RESUMEN
BACKGROUND: Lassa fever (LF) is one of the most devastating rodent-borne diseases in West Africa, causing thousands of deaths annually. The geographical expansion of LF is also a concern; cases were recently identified in Ghana and Benin. Previous ecological studies have suggested that high natural-host biodiversity reduces the likelihood of spillover transmission of rodent-borne diseases, by suppressing the activities of reservoir species. However, the association of biodiversity with the geographical expansion of LF has not been the subject of epidemiological studies. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a spatial analysis based on sociodemographic, geographical, and ecological data, and found that higher rodent species richness was significantly associated with a lower risk of LF emergence in West Africa from 2008 to 2017 (Odds Ratio = 0.852, 95% Credible Interval = 0.745-0.971). CONCLUSIONS/SIGNIFICANCE: The results reinforce the importance of the 'One Health' approach by demonstrating that a high level of biodiversity could benefit human health.
Asunto(s)
Reservorios de Enfermedades/virología , Fiebre de Lassa/transmisión , Fiebre de Lassa/veterinaria , Roedores/virología , África Occidental , Animales , Benin , Biodiversidad , Brotes de Enfermedades , Geografía , Ghana , Humanos , Virus Lassa , Salud Única , Enfermedades de los Roedores , Análisis EspacialRESUMEN
Background: Scrub typhus is an important public health issue in Korea. Risk factors for scrub typhus include both individual-level factors and environmental drivers, and some are related to the increased density of vector mites and rodents, the natural hosts of the mites. In this regard, deforestation is a potential risk factor, because the deforestation-induced secondary growth of scrub vegetation may increase the densities of mites and rodents. To examine this hypothesis, this study investigated the association between scrub typhus and deforestation. Methods: We acquired district-level data for 2006-2017, including the number of cases of scrub typhus reported annually, deforestation level, and other covariates. Deforestation was assessed using preprocessed remote-sensing satellite data. Bayesian regression models, including Poisson, negative binomial, zero-inflated Poisson, and zero-inflated negative binomial models, were examined, and spatial autocorrelation was considered in hierarchical models. A sensitivity analysis was conducted using different accumulation periods for the deforestation level to examine the robustness of the association. Results: The final models showed a significant association between deforestation and the incidence of scrub typhus (relative risk = 1.20, 95% credible interval = 1.15-1.24). The sensitivity analysis gave consistent results, and a potential long-term effect of deforestation for up to 5 years was shown. Conclusion: The results support the potential public health benefits of forest conservation by suppressing the risk of scrub typhus, implying the need for strong engagement of public health sectors in conservation issues from a One Health perspective.