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Cuniculus paca, commonly known as the paca, is a rodent of the Cuniculidae family that is widely distributed throughout the Americas, including all Brazilian territories, and is abundant in the Amazon region. It is one of the most hunted species and faces significant predation in the extreme western Amazon region of Brazil because it constitutes a staple in the diet of local communities, for subsistence and commercial purposes. Understanding the helminthic fauna of these animals is of paramount importance, given that some nematodes have zoonotic potential and may pose risks to consumer health. This study aimed to contribute to the records of the nemtodes of this highly consumed species in the Amazon region, highlighting the occurrence of gastrointestinal parasites in free-living pacas intended for human subsistence consumption. The study was conducted in the Paranã da Floresta community, located in the municipality of Guajará, Amazonas from 2022 to 2023. The community members hunted this rodent for consumption and voluntarily provided the viscera for analysis. Nematodes were extracted from each organ. The organs were opened, and the contents were processed using a sieve (0.15 mm) and subsequently evaluated separately. In total, 10,157 nematodes were found in the 14 pacas. Based on morphological analyses, the nematodes were identified as Heligmostrongylus sedecimradiatus (n = 10,068), Trichuris sp. (n = 85), and Physaloptera sp. (n = 4). This study provides insights into the nematodes diversity of free-living pacas in the extreme Western Amazon region, emphasizing the importance of sanitary surveillance and public awareness of the risks associated with bushmeat consumption.

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This study investigates the short and long-term effects of IFNT and PAG on the transcriptome of endometrium and blood leukocytes. Holstein heifers received intrauterine infusions of one of the following treatments: 20 mL of a 200 µg/mL bovine serum albumin solution (BSA; vehicle) from day 14 to 16 of the estrous cycle (BSA), vehicle + 10 µg/mL of IFNT from day 14 to 16 (IFNT3), vehicle + 10 µg/mL of IFNT from day 14 to 19 (IFNT6), and vehicle + 10 µg/mL of IFNT from day 14 to 16 followed by vehicle + 10 µg/mL of IFNT + 5 µg/mL of PAG from day 17 to 19 (IFNT+PAG). RNA-seq analysis was performed in endometrial biopsies and blood leukocytes collected after treatments. Acute IFNT signaling in the endometrium (IFNT3 vs BSA), induced differentially expressed genes (DEG) associated with interferon activation, immune response, inflammation, cell death, and inhibited vesicle transport and extracellular matrix remodeling. Prolonged IFNT signaling (IFNT6 vs IFNT3) altered gene expression related to cell invasion, retinoic acid signaling, and embryo implantation. In contrast, PAG induced numerous DEG in blood leukocytes but only 4 DEG in the endometrium. In blood leukocytes, PAG stimulated genes involved in development and TGFB signaling while inhibiting interferon signaling and cell migration. Overall, IFNT is a primary regulator of endometrial gene expression, while PAG predominantly affected the transcriptome of circulating immune cells during early pregnancy. Further research is essential to fully grasp the roles of identified DEG in both the endometrium and blood leukocytes.

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The aim of this study was to develop and achieve consensus on a cariology teaching framework for dental schools in Latin American Spanish-speaking countries. The Delphi process, with a ≥8 0% pre-defined participants' agreement, included three phases and a Coordinating Group. During the Preparation phase three panels of experts were selected and invited to participate: a) Regional academic/professional Dental Associations (Associations-Panel): n = 12; b) Regional Dental Schools (Dental-Schools-Panel): existing dental schools (n = 263) from the 19 Spanish-speaking regional countries; c) International academic/professional associations Peer Experts (Peer-Panel): n = 4. Based on consensus documents from Europe, Colombia, the Caribbean, USA, Chile and Spain, and updated scientific evidence, the Coordinating Group developed a baseline framework proposal of domains, main competencies (MC) and specific competencies (SC). The Consultation-Agreement and Consensus phases included three rounds of questionnaires with a step-wise sharing of the MC updated version of the consensus framework with the Dental-Schools-Panel and including SC with the Associations-Panel. Diverse communication strategies were used ( e.g ., independent google-form questionnaires and workshops). Consensus was reached after an on-site Associations-Panel workshop and secret voting, followed by an online meeting with the Peers-Panel. A total of 127 academic/professional institutions participated (Associations-Panel: 11, 91.6%; Dental-Schools-Panel: 112, 42.6%, all countries; Peers-Panel: 4, 100%). The baseline Cariology teaching framework of 5 domains, 10 MC and 92 SC underwent modifications after agreements for a final consensus framework consisting of 5 domains, 10 MC and 85 SC. A Core Cariology curriculum framework in Spanish for Latin American Dental Schools was successfully developed and agreed upon with regional dental academic and professional institutions.

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RESUMO Objetivo: Identificar os diagnósticos de enfermagem de potenciais doadores de órgãos em morte encefálica segundo a Taxonomia NANDA-I. Método: Estudo observacional, transversal realizado em hospital público no interior do Ceará, Brasil. Coleta de dados nos meses de outubro e novembro de 2021, em 23 prontuários de potenciais doadores de órgãos. Dados foram analisados por estatística descritiva. Resultados: Identificaram-se 22 diferentes diagnósticos, em cinco dos 13 domínios da taxonomia da NANDA-I. Prevaleceram: risco de glicemia instável; risco de função hepática prejudicada; troca de gases prejudicada; mobilidade no leito prejudicada; padrão respiratório ineficaz; risco de infecção; risco de lesão por pressão; risco de aspiração; risco de débito cardíaco diminuído; risco de quedas, eliminação urinária prejudicada; risco de desequilíbrio eletrolítico e risco de pressão arterial instável. Conclusão: A identificação dos diagnósticos poderá favorecer o aprimoramento da prática e a aplicação do processo de enfermagem diante da assistência aos potenciais doadores de órgãos.

