RESUMEN

Since its introduction nearly a half century ago, the Eriksen flanker task has prompted multiple theoretical and methodological advancements in the study of attention and control. Early research with the task inspired the continuous flow model of information processing, which in turn prompted researchers to investigate the dynamics of response competition using continuous behavioral measures. In recent years, the use of such measures in psychological research has increased dramatically as hand-tracking techniques have become more widely accessible. The current article highlights commonly overlooked links between Eriksen and colleagues' pioneering research investigating the continuous flow model and recent hand-tracking research investigating the dynamics of attention and control. After providing an overview of two hand-tracking techniques frequently used in psychological research, we review a series of recent studies that have used these techniques to investigate how the processes underlying attention and control (a) unfold over the course of a response (within-trial dynamics), (b) are impacted by recent experience (cross-trial dynamics), and (c) contribute to age-related changes observed across the life span (developmental dynamics). In addition to highlighting the central role that the flanker task has played in advancing psychological research and theory, this review underscores the advantages of collecting continuous behavioral measures, both in Eriksen's seminal work and in contemporary hand-tracking studies.

Asunto(s)

Atención , Movimiento , Cognición , Mano , Humanos

RESUMEN

Systematic instruction on multi-step tasks (e.g., cooking, vocational skills, personal hygiene) is common for individuals with an intellectual disability. Unfortunately, when individuals with disabilities turn 22-years-old, they no longer receive services in the public school system in most states and systematic instruction often ends (Bouck, 2012). Rather than focusing instructional time on teacher-delivered training on the acquisition of specific multi-step tasks, teaching individuals with disabilities a pivotal skill, such as using self-instructional strategies, may be a more meaningful use of time. By learning self-instruction strategies that focus on generalization, individuals with disabilities can continue acquiring novel multi-step tasks in post-secondary settings and remediate skills that are lost over time. This review synthesizes the past 30 years of research related to generalized self-instruction to learn multi-step tasks, provides information about the types of self-instructional materials used, the ways in which participants received training to use them, and concludes with implications for practitioners and recommendations for future research.

Asunto(s)

Generalización Psicológica , Discapacidad Intelectual/rehabilitación , Aprendizaje , Instrucciones Programadas como Asunto , Autocuidado/métodos , Humanos

RESUMEN

Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether parasites can directly induce T reg cells. Foxp3 expression was stimulated in naive Foxp3⁻ T cells in mice infected with the intestinal helminth Heligmosomoides polygyrus. In vitro, parasite-secreted proteins (termed H. polygyrus excretory-secretory antigen [HES]) induced de novo Foxp3 expression in fluorescence-sorted Foxp3⁻ splenocytes from Foxp3-green fluorescent protein reporter mice. HES-induced T reg cells suppressed both in vitro effector cell proliferation and in vivo allergic airway inflammation. HES ligated the transforming growth factor (TGF) ß receptor and promoted Smad2/3 phosphorylation. Foxp3 induction by HES was lost in dominant-negative TGF-ßRII cells and was abolished by the TGF-ß signaling inhibitor SB431542. This inhibitor also reduced worm burdens in H. polygyrus-infected mice. HES induced IL-17 in the presence of IL-6 but did not promote Th1 or Th2 development under any conditions. Importantly, antibody to mammalian TGF-ß did not recognize HES, whereas antisera that inhibited HES did not affect TGF-ß. Foxp3 was also induced by secreted products of Teladorsagia circumcincta, a related nematode which is widespread in ruminant animals. We have therefore identified a novel pathway through which helminth parasites may stimulate T reg cells, which is likely to be a key part of the parasite's immunological relationship with the host.

Asunto(s)

Antígenos Helmínticos/inmunología , Factores de Transcripción Forkhead/inmunología , Regulación de la Expresión Génica/inmunología , Nematospiroides dubius/inmunología , Transducción de Señal/inmunología , Infecciones por Strongylida/inmunología , Linfocitos T Reguladores/inmunología , Factor de Crecimiento Transformador beta/inmunología , Animales , Antígenos Helmínticos/metabolismo , Benzamidas/farmacología , Proliferación Celular/efectos de los fármacos , Enfermedad Crónica , Dioxoles/farmacología , Factores de Transcripción Forkhead/biosíntesis , Factores de Transcripción Forkhead/genética , Regulación de la Expresión Génica/efectos de los fármacos , Regulación de la Expresión Génica/genética , Interacciones Huésped-Parásitos/efectos de los fármacos , Interacciones Huésped-Parásitos/genética , Interacciones Huésped-Parásitos/inmunología , Ratones , Ratones Endogámicos BALB C , Ratones Transgénicos , Nematospiroides dubius/metabolismo , Fosforilación/genética , Fosforilación/inmunología , Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores , Proteínas Serina-Treonina Quinasas/genética , Proteínas Serina-Treonina Quinasas/inmunología , Proteínas Serina-Treonina Quinasas/metabolismo , Receptor Tipo II de Factor de Crecimiento Transformador beta , Receptores de Factores de Crecimiento Transformadores beta/antagonistas & inhibidores , Receptores de Factores de Crecimiento Transformadores beta/genética , Receptores de Factores de Crecimiento Transformadores beta/inmunología , Receptores de Factores de Crecimiento Transformadores beta/metabolismo , Transducción de Señal/efectos de los fármacos , Transducción de Señal/genética , Proteína Smad2/genética , Proteína Smad2/inmunología , Proteína Smad2/metabolismo , Proteína smad3/genética , Proteína smad3/inmunología , Proteína smad3/metabolismo , Infecciones por Strongylida/genética , Infecciones por Strongylida/metabolismo , Linfocitos T Reguladores/metabolismo , Células TH1/inmunología , Células TH1/metabolismo , Células Th2/inmunología , Células Th2/metabolismo , Factor de Crecimiento Transformador beta/genética , Factor de Crecimiento Transformador beta/metabolismo

RESUMEN

Occupational therapy has been gradually slipping away from its foundation in mental health practice. In order to provide the best services to individuals with mental health disorders, the occupational therapy profession must maintain and expand its involvement in this area of practice. The purpose of this paper is to explore the threats and opportunities to promote education and practice in mental health from a student perspective. The authors reviewed the literature, distributed questionnaires, and conducted focus groups with occupational therapy students at a southeastern university. Based on findings in the literature and of the focus groups with students, the authors have drawn a list of suggestions to improve the visibility of occupational therapy in mental health care. These suggestions are for occupational therapy educational programs, mental health practitioners, AOTA, and state associations.