RESUMEN
The authors investigated the effect of thymectomy and TP2 thymic polypeptide extract administration on total, esterified and free cholesterol in the plasma and the adrenals, as well as on plasma Na and K and plasma free total 11-hydroxycorticosteroids. The results showed that total, esterified and free cholesterol decrease in the adrenals by 23.20%, 28.57% and 17.70% maximum respectively, in the thymectomized rat and that under the influence of the TP2 extract the values increase by 14.81%, 15.38% and 12.67%, respectively. Plasma cholesterol did not change. Thymectomy caused an increase in the plasma 11-hydroxycorticosteroids value by 13.4% and administration of the TP2 extract lowered their value by 58.11%. The plasma Na and K values did not change.
Asunto(s)
11-Hidroxicorticoesteroides/sangre , Colesterol/sangre , Potasio/sangre , Sodio/sangre , Extractos del Timo/farmacología , Timo/fisiología , Animales , Masculino , Peso Molecular , Péptidos/farmacología , Ratas , Ratas Endogámicas , TimectomíaRESUMEN
The effects of Atrazine (a herbicide of the Triazines class) in doses of 100 ppm on the circadian rhythms of RNA, DNA and total protein in the thyroid and adrenal were studied on 60 adult white Wistar male rats as against the controls. Atrazine affected the circadian rhythms of these indexes differently, in relation to the index and to the specific endocrine tissue. These alterations point to changes in the regulation systems of endocrine secretion in the two glands studied.