RESUMEN

A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.

Asunto(s)

Fosfatos de Dinucleósidos/metabolismo , Agonistas del Receptor Purinérgico P2 , Nucleótidos de Uracilo/metabolismo , Calcio/metabolismo , Fosfatos de Dinucleósidos/síntesis química , Humanos , Unión Proteica , Receptores Purinérgicos P2/metabolismo , Espectrometría de Fluorescencia , Relación Estructura-Actividad , Transducción Genética , Células Tumorales Cultivadas , Nucleótidos de Uracilo/síntesis química