ABSTRACT Objective: To identify the nursing diagnoses of potential organ donors in brain death according to the NANDA-I Taxonomy. Method: Observational, cross-sectional study conducted in a public hospital in the interior of Ceará, Brazil. Data collection was realized in October and November 2021 in 23 medical records of potential organ donors. Descriptive statistics analyzed data. Results: Twenty-two diagnoses were identified in five of the 13 domains of the NANDA-I taxonomy. The following were prevalent: risk of unstable blood glucose; risk of impaired liver function; impaired gas exchange; impaired bed mobility; ineffective breathing pattern; risk of infection; risk of pressure injury; risk of aspiration; risk of decreased cardiac output; risk of falls, impaired urinary elimination; risk of electrolyte imbalance and risk of unstable blood pressure. Conclusion: The identification of diagnoses may favor the improvement of practice and the application of the nursing process in the care of potential organ donors.

RESUMEN Objetivo: Identificar los diagnósticos de enfermería de los posibles donantes de órganos en muerte encefálica según la Taxonomía NANDA-I. Método: Estudio observacional, transversal, realizado en un hospital público del interior de Ceará, Brasil. Recogida de datos en octubre y noviembre de 2021, en 23 historias clínicas de posibles donantes de órganos. Los datos se analizaron mediante estadísticas descriptivas. Resultados: Se identificaron 22 diagnósticos diferentes, en cinco de los 13 dominios de la taxonomía NANDA-I. Predominaron los siguientes: riesgo de glucemia inestable; riesgo de deterioro de la función hepática; deterioro del intercambio gaseoso; deterioro de la movilidad en la cama; patrón respiratorio ineficaz; riesgo de infección; riesgo de lesión por presión; riesgo de aspiración; riesgo de disminución del gasto cardíaco; riesgo de caídas, deterioro de la eliminación urinaria; riesgo de desequilibrio electrolítico y riesgo de tensión arterial inestable. Conclusión: La identificación de diagnósticos puede favorecer la mejora de la práctica y la aplicación del proceso de enfermería en el cuidado de los donantes potenciales de órganos.

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A destinação inadequada de resíduos sólidos, como os resíduos farmacêuticos, ainda é um problema a ser superado. Neste trabalho, objetivou-se estimar a prevalência de descarte inadequado de medicamentos no domicílio; analisar a frequência de como os medicamentos são descartados e descrever os motivos de descarte. Trata-se de um estudo transversal, descritivo, realizado por meio de entrevistas com os usuários da Atenção Básica do município de Araquari, Santa Catarina. Foram entrevistados 316 participantes, sendo (74,1%)do sexo feminino, com idade entre 28 e 47 anos (46,2%), ensino médio completo e incompleto (45,2%), e que possuem rede de esgoto em suas residências (39,2%). Dentre as formas farmacêuticas, os medicamentos sólidos foram apontados com a maior proporção de descarte inadequado (71,2%), sendo a maioria em lixo doméstico (53,2%). As tubulações domésticas foram indicadas como as vias mais frequentes de descarte para medicamentos líquidos (41,1%).Conclui-se que o hábito de guarda da sobra de medicamentos está associado ao descarte inadequado nas três formas farmacêuticas avaliadas. Além disso, a baixa escolaridade também se associou ao descarte inadequado de medicamentos líquidos e outras formas farmacêuticas.

The inadequate disposal of solid waste, such as pharmaceutical waste, is still a public health problemto be overcome. Inthis study, the objective was to estimate the prevalence of inappropriate disposal of medicines at home; analyze the frequency of how drugs are discarded and describe the reasons for discarding. This is a cross-sectional, descriptive study carried out through interviews with users of Primary Health Care in the city of Araquari, Santa Catarina. A total of 316 participants were interviewed, being (74.1%) female, aged between 28 and 47 years (46.2%), having complete and incomplete high school (45.2%), and who have a sewage system in their residences (39.2%). Among the pharmaceutical forms, solid drugs were identified with the highest proportion of inappropriate disposal (71.2%), most of them in domestic waste(53.2%). Domestic pipes were identified as the most frequent means of disposal for liquid medicines (41.1%). It is concluded that the habit of storing leftover medicines is associated with inappropriate disposal in the three pharmaceutical forms evaluated. In addition, low education was also associated with the inappropriate disposal of liquid medicines and other pharmaceutical forms.

