metritis than the CON cows (P = 0.05). Also, the DSCH cows tended to have an increased risk of metritis than the CON cows (P = 0.09). However, metritis incidence in the TSCH and CON cows was similar (P = 0.83). Cows with PSCH (P = 0.07) and DSCH (P = 0.10) tended to be at a higher risk for endometritis than the CON cows. But, the incidence of endometritis in the TSCH and CON cows was not different (P = 0.50). The TSCH cows had higher milk yield than the PSCH and DSCH cows (P = 0.05). However, milk yield was not different between the TSCH and CON cows and the PSCH and DSCH and CON cows. The serum Ca status of cows had no effect on colostrum volume and its quality, age and weight of weaning, and average daily gain of calves (P > 0.10). The proportion of calves experiencing failure of passive transfer (FPT) was greater in the PSCH group than in the CON group (P = 0.03). Also, the FPT tended to be higher in the DSCH calves compared to the CON calves (P = 0.10). However, the FPT in the TSCH and CON calves was not different (P = 0.83). The incidence of diarrhea tended to be higher in the PSCH and DSCH calves compared to the CON calves (P = 0.10). However, diarrhea incidence between the TSCH and CON calves was similar (P = 0.97). Overall, the findings of this study suggest that cows with TSCH showed better adaptation to lactation, experienced a lower occurrence of diseases and produced higher milk compared to PSCH and DSCH cows. Furthermore, despite the similar quantity and quality of colostrum across all groups, the PSCH and DSCH groups displayed a greater proportion of calves experiencing FPT and diarrhea in comparison to the TSCH group.

Asunto(s)

Calcio , Enfermedades de los Bovinos , Calostro , Hipocalcemia , Lactancia , Leche , Animales , Bovinos , Hipocalcemia/veterinaria , Femenino , Enfermedades de los Bovinos/sangre , Calcio/sangre , Leche/química , Embarazo , Animales Recién Nacidos , Periodo Posparto , Endometritis/veterinaria

RESUMEN

OBJECTIVES: There is a growing incidence of cognitive decline and dementia associated with the ageing population. Lifestyle factors such as diet, physical activity, and cognitive activities may individually or collectively be undertaken to increase one's odds of preventing cognitive decline and future dementia. This study will examine whether clinical trials using multidomain lifestyle intervention can significantly decrease the risk of cognitive decline and therefore dementia. DESIGN, SETTING AND PARTICIPANTS: This systematic literature review of multidomain lifestyle interventions for the prevention of cognitive decline and dementia followed the PRISMA guidelines. Clinical trials involving multidomain intervention (i.e., diet and physical activity, or without cognitive training) in older adults (≥ 49 years old) at higher risk of dementia were identified through 5 electronic databases (EMBASE, MEDLINE, CINAHL, Cochrane, and Scopus). A comprehensive search was performed to identify and retrieve publications until 15 November 2022. Trials were published in English. RESULTS: The included studies (n=15) assessed change in cognition in response to a multidomain lifestyle intervention. However, the cognitive outcome measures used in these studies were heterogeneous. Despite this heterogeneity, two thirds of the studies showed improvement in cognition following a multidomain intervention (n=10 with a total of 9,439 participants). However, five studies reported no improvement in cognition following the multidomain intervention. The most common form of dietary intervention included higher amount of fruit and vegetable intake; whole-grain cereal products instead of refined; low fat options in milk and meat products; and limiting sucrose intake to less than 50 g/day. Most clinical trial studies were powered to examining the effects of multidomain interventions in cognition but were not designed to test the contribution of individual domains (i.e., dietary changes, increased physical activity, or increased cognitive stimulation alone). CONCLUSION: This systematic review aimed to determine the effect of multimodal lifestyle interventions on cognitive outcomes in older adults at risk of dementia. We found that participants with conditions that may increase the risk of dementia, (e.g., hypertension, cardiovascular fragility) do benefit from multi-modal lifestyle changes including diet, physical activity, and cognitive training. Two thirds of studies using multidomain lifestyle interventions showed improvements in cognitive function. Trials with a focus on cognitive training, dietary improvement, and physical activity may prevent or delay cognitive decline in older adults including those at risk of developing dementia. Future studies should consider longer follow-up periods and adequate power to be able to examine the effects of each lifestyle component in the context of multimodal interventions.

