RESUMEN

Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.

Asunto(s)

Anticuerpos Antivirales/análisis , Subtipo H1N1 del Virus de la Influenza A , Virus de la Influenza A/inmunología , Vacunas contra la Influenza/inmunología , Vacunación , Especificidad de Anticuerpos , Niño , Pruebas de Inhibición de Hemaglutinación , Humanos , Inmunoglobulina A/inmunología , Inmunoglobulina G/inmunología , Virus de la Influenza A/genética , Vacunas contra la Influenza/administración & dosificación , Recombinación Genética