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Abstract The aim of this study was to develop and achieve consensus on a cariology teaching framework for dental schools in Latin American Spanish-speaking countries. The Delphi process, with a ≥8 0% pre-defined participants' agreement, included three phases and a Coordinating Group. During the Preparation phase three panels of experts were selected and invited to participate: a) Regional academic/professional Dental Associations (Associations-Panel): n = 12; b) Regional Dental Schools (Dental-Schools-Panel): existing dental schools (n = 263) from the 19 Spanish-speaking regional countries; c) International academic/professional associations Peer Experts (Peer-Panel): n = 4. Based on consensus documents from Europe, Colombia, the Caribbean, USA, Chile and Spain, and updated scientific evidence, the Coordinating Group developed a baseline framework proposal of domains, main competencies (MC) and specific competencies (SC). The Consultation-Agreement and Consensus phases included three rounds of questionnaires with a step-wise sharing of the MC updated version of the consensus framework with the Dental-Schools-Panel and including SC with the Associations-Panel. Diverse communication strategies were used ( e.g ., independent google-form questionnaires and workshops). Consensus was reached after an on-site Associations-Panel workshop and secret voting, followed by an online meeting with the Peers-Panel. A total of 127 academic/professional institutions participated (Associations-Panel: 11, 91.6%; Dental-Schools-Panel: 112, 42.6%, all countries; Peers-Panel: 4, 100%). The baseline Cariology teaching framework of 5 domains, 10 MC and 92 SC underwent modifications after agreements for a final consensus framework consisting of 5 domains, 10 MC and 85 SC. A Core Cariology curriculum framework in Spanish for Latin American Dental Schools was successfully developed and agreed upon with regional dental academic and professional institutions.

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Objetivos: descrever a construção social do conceito social da tuberculose pulmonar que, na pesrpetiva de enfermeiros, emerge de conceitos alicerçados no estigma. Método: estudo descritivo, de abordagem qualitativa, com 12 enfermeiros de centros de diagnóstico pneumológico do Norte de Portugal. Dados colhidos nos meses de novembro de 2020 e janeiro de 2021 por entrevista semiestruturada, posteriormente analisados pela metodologia de análise de conteúdo. Resultados: dos discursos dos participantes emerge o conceito da tuberculose pulmonar. O entendimento da doença está envolto de mitos e tabus, com prognóstico sombrio, causa medo de contágio, de morte, pavor, vergonha, afastamento, isolamento social e negação da doença. Entre enfermeiros, falar de tuberculose é tema a evitar, é área que causa confusão e medo. Considerações finais: a conceção da palavra tuberculose persiste enraizada em conceitos e preconceitos. O estigma social permanece na sua essência e faz perpetuar o seu conceito negativo, até à atualidade.

Objetivos: describir la construcción social del concepto social de la tuberculosis pulmonar que, desde la perspectiva de enfermeros, emerge de conceptos basados en el estigma. Método: estudio descriptivo, de abordaje cualitativo, con 12 enfermeros de centros de diagnóstico pneumológico del Norte de Portugal. Datos recogidos en los meses de noviembre de 2020 y enero de 2021 por entrevista semiestructurada, posteriormente analizados por la metodología de análisis de contenido. Resultados: de los discursos de los participantes emerge el concepto de la tuberculosis pulmonar. El entendimiento de la enfermedad está envuelto de mitos y tabúes, con pronóstico sombrío, causa miedo de contagio, de muerte, pavor, vergüenza, alejamiento, aislamiento social y negación de la enfermedad. Entre enfermeras, hablar de tuberculosis es tema a evitar, es área que causa confusión y miedo. Consideraciones finales: la concepción de la palabra tuberculosis persiste enraizada en conceptos y prejuicios. El estigma social permanece en su esencia y hace perpetuar su concepto negativo, hasta la actualidad.

Objective: to describe the social construction of the social concept of pulmonary tuberculosis that, from the perspective of nurses, emerges from concepts based on stigma. Method: descriptive study, qualitative approach, with 12 nurses from centers of pneumological diagnosis in northern Portugal. Data collected in November 2020 and January 2021 by semi-structured interview, subsequently analyzed by content analysis methodology. Results: from the participants' discourses, the concept of pulmonary tuberculosis emerges. The understanding of the disease is surrounded by myths and taboos, with a bleak prognosis, causes fear of contagion, death, fear, shame, estrangement, social isolation and denial of the disease. Among nurses, talking about tuberculosis is a topic to avoid, it is an area that causes confusion and fear. Final considerations: the concept of the word tuberculosis persists rooted in concepts and prejudices. Social stigma remains at its core and perpetuates its negative concept to the present day.

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BACKGROUND: Hodgkin lymphoma (HL) is a rare lymphoproliferative disorder that occurs in about 10% of all cancer cases. Human immunodeficiency virus (HIV) is associated with an increased occurrence of a wide range of cancers, including HL due to progressive immunosuppression and co-infection with oncogenic viruses. However, the aim of this systematic review is to obtain evidence about the impact of the HIV infection in HL individuals. METHODS: We will obtain studies through PubMed, Embase, CINAHL, LILACS, CENTRAL, Web of Science, Scopus, Cochrane Library, and Google Scholar databases. The inclusion criteria will be observational studies (sectional, cohort, and case-control) that describe the impact of the HIV infection in HL individuals. Outcomes of interest include mortality, prevalence, causes of hospitalization, time between HIV diagnosis and HL diagnosis in days, comorbidities (systemic hypertension, diabetes mellitus, metabolic syndrome, others), T CD4 + cells/mm3 at HIV diagnosis and at HL diagnosis, viral load (log10 copies/mL) at HL diagnosis, and history of treatment abandon. Two reviewers, independently, will extract the data from each included study. Meta-analysis will then be carried out using fixed-effects or random-effects model, using the mean difference for continuous outcomes and the relative risk for dichotomous outcomes. Risk of bias will be assessed using the Newcastle-Ottawa Scale. The quality of evidence for each outcome will be assessed using Grading of Recommendations Assessment, Development and Evaluation methodology. Review Manager V.5.3.5 will be used for synthesis and subgroup analysis. To assess heterogeneity, we will compute the I2 statistics. Additionally, a quantitative synthesis will be performed if the included studies are sufficiently homogenous. ETHICS AND DISSEMINATION: This study will be a review of the published data, and thus it is not necessary to obtain ethical approval. The findings of this systematic review will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42021289520.

