RESUMEN

Through a combination of chemical and molecular analysis, a new polyene macrolactam named micromonolactam was obtained from two marine-derived Micromonospora species. This new polyene metabolite is a constitutional isomer of salinilactam A but contains a different polyene pattern and one cis double bond, in contrast to the all trans structure reported for salinilactam A. The molecular analysis data also established that micromonolactam is a hybrid polyketide derived from 11 polyketide units and a modified glutamate starter unit.

Asunto(s)

Vías Biosintéticas/genética , Lactamas Macrocíclicas/análisis , Micromonospora/química , Micromonospora/metabolismo , Polienos/análisis , Organismos Acuáticos/química , Organismos Acuáticos/metabolismo , ADN Bacteriano/química , ADN Bacteriano/genética , Ácido Glutámico/metabolismo , Lactamas Macrocíclicas/química , Micromonospora/genética , Datos de Secuencia Molecular , Estructura Molecular , Polienos/química , Análisis de Secuencia de ADN