RESUMEN
Inhalation exposure of outbred female white rats (initial age about 4 months) to formaldehyde vapours (12.8 ± 0.69 mg/m(3)) 4h per day, 5 days per week during 10 weeks induced statistically significant changes in some indices characterizing differential WBC count, functional status of the central nervous system and liver, redox and porphyrin metabolisms, bone marrow micronuclei count as well as free amino acid spectrum of the blood serum. The development of intoxication was accompanied by increased urinary excretion of formaldehyde, formic acid and methanol. Daily oral administration of glutamate (150-180 mg), glycine (12 mg) and methionine (50mg) in combination rendered all of the formaldehyde's toxic effects reduced. This administration also caused a significant increase in the ratio between the rates of excretion of formic acid and non-metabolized formaldehyde. This shift supposedly reflects activation of oxidative detoxifying biotransformation of formaldehyde. Taking into consideration that the combination of amino acids used in this study proved innocuous in protectively effective doses, the administration in this combination may be recommended to humans exposed to high levels of formaldehyde in workplace or ambient air.
Asunto(s)
Formaldehído/toxicidad , Ácido Glutámico/farmacología , Glicina/farmacología , Metionina/farmacología , Administración por Inhalación , Administración Oral , Animales , Interacciones Farmacológicas , Femenino , Formaldehído/administración & dosificación , Intoxicación/tratamiento farmacológico , Intoxicación/etiología , RatasRESUMEN
The paper provides measurements of asbestos fiber levels in water sources from the area of the Bazhenovskoye chrysotile asbestos deposit. All study water samples contained asbestos fibers at concentrations one to three orders below the values standardized in the USA (7 x 10(6) fibers/liter). All the identified fibers belonged to chrysotile asbestos and no amphibole asbestos, such as tremolite asbestos, has been identified. The anthropogenic load of asbestos fibers in Asbest City's environment is increasing in the volume of 5.770 x 10(14) fibers/liter or 10.2 kg of chrysotile asbestos. The authors consider it advisable to continue studies to measure asbestos levels in the water sources in the areas located in the vicinity of other Russian asbestos deposits.