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Objective: To adapt and validate the Tuberculosis Related Stigma Scale (TRSS) in European Portuguese. Materials and method: A methodological study in a sample of 204 individuals being treated for pulmonary tuberculosis in Portuguese Pulmonary Diagnostic Centers, with at least one month of treatment or in follow-up. The evaluation process of linguistic and conceptual equivalence involved translation, the consensus among judges, back-translation, semantic validation, and pre-testing of the TRSS. The scale's psychometric properties were assessed by verifying the reliability and validity of the results and calculating Cronbach's alpha coefficient and the exploratory factor analysis of principal components, with Varimax rotation of the scale items. Results: The Portuguese version of the TRSS has a Cronbach's alpha coefficient of 0.94 and has 23 items distributed in two dimensions: "Community's perspectives on tuberculosis" (11 items) and "Person's perspectives on tuberculosis" (12 items). Its psychometric characteristics ensure adequate reliability and validity for the Portuguese population. Conclusions: The TRSS is a valid and reliable instrument to assess stigma in people with pulmonary tuberculosis and, to date, the only scale validated in this domain for the Portuguese population, which allows nurses to make an integrated intervention.

Objetivo: adaptar e validar a Tuberculosis Related Stigma Scale (TRSS) para o português de Portugal. Materiais e método: estudo metodológico, numa amostra de 204 pessoas em tratamento de tuberculose pulmonar, em Centros de Diagnóstico Pneumológico portugueses, com pelo menos um mês de tratamento, ou em follow-up. O processo de avaliação da equivalência linguística e conceptual envolveu tradução, consenso entre juízes, retrotradução, validação semântica e pré-teste da TRSS. As propriedades psicométricas da escala foram avaliadas através da verificação da confiabilidade e validade dos resultados, recorrendo ao cálculo do coeficiente alfa de Cronbach e da análise fatorial exploratória de componentes principais, com rotação Varimax dos itens da escala. Resultados: a versão portuguesa da TRSS tem um coeficiente alfa de Cronbach de 0,94 e ficou com 23 itens distribuídos por duas dimensões: "Perspetivas da comunidade em relação à tuberculose" (11 itens) e "Perspetivas da pessoa em relação à tuberculose" (12 itens). As características psicométricas garantem-lhe confiabilidade e validade adequadas para a população portuguesa. Conclusões: a TRSS constitui um instrumento válido e confiável para avaliar o estigma na pessoa com tuberculose pulmonar sendo, até ao momento, a única escala validada nesse domínio para a população portuguesa, o que permite ao enfermeiro uma intervenção integrada.

Objetivo: adaptar y validar la Tuberculosis Related Stigma Scale (TRSS) en el portugués de Portugal. Materiales y método: estudio metodológico, en una muestra de 204 personas en tratamiento de tuberculosis pulmonar, en Centros de Diagnóstico Neumológico portugueses, con por lo menos un mes de tratamiento o en seguimiento. El proceso de evaluación de la equivalencia lingüística y conceptual implicó traducción, consenso entre expertos, retrotraducción, validación semántica y preprueba de la TRSS. Las propiedades psicométricas de la escala se evaluaron a partir de la verificación de la fiabilidad y validez de los resultados, mediante el cálculo del coeficiente alfa de Cronbach y el análisis factorial exploratorio de componentes principales, con rotación Varimax de los ítems de la escala. Resultados: la versión portuguesa de la TRSS tiene un coeficiente alfa de Cronbach de 0,94 y quedó con 23 ítems distribuidos en dos dimensiones: "Perspectivas de la comunidad en relación con la tuberculosis" (11 ítems) y "Perspectivas de la persona en relación con la tuberculosis" (12 ítems). Las características psicométricas le garantizan confiabilidad y validez adecuadas para la población portuguesa. Conclusiones: la TRSS constituye un instrumento válido y fiable para medir el estigma en la persona con tuberculosis pulmonar y es, hasta ahora, la única escala validada en este dominio para la población portuguesa, lo que le permite al profesional de enfermería una intervención integrada.

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RESUMO Objetivo: avaliar as propriedades psicométricas da Escala de Satisfação com o Suporte Social em pessoas com tuberculose pulmonar. Método: estudo metodológico desenvolvido em duas etapas: validação de conteúdo dos itens; e avaliação das propriedades psicométricas da Escala. A colheita dos dados decorreu entre o período de outubro de 2020 e janeiro de 2021 numa amostra de 204 pessoas com tuberculose pulmonar, em Centros de Diagnóstico Pneumológico no Norte de Portugal. Resultados: a Escala validada apresenta um coeficiente α-Cronbach de 0,91, mantendo os 15 itens. Verificou-se uma distribuição diferente dos itens dentro das subescalas, designada como: "Satisfação com a família" (α-Cronbach=0,94) passa a integrar sete itens; "Satisfação com os amigos" (α-Cronbach=0,85) integra somente quatro itens; "Atividades Sociais" (α-Cronbach=0,86) e "Intimidade" (α-Cronbach=0,77) passam de três e quatro itens da escala original, para dois itens cada uma. Conclusão: a versão da Escala de Satisfação com o Suporte Social pode constituir-se em um recurso para o planejamento dos cuidados de Enfermagem à pessoa com tuberculose pulmonar.

