RESUMEN
The article presents new approach to treatment of radiation disorders presenting as indolent ulcers. The approach is based on autologous multipotent mesenchimal stromal cells applied locally and injected around the injuried zone. The ulcers heal due to the fact that the transplanted cells stimulate local regeneration processes, angiogenesis, ceased inflammation and apoptosis. The method is a new medical technology based on vast preclinical studies and could be put into medical practice.
Asunto(s)
Rayos gamma/efectos adversos , Trasplante de Células Madre Mesenquimatosas/métodos , Células Madre Multipotentes/trasplante , Radiodermatitis , Úlcera Cutánea/terapia , Anciano , Resistencia a Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neovascularización Fisiológica , Dosis de Radiación , Radiodermatitis/fisiopatología , Radiodermatitis/terapia , Regeneración , Índice de Severidad de la Enfermedad , Piel/efectos de la radiación , Úlcera Cutánea/etiología , Úlcera Cutánea/fisiopatología , Terapias en Investigación/métodos , Trasplante Autólogo/métodos , Resultado del TratamientoRESUMEN
Transplantation of mesenchymal stem cells, both at early and later stage after local exposure of rats source beta radiation dose, 90Sr/90Y 140 GR, stimulates recovery of damaged skin. Diminution area local radiation injuries and accelerate healing radiation ulcers. Clinically shows the high efficiency of the transplantations autologous mesenchymal stem cells in treatment of deep beam ulcers, intractable standard conservative treatment. Found promising application of mesenchymal stem cells for treatment of severe local radiation injuries and the need to develop the best possible conditions for their use.