Asunto(s)

Disfunción Cognitiva , Demencia , Humanos , Anciano , Disfunción Cognitiva/prevención & control , Cognición , Dieta , Estilo de Vida , Demencia/prevención & control

RESUMEN

Canopy cover is an important structural trait that is frequently used in forest inventories to assess sustainability as well as many other important aspects of forest stands. Remote sensing data is more effective and suitable for canopy cover estimating than traditional field measurements such as sample plots, especially at broad scales. Measurement and mapping this attribute in fine-scale is a difficult task. Aerial imagery using unmanned aerial vehicle (UAV) has been recognized as an excellent tool to estimate canopy attributes. In this study, we compared the potential of using digital hemispherical photography (DHP), digital cover photography (DCP), UAV RGB data, and canopy height model (CHM) for estimation of canopy cover of mix broad-leaved forest on seven different stands. The canopy cover was measured from two digital canopy photographic methods, including DHP (as the reference method) and DCP. The stand orthophotos were segmented using a multi-resolution image segmentation method. Afterward, the classification in two classes of the canopy cover and the non-canopy cover was conducted using minimum distance classification to estimate canopy cover. The CHM layer was generated based on the SfM algorithm and utilized in the canopy cover estimation in each stand as auxiliary data. The results showed a slight improvement when we used the CHM as auxiliary data. Overall, the results showed that the efficiency of the ground digital canopy photographic methods (zenith view) in multi-storied and dense forests is the lowest. In return, our method for digital aerial canopy photography (object-based canopy segmentation and classification) is simple, quick, efficient, and cost-effective.

Asunto(s)

Tecnología de Sensores Remotos , Árboles , Monitoreo del Ambiente , Bosques , Dispositivos Aéreos No Tripulados

RESUMEN

BACKGROUND: Age-related hearing loss (ARHL) is highly prevalent in older adults, and more than two-thirds above age of 70 years suffer from ARHL. Recent studies have established a link between ARHL and cognitive impairment; however, most of the studies have used verbally loaded cognitive measures to investigate the association between ARHL and cognition. It is possible that due to hearing impairment, the elderly may experience difficulty in following verbal instructions or completing tasks that heavily rely on hearing during cognitive assessments. This may result in overestimation of cognitive impairment in such individuals. This baseline cross-sectional study investigated the associations between untreated hearing loss and a number of cognitive functions using a battery of non-verbal cognitive tests. Further, association between hearing loss and psychological status of older adults was examined. STUDY DESIGN: Prospective case-controlled study. METHODS: A total of 119 participants (54 males, M=66.33±10.50 years; 65 females M=61.51±11.46 years) were recruited. All participants completed a hearing assessment, a computerised test battery of non-verbal cognitive functions and the depression, anxiety and stress scale. RESULTS: Hierarchical multiple regression analysis results revealed that hearing thresholds significantly associated with the working memory (P<0.05), paired associative learning scores (P<0.05), depression (P<0.001), and anxiety (P<0.001) and stress (P<0.001) scores. Analysis of covariance results revealed that participants with moderately-severe hearing loss performed significantly poorer in paired associative learning and working memory tasks and psychological function tests compared to those with normal hearing. CONCLUSION: Results of the current study suggest a significant relationship between ARHL and both cognition and psychological status. Our results also have some implications for using non-verbal cognitive tests to evaluate cognitive functions in post-lingually hearing impaired ageing adults, at least for those with more than moderately-severe levels of hearing loss.

Asunto(s)

Envejecimiento/fisiología , Trastornos del Conocimiento/etiología , Cognición/fisiología , Pérdida Auditiva/complicaciones , Percepción del Habla/fisiología , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Trastornos del Conocimiento/epidemiología , Trastornos del Conocimiento/fisiopatología , Estudios Transversales , Femenino , Pérdida Auditiva/epidemiología , Pérdida Auditiva/psicología , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Australia Occidental/epidemiología

RESUMEN

Ferritin, an iron storage and regulation protein, has been associated with Alzheimer's disease (AD); however, it has not been investigated in preclinical AD, detected by neocortical amyloid-ß load (NAL), before cognitive impairment. Cross-sectional analyses were carried out for plasma and serum ferritin in participants in the Kerr Anglican Retirement Village Initiative in Aging Health cohort. Subjects were aged 65-90 years and were categorized into high and low NAL groups via positron emission tomography using a standard uptake value ratio cutoff=1.35. Ferritin was significantly elevated in participants with high NAL compared with those with low NAL, adjusted for covariates age, sex, apolipoprotein E ɛ4 carriage and levels of C-reactive protein (an inflammation marker). Ferritin was also observed to correlate positively with NAL. A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished high from low NAL (area under the curve (AUC)=0.766), but was outperformed when plasma ferritin was added to the base model (AUC=0.810), such that at 75% sensitivity, the specificity increased from 62 to 71% on adding ferritin to the base model, indicating that ferritin is a statistically significant additional predictor of NAL over and above the base model. However, ferritin's contribution alone is relatively minor compared with the base model. The current findings suggest that impaired iron mobilization is an early event in AD pathogenesis. Observations from the present study highlight ferritin's potential to contribute to a blood biomarker panel for preclinical AD.