ABSTRACT Objective: to evaluate the psychometric properties of the Satisfaction with Social Support Scale in people with pulmonary tuberculosis. Method: methodological study developed in two stages: content validation of the items; and assessment of the psychometric properties of the Scale. Data were collected between October 2020 and January 2021 in a sample of 204 individuals with pulmonary tuberculosis in Pulmonary Diagnostic Centers in Northern Portugal. Results: The validated scale has α-Cronbach's coefficient of 0.91, keeping the 15 items. There was a different distribution of items within the subscales, designated as: "Satisfaction with family" (α-Cronbach=0.94) now includes seven items; "Satisfaction with friends" α-Cronbach =0.85) includes only four items; "Social activities" (α-Cronbach=0.86) and "Intimacy" (α-Cronbach =0.77) go from three and four items of the original scale to two items each. Conclusion: the version of the Satisfaction with Social Support Scale can be a resource for planning nursing care for people with pulmonary tuberculosis.

RESUMEN Objetivo: evaluar las propiedades psicométricas de la Escala de Satisfacción con el Apoyo Social en personas con tuberculosis pulmonar. Método: estudio metodológico desarrollado en dos etapas: validación del contenido de los ítems; y evaluación de las propiedades psicométricas de la Escala. Los datos se recogieron entre octubre de 2020 y enero de 2021 en una muestra de 204 individuos con tuberculosis pulmonar en centros de diagnóstico pulmonar del norte de Portugal. Resultados: La escala validada tiene un coeficiente de α-Cronbach de 0,91, manteniendo los 15 ítems. Se encontró una distribución diferente de los ítems dentro de las subescalas, a saber: "Satisfacción con la familia" (α--Cronbach=0,94) incluye ahora siete ítems; "Satisfacción con los amigos" (α--Cronbach=0,85) incluye sólo cuatro ítems; "Actividades sociales" (α-Cronbach=0,86) e "Intimidad" (α--Cronbach=0,77) pasan de tres y cuatro ítems de la escala original a dos ítems cada uno. Conclusión: la versión de la Escala de Satisfacción con el Apoyo Social puede constituirse en un recurso para la planificación de los cuidados de Enfermería a personas con tuberculosis pulmonar.

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Introducción: El trauma craneoencefálico (LCT) es cualquier impacto que afecta la región de la cabeza que involucra el cuero cabelludo, el cráneo, el cerebro y los vasos sanguíneos, afectando estas estructuras. Los profesionales de enfermería desempeñan un papel fundamental al ayudar a estos pacientes. Objetivo: Enumerar los diagnósticos de enfermería (DE) de NANDA I que se pueden proponer para pacientes hospitalizados con LCT. Método: Revisión integral de la literatura, realizada en las bases de datos: LILACS, BDENF, IBECS, MEDLINE, CINAHL, SCOPUS y WEB OF SCIENCE, utilizando los términos de búsqueda: “Traumatismo craneocerebral / craneocerebral”, “Diagnóstico de enfermería / Diagnóstico de enfermería " y " Enfermagem / Enfermería ". Se incluyeron artículos en portugués, inglés y español. Resultados: Se seleccionaron 12 artículos. A partir de la lectura de los estudios, en función de las características clínicas y las necesidades básicas afectadas de los pacientes con LCT, 18 ED se enumeran, organizan en orden alfabético y de acuerdo con el dominio en el que se encuentran en NANDA YO. Consideraciones finales: Los resultados de esta investigación permitieron caracterizar aspectos importantes relacionados con el paciente con LCT y llevar el enfoque de la literatura sobre diagnósticos de enfermería a esta audiencia. Hay una brecha en las investigaciones que abordan las DE para pacientes con LCT, teniendo en cuenta que una parte importante de la investigación informa sobre las manifestaciones clínicas percibidas durante la atención de enfermería y no aporta los diagnósticos elaborados. (AU)

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Soil-transmitted helminths (STHs) are parasites transmitted through contact with soil contaminated with their infective eggs/larvae. People are infected by exposure to human-specific species or animal species (zoonotic agents). Fecal samples containing eggs of Ascaris suum or Lemurostrongylus sp. were sprayed with spores of the soil saprophytic filamentous fungi Clonostachys rosea (CR) and Trichoderma atrobrunneum (TA). The antagonistic effect was assessed by estimating the viability of eggs and their developmental rate. Compared to the controls (unexposed to fungi), the viability of the eggs of A. suum was halved in CR and decreased by two thirds in TA, while the viability of the eggs of Lemurostrongylus sp. was reduced by one quarter and one third in CR and TA treatments, respectively. The Soil Contamination Index (SCI), defined as the viable eggs that attained the infective stage, reached the highest percentages for A. suum in the controls after four weeks (66%), with 21% in CL and 11% in TA. For Lemurostrongylus sp., the values were 80%, 49%, and 41% for control, CR and TA treatments, respectively. We concluded that spreading spores of C. rosea or T. atrobrunneum directly onto the feces of animal species represents a sustainable approach under a One Health context to potentially reduce the risk of zoonotic STHs in humans.

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Objetivo: elencar com base nas manifestações clínicas da doença, os principais diagnósticos de enfermagem que podem ser aplicados para crianças, adultos, gestantes e idosos com COVID-19. Método: revisão integrativa da literatura nacional e internacional, realizada no período de março a maio de 2020, a partir do cruzamento entre os termos: "pacientes", "infecções por coronavírus" e "sinais e sintomas", usando o operador booleano and. Selecionou-se 26 estudos, apresentando em quadro. Utilizouse a taxonomia da Associação Norte-Americana de Diagnósticos de Enfermagem e a Classificação Internacional para a Prática de Enfermagem para elencar os diagnósticos pertinentes ao quadro clínico frequentemente presente entre participantes com covid19. Resultados: conforme os sinais e sintomas presentes na fase aguda da doença em pacientes sob internação e em uso de terapia medicamentosa, os diagnósticos predominantes foram proteção ineficaz relacionado à incapacidade de proteção contra agente infeccioso evidenciado por tosse, calafrios e fadiga, presença de tosse, Hipertermia relacionada a processo infeccioso evidenciado por pele quente ao toque, padrão respiratório ineficaz relacionado à dor e fadiga evidenciado por dispneia. Considerações finais: alguns diagnósticos são prevalentes, entretanto, a avaliação deve ser individual, bem como a assistência, baseada nas necessidades de cada indivíduo.(AU)

Objective: to list, based on the clinical manifestations of the disease, the main nursing diagnoses that can be applied to children, adults, pregnant women and the elderly with COVID-19. Method: integrative review of national and international literature, carried out from March to May 2020, based on the crossing between the terms: "patients", "coronavirus infections" and "signs and symptoms" , using the Boolean operator and. 26 studies were selected and presented in a table. The taxonomy of the North American Association of Nursing Diagnoses and the International Classification for Nursing Practice were used to list the diagnoses relevant to the clinical picture frequently present among participants with covid-19. Results: according to the signs and symptoms present in the acute phase of the disease in patients hospitalized and using drug therapy, the prevalent diagnoses were ineffective protection related to the inability to protect against an infectious agent evidenced by cough, chills and fatigue, presence of cough, related hyperthermia an infectious process evidenced by hot skin to the touch, ineffective breathing pattern related to pain and fatigue evidenced by dyspnea. Final considerations: some diagnoses are prevalent, however, the assessment must be individual, as well as assistance, based on the needs of each individual.(AU)

Objetivo: enumerar, con base en las manifestaciones clínicas de la enfermedad, los principales diagnósticos de enfermería que pueden aplicarse a niños, adultos, mujeres embarazadas y ancianos con COVID-19. Método: revisión integradora de la literatura nacional e internacional, realizada entre marzo y mayo de 2020, basada en el cruce entre los términos: "pacientes", "infecciones por coronavirus" y "signos y síntomas" , utilizando el operador booleano y. Se seleccionaron 26 estudios y se presentaron en una tabla. La taxonomía de la Asociación Norteamericana de Diagnósticos de Enfermería y la Clasificación Internacional para la Práctica de Enfermería se utilizaron para enumerar los diagnósticos relevantes para el cuadro clínico frecuentemente presente entre los participantes con covid-19. Resultados: de acuerdo con los signos y síntomas presentes en la fase aguda de la enfermedad en pacientes hospitalizados y que usan terapia farmacológica, los diagnósticos prevalentes fueron protección ineficaz relacionada con la incapacidad de protección contra un agente infeccioso evidenciado por tos, escalofríos y fatiga, presencia de tos, hipertermia relacionada un proceso infeccioso evidenciado por la piel caliente al tacto, un patrón de respiración ineficaz relacionado con el dolor y la fatiga evidenciada por la disnea. Consideraciones finales: algunos diagnósticos son frecuentes, sin embargo, la evaluación debe ser individual, así como asistencia, según las necesidades de cada individuo.(AU)

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The use of smart materials, especially the carbon-based nanomaterials, is increasing each day. Among the several carbon-based nanomaterials, graphene quantum dots are one of the most impressive ones, not only by its quantum behavior but due to the adsorption quality conferred by electrostatic interactions from the negatively charged groups as the huge surface area (2.630 m2/g). In this study, we developed and tested graphene quantum dots (GQDs) as smart nano-adsorbents of uranium (238U) from the radioactive industry waste. The GQDs were developed in a size range of 160-220 nm using a totally green route. The results showed that the GQDs were capable to adsorb almost 40% of the uranium (238U) in alamine 3366 solution. Also, the results demonstrated that using GQDs treatment-like smart nanomaterials for radioactive waste in a volume reduction of almost 90% is achieved, helping the storage process as the final disposal of this material. We may conclude that GQDs may represent a smart device for the treatment of radioactive waste as an alternative of absorbent in the radioactive industry.

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Resumo Este estudo avaliou o conhecimento de médicos de equipes da Estratégia Saúde da Família (ESF) sobre a Vigilância em Saúde e suas áreas, de modo a compreender como se dá a relação entre estes setores e identificar os pontos positivos e os nós críticos que prejudicam a integração entre eles. Foi realizado grupo focal com oito médicos de municípios do interior de Minas Gerais. O tempo médio de atuação dos profissionais na ESF foi de 5,7 ± 3,25 anos e o tempo médio de atuação no Sistema Único de Saúde foi de 6,8 ± 3,33 anos. Foram identificadas três categorias temáticas, quais sejam: "Compreensões sobre Vigilância em Saúde", "Vigilâncias Reconhecidas" e "Relações dos Profissionais da Atenção Básica com a Vigilância em Saúde". A Vigilância em Saúde foi percebida como responsável pelo controle e prevenção de doenças e norteadora do planejamento das ações de saúde. As vigilâncias mais reconhecidas foram a Epidemiológica e Sanitária. Os principais nós críticos identificados estão associados à falta de conhecimento mútuo e interação entre a Atenção Básica e a Vigilância em Saúde, que por conseguinte leva ao pouco envolvimento e integração dessas áreas no processo de notificação, acompanhamento e resolução de doenças e agravos de responsabilidade compartilhada.

Abstract This study evaluated the knowledge of the Family Health Strategy team physicians about Health Surveillance and related areas to verify the relation between these sectors, allowing to identify the positive points and critical nodes that undermine the integration between them. A focus group was conducted with eight physicians from municipalities in the countryside of Minas Gerais. The average working time of professionals in FHS was 5.7 ± 3.25 years and the average working time in SUS was 6.8 ± 3.33 years. Three thematic categories were identified, namely, "Understanding Health Surveillance", "Recognized Surveillance" and "Relation of Primary Care Professionals with Health Surveillance". Health Surveillance was perceived as responsible for disease control and prevention, as well as for guiding the planning of health actions. The most recognized types of vigilance was Epidemiological Surveillance and Sanitary Surveillance. The main critical nodes identified are associated with a lack of mutual knowledge and interaction between Primary Care and Health Surveillance, which consequently leads to the low involvement and integration of these areas in the process of notification, monitoring and resolution of diseases and grievances of shared responsibility.

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Objetivo: avaliar a satisfação e o bem-estar de puérperas na assistência ao parto e nascimento. Método: trata-se de um estudo quantitativo, descritivo e transversal, com 78 puérperas, ao ser utilizado um questionário para a caracterização sociodemográfica e obstétrica, analisado pela estatística descritiva e testes de associações, por meio do teste Qui-quadrado, adotando-se um nível de significância de 95%. Resultados: verificou-se a média de idade de 28,4 anos, destacando-se que 98,7% das pesquisadas realizaram pré-natal, 73,1% receberam alguma orientação profissional no hospital e 93,6% tiveram a presença de um acompanhante. Registra-se, sobre a escala, que 62,8% das mulheres apresentaram ótimo bem-estar. Informa-se que os domínios III e V foram os mais bem avaliados e o domínio IV, o pior. Negou-se a relevância estatística nas correlações entre os níveis de bem-estar e os dados do parto. Conclusão: avaliouse que as mulheres apresentaram ótimo bem-estar na parturição. Elencam-se o contato pele a pele e a presença de acompanhante como fatores importantes. Considera-se necessário incorporar a empatia e a gentileza na assistência para se reduzir os níveis de mal-estar.(AU)

Objective: to evaluate the satisfaction and well-being of puerperal women in childbirth and birth care. Method: this is a quantitative, descriptive and cross-sectional study, with 78 puerperal women, when using a questionnaire for sociodemographic and obstetric characterization, analyzed by descriptive statistics and association tests, using the Chisquare test, adopting significance level of 95%. Results: there was a mean age of 28.4 years, highlighting that 98.7% of those surveyed performed prenatal care, 73.1% received some professional guidance in the hospital and 93.6% had the presence of a companion. It is registered, on the scale, that 62.8% of women showed excellent well-being. It is reported that domains III and V were the best evaluated and domain IV, the worst. Statistical relevance in the correlations between well-being levels and delivery data was denied. Conclusion: it was evaluated that women had excellent well-being in parturition. Skin-to-skin contact and the presence of a companion are important factors. It is considered necessary to incorporate empathy and kindness in care to reduce levels of malaise.(AU)

Objetivo: evaluar la satisfacción y el bienestar de las mujeres puerperales en el cuidado del parto y nacimiento. Método: se trata de un estudio cuantitativo, descriptivo y transversal, con 78 mujeres puerperales, al utilizar un cuestionario para caracterización sociodemográfica y obstétrica, analizado mediante estadística descriptiva y pruebas de asociación, utilizando la prueba de Chi-cuadrado, adoptando nivel de significancia del 95%. Resultados: hubo una edad promedio de 28.4 años, destacando que el 98.7% de los encuestados realizó atención prenatal, el 73.1% recibió alguna orientación profesional en el hospital y el 93.6% tuvo la presencia de un compañero. Se registra, en la escala, que el 62.8% de las mujeres mostraron un excelente bienestar. Se informa que los dominios III y V fueron los mejor evaluados y el dominio IV, el peor. Se denegó la relevancia estadística en las correlaciones entre los niveles de bienestar y los datos del parto. Conclusión: se evaluó que las mujeres tenían un excelente bienestar en el parto. Se notó que el contacto piel con piel y la presencia de un compañero son factores importantes. Se considera necesario incorporar empatía y amabilidad en la atención para reducir los niveles de malestar.(AU)

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Objective: The study's goal has been to analyze if environmental or occupational exposure to pesticides can produce changes in pregnant women living in a countryside municipality. Methods: The participants of this study were twenty-three pregnant women, who both answered a questionnaire and donated biological material in order to perform Micronucleus (MN) Tests in lymphocytes, oral epithelial cells, and also for measuring the enzyme activity of erythrocyte acetylcholinesterase. Results: Considering the total analyzed samples, the following was found: an average of 8 ± 2.92 MN/1000 oral epithelial cells from urban participants; an average of 6.82 ± 3.43 MN/1000 oral epithelial cells from rural participants; and 100% of the microscope slides contained cells with two MN, which shows high intensity lesions to the DNA. There was found a high frequency of spontaneous abortions (34.8%), greater than in Brazil. Conclusion: The exposure of pregnant women living in a countryside municipality to pesticides may increase the rate of spontaneous abortions, as well as the chances of mutagenic effects

Objetivo: Analisar se a exposição ambiental ou ocupacional aos agrotóxicos causa alterações em gestantes residentes em um município rural. Métodos: Compuseram a amostra 23 gestantes, que responderam a um questionário e doaram amostras biológicas para a realização dos testes de micronúcleos (MN) em linfócitos, em células do epitélio oral, e para a dosagem da atividade da enzima acetilcolinesterase eritrocitária. Resultados: Obteve-se uma média de 8 ± 2,92 MN/1000 células do epitélio oral analisadas em amostras de participantes da zona urbana, 6,82 ± 3,43 MN/1000 de participantes da zona rural, e 100% das lâminas continham células com dois MN, o que demonstra lesões ao DNA de maior intensidade. Encontrou-se uma frequência elevada de casos de abortos espontâneos (34,8%), superior à encontrada no Brasil. Conclusão: A exposição de gestantes residentes em um município rural aos agrotóxicos eleva a taxa de abortos espontâneos, bem como as chances de ocorrência de efeitos mutagênicos

Objetivo: Analizar si la exposición ambiental o ocupacional a los agrotóxicos causa cambios en gestantes residentes en un municipio rural. Métodos: Compusieron la muestra 23 gestantes, que respondieron a un cuestionario y donaron muestras biológicas para la realización de las pruebas de micronúcleos (MN) en linfocitos, en células del epitelio oral, y para la dosificación de la actividad de la enzima acetilcolinesterasa eritrocitaria. Resultados: Se obtuvieron una media de 8 ± 2,92 MN / 1000 células del epitelio oral analizadas en muestras de participantes de la zona urbana, 6,82 ± 3,43 MN / 1000 de participantes de la zona rural, y el 100% de las láminas contenían células con dos MN, lo que demuestra lesiones al ADN de mayor intensidad. Se encontró una frecuencia elevada de casos de abortos espontáneos (34,8%), superior a la encontrada en Brasil. Conclusión: La exposición de gestantes residentes en un municipio rural a los agrotóxicos eleva la tasa de abortos espontáneos, así como las posibilidades de ocurrencia de efectos mutagênicos

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Background: The objective of this study was to analyze the gene expression profile of the proinflammatory interleukins, (IL-1ß and IL-18) in patients with premalignant lesions and cervical cancer. Methods: Total IL-1ß and IL-18 mRNA was quantified by qPCR to obtain the expression data in cervical tissues. A total of 74 cervical biopsies were obtained from women undergoing a colposcopy. The samples were divided into: normal (19), low level lesions (LSIL) or NIC I (17), high level lesions (HSIL) or CIN II and CIN III (29) and cancer (9). The normal cervical tissue samples were included as controls. The OR and 95% CI were calculated for the determination of the risk of progression between each type of lesion and cancer using logistic regression. Results: The results showed that an increase in the risk of progression of pre-neoplastic lesions to cancer was between 2.5 and 2.08 times higher in women with lower IL-1ß and IL-18 expression, respectively. Conclusions: This study provided evidence that IL-1ß and IL-18 are potential biomarkers that can be explored in further studies for monitoring the evolution of pre-neoplastic lesions and avoiding overtreatment or undertreatment of the patients.

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ABSTRACT Purpose: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment. Materials and Methods: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. Results: The time that elapsed from penile constrictor application to hospital admission varied from 10 hours to 6 weeks (mean: 22.8 hours). Non-metallic devices were used by 18 patients (66.6%) while the other nine (33.4%) had used metallic objects. Acute urinary retention was present in six (23%) patients, of whom four (66.6%) underwent percutaneous surgical cystotomy and two (33.4%) underwent simple bladder catheterization. The main reason for penile constrictor placement was erectile dysfunction, accounting for 15 (55.5%) cases. Autoerotic intention, psychiatric disorders, and sexual violence were responsible in five (18.5%), five (18.5%), and two (7.4%) cases, respectively. The mean hospital stay was 18 hours (range, 6 hours to 3 weeks). Conclusion: Penile strangulation treatment must be immediate through the extraction of the foreign body, avoiding vascular impairments that can lead to serious complications. Most patients present with low-grade injuries and use penile constrictors due to erectile