RESUMEN

Two new meroterpenoid pyrones, chevalone G (1) and aszonapyrone C (2), a new indole alkaloid, 7-chlorofischerindoline (3) and a new bicyclic brasiliamide, brasiliamide H (4), together with sixteen known compounds, 5-20 were isolated from the fungus Neosartorya hiratsukae. Their structures were established on the basis of spectroscopic evidence. The antibacterial activity and the cytotoxic activity of new compounds were evaluated.

Asunto(s)

Antibacterianos/farmacología , Antineoplásicos/farmacología , Neosartorya/química , Pironas/química , Pironas/farmacología , Animales , Antibacterianos/química , Antineoplásicos/química , Bacterias/efectos de los fármacos , Línea Celular , Supervivencia Celular , Humanos , Modelos Moleculares , Estructura Molecular