Asunto(s)

Péptidos beta-Amiloides/metabolismo , Ferritinas/sangre , Neocórtex/metabolismo , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/diagnóstico , Enfermedad de Alzheimer/genética , Apolipoproteína E4/genética , Biomarcadores/sangre , Proteína C-Reactiva/metabolismo , Estudios de Cohortes , Estudios Transversales , Femenino , Humanos , Masculino , Neocórtex/diagnóstico por imagen , Tamaño de los Órganos , Tomografía de Emisión de Positrones , Síntomas Prodrómicos , Sensibilidad y Especificidad

RESUMEN

Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer's disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on the exclusion of other causes of dementia. In addition, phase III clinical trials of potential treatments have mostly failed, leaving disease-modifying interventions elusive. AD can be characterised neuropathologically by the deposition of extracellular ß amyloid (Aß) plaques and intracellular accumulation of tau-containing neurofibrillary tangles. Disruptions in Aß metabolism/clearance contribute to AD pathogenesis. In vitro studies have shown that Aß metabolism is altered by curcumin, and animal studies report that curcumin may influence brain function and the development of dementia, because of its antioxidant and anti-inflammatory properties, as well as its ability to influence Aß metabolism. However, clinical studies of curcumin have revealed limited effects to date, most likely because of curcumin's relatively low solubility and bioavailability, and because of selection of cohorts with diagnosed AD, in whom there is already major neuropathology. However, the fresh approach of targeting early AD pathology (by treating healthy, pre-clinical and mild cognitive impairment-stage cohorts) combined with new curcumin formulations that increase bioavailability is renewing optimism concerning curcumin-based therapy. The aim of this paper is to review the current evidence supporting an association between curcumin and modulation of AD pathology, including in vitro and in vivo studies. We also review the use of curcumin in emerging retinal imaging technology, as a fluorochrome for AD diagnostics.

Asunto(s)

Enfermedad de Alzheimer/diagnóstico , Enfermedad de Alzheimer/prevención & control , Curcumina/farmacología , Animales , Cognición/efectos de los fármacos , Modelos Animales de Enfermedad , Colorantes Fluorescentes/análisis , Humanos , Ovillos Neurofibrilares/efectos de los fármacos , Ovillos Neurofibrilares/metabolismo , Fármacos Neuroprotectores/farmacología , Nootrópicos/farmacología , Ensayo de Unión Radioligante/métodos , Ensayos Clínicos Controlados Aleatorios como Asunto

RESUMEN

Individual biological differences may contribute to the variability of outcomes, including cognitive effects, observed following electroconvulsive treatment (ECT). A narrative review of the research literature on carriage of the apolipoprotein E ɛ4 allele (APOE-ɛ4) and the protein biomarker beta amyloid (Aß) with ECT cognitive outcome was undertaken. ECT induces repeated brain seizures and there is debate as to whether this causes brain injury and long-term cognitive disruption. The majority of ECT is administered to the elderly (over age 65 years) with drug-resistant depression. Depression in the elderly may be a symptom of the prodromal stage of Alzheimer's disease (AD). Carriage of the APOE-ɛ4 allele and raised cerebral Aß are consistently implicated in AD, but inconsistently implicated in brain injury (and related syndromes) recovery rates. A paucity of brain-related recovery, genetic and biomarker research in ECT responses in the elderly was found: three studies have examined the effect of APOE-ɛ4 allele carriage on cognition in the depressed elderly receiving ECT, and two have examined Aß changes after ECT, with contradictory findings. Cognitive changes in all studies of ECT effects were measured by a variety of psychological tests, making comparisons of such changes between studies problematic. Further, psychological test data-validity measures were not routinely administered, counter to current testing recommendations. The methodological issues of the currently available literature as well as the need for well-designed, hypothesis driven, longitudinal studies are discussed.

Asunto(s)

Péptidos beta-Amiloides/genética , Apolipoproteína E4/genética , Trastorno Depresivo/genética , Trastorno Depresivo/terapia , Terapia Electroconvulsiva , Anciano , Anciano de 80 o más Años , Péptidos beta-Amiloides/metabolismo , Animales , Apolipoproteína E4/metabolismo , Encéfalo/metabolismo , Trastorno Depresivo/metabolismo , Femenino , Marcadores Genéticos/genética , Humanos , Masculino , Pruebas Neuropsicológicas

RESUMEN

The aim of this paper was to investigate the association of three well-recognised dietary patterns with cognitive change over a 3-year period. Five hundred and twenty-seven healthy participants from the Australian Imaging, Biomarkers and Lifestyle study of ageing completed the Cancer Council of Victoria food frequency questionnaire at baseline and underwent a comprehensive neuropsychological assessment at baseline, 18 and 36 months follow-up. Individual neuropsychological test scores were used to construct composite scores for six cognitive domains and a global cognitive score. Based on self-reported consumption, scores for three dietary patterns, (1) Australian-style Mediterranean diet (AusMeDi), (2) western diet and (3) prudent diet were generated for each individual. Linear mixed model analyses were conducted to examine the relationship between diet scores and cognitive change in each cognitive domain and for the global score. Higher baseline adherence to the AusMeDi was associated with better performance in the executive function cognitive domain after 36 months in apolipoprotein E (APOE) ɛ4 allele carriers (P<0.01). Higher baseline western diet adherence was associated with greater cognitive decline after 36 months in the visuospatial cognitive domain in APOE ɛ4 allele non-carriers (P<0.01). All other results were not significant. Our findings in this well-characterised Australian cohort indicate that adherence to a healthy diet is important to reduce risk for cognitive decline, with the converse being true for the western diet. Executive function and visuospatial functioning appear to be particularly susceptible to the influence of diet.

Asunto(s)

Trastornos del Conocimiento/epidemiología , Dieta , Anciano , Envejecimiento/genética , Envejecimiento/psicología , Apolipoproteína E4/genética , Australia , Trastornos del Conocimiento/genética , Estudios de Cohortes , Función Ejecutiva , Femenino , Estudios de Seguimiento , Humanos , Modelos Lineales , Masculino , Pruebas Neuropsicológicas , Análisis de Componente Principal , Encuestas y Cuestionarios

RESUMEN

Physical exercise interventions and cognitive training programs have individually been reported to improve cognition in the healthy elderly population; however, the clinical significance of using a combined approach is currently lacking. This study evaluated whether physical activity (PA), computerized cognitive training and/or a combination of both could improve cognition. In this nonrandomized study, 224 healthy community-dwelling older adults (60-85 years) were assigned to 16 weeks home-based PA (n=64), computerized cognitive stimulation (n=62), a combination of both (combined, n=51) or a control group (n=47). Cognition was assessed using the Rey Auditory Verbal Learning Test, Controlled Oral Word Association Test and the CogState computerized battery at baseline, 8 and 16 weeks post intervention. Physical fitness assessments were performed at all time points. A subset (total n=45) of participants underwent [(18)F] fluorodeoxyglucose positron emission tomography scans at 16 weeks (post-intervention). One hundred and ninety-one participants completed the study and the data of 172 participants were included in the final analysis. Compared with the control group, the combined group showed improved verbal episodic memory and significantly higher brain glucose metabolism in the left sensorimotor cortex after controlling for age, sex, premorbid IQ, apolipoprotein E (APOE) status and history of head injury. The higher cerebral glucose metabolism in this brain region was positively associated with improved verbal memory seen in the combined group only. Our study provides evidence that a specific combination of physical and mental exercises for 16 weeks can improve cognition and increase cerebral glucose metabolism in cognitively intact healthy older adults.

Asunto(s)

Envejecimiento/fisiología , Glucosa/metabolismo , Memoria Episódica , Actividad Motora/fisiología , Corteza Sensoriomotora/fisiología , Aprendizaje Verbal/fisiología , Anciano , Anciano de 80 o más Años , Envejecimiento/metabolismo , Terapia Combinada , Fluorodesoxiglucosa F18 , Humanos , Masculino , Persona de Mediana Edad , Tomografía de Emisión de Positrones , Radiofármacos , Corteza Sensoriomotora/metabolismo , Terapia Asistida por Computador/métodos , Resultado del Tratamiento

RESUMEN

The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P = 0.01 and P = 0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments.

Asunto(s)

Enfermedad de Alzheimer/complicaciones , Enfermedad de Alzheimer/diagnóstico , Enfermedades de la Retina/complicaciones , Enfermedades de la Retina/diagnóstico , Anciano , Análisis de Varianza , Australia , Biomarcadores , Encéfalo/diagnóstico por imagen , Estudios de Cohortes , Progresión de la Enfermedad , Diagnóstico Precoz , Femenino , Humanos , Masculino , Fotograbar/métodos , Placa Amiloide/diagnóstico por imagen , Tomografía de Emisión de Positrones/métodos , Reproducibilidad de los Resultados , Arteria Retiniana , Vena Retiniana

RESUMEN

Numerous studies have reported positive impacts of physical activity on cognitive function. However, the majority of these studies have utilised physical activity questionnaires or surveys, thus results may have been influenced by reporting biases. Through the objective measurement of routine levels of physical activity via actigraphy, we report a significant association between intensity, but not volume, of physical activity and cognitive functioning. A cohort of 217 participants (aged 60-89 years) wore an actigraphy unit for 7 consecutive days and underwent comprehensive neuropsychological assessment. The cohort was stratified into tertiles based on physical activity intensity. Compared with individuals in the lowest tertile of physical activity intensity, those in the highest tertile scored 9%, 9%, 6% and 21% higher on the digit span, digit symbol, Rey Complex Figure Test (RCFT) copy and Rey Figure Test 30-min recall test, respectively. Statistically, participants in the highest tertile of physical activity intensity performed significantly better on the following cognitive tasks: digit symbol, RCFT copy and verbal fluency test (all P<0.05). The results indicate that intensity rather than quantity of physical activity may be more important in the association between physical activity and cognitive function.

Asunto(s)

Cognición/fisiología , Ejercicio Físico/fisiología , Actividad Motora/fisiología , Actigrafía , Anciano , Anciano de 80 o más Años , Estudios de Cohortes , Ejercicio Físico/psicología , Femenino , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas

RESUMEN

The presence of olfactory dysfunction in individuals at higher risk of Alzheimer's disease has significant diagnostic and screening implications for preventive and ameliorative drug trials. Olfactory threshold, discrimination and identification can be reliably recorded in the early stages of neurodegenerative diseases. The current study has examined the ability of various olfactory functions in predicting cognitive decline in a community-dwelling sample. A group of 308 participants, aged 46-86 years old, were recruited for this study. After 3 years of follow-up, participants were divided into cognitively declined and non-declined groups based on their performance on a neuropsychological battery. Assessment of olfactory functions using the Sniffin' Sticks battery indicated that, contrary to previous findings, olfactory discrimination, but not olfactory identification, significantly predicted subsequent cognitive decline (odds ratio = 0.869; P<0.05; 95% confidence interval = 0.764-0.988). The current study findings confirm previously reported associations between olfactory and cognitive functions, and indicate that impairment in olfactory discrimination can predict future cognitive decline. These findings further our current understanding of the association between cognition and olfaction, and support olfactory assessment in screening those at higher risk of dementia.

Asunto(s)

Enfermedad de Alzheimer/diagnóstico , Discriminación en Psicología , Trastornos del Olfato/diagnóstico , Olfato , Anciano , Anciano de 80 o más Años , Agnosia/diagnóstico , Agnosia/psicología , Enfermedad de Alzheimer/genética , Enfermedad de Alzheimer/psicología , Apolipoproteína E4/genética , Apolipoproteínas E/genética , Estudios de Cohortes , Progresión de la Enfermedad , Femenino , Genotipo , Humanos , Vida Independiente/psicología , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas/estadística & datos numéricos , Odorantes , Trastornos del Olfato/psicología , Valor Predictivo de las Pruebas , Psicometría , Reconocimiento en Psicología , Umbral Sensorial

RESUMEN

We examined the sequence of a 2214 base pair HindIII fragment from the mitochondrial genome of six rainbow trout. The fragment encodes four proteins and two tRNAs. Sequences for two fish from a single locality were identical. Those from separate localities differed by from 1 to 7 nucleotide substitutions. Of 13 variable sites, 12 were synonymous and 1 led to a conservative amino acid substitution. Transitions accounted for 12 of the 13 variants. In contrast to interspecific comparisons (Thomas and Beckenbach. 1989. J. Mol. Evol. 29: 233-245), the intraspecific divergence estimates based on sequence are less than those estimated from restriction fragment analysis, suggesting a complex, dynamic process for the accumulation of variation in the mitochondrial genome.

Asunto(s)

ADN Mitocondrial/genética , Variación Genética , Salmonidae/genética , Trucha/genética , Secuencia de Aminoácidos , Animales , Secuencia de Bases , Codón , Exones , Datos de Secuencia Molecular , Homología de Secuencia de Ácido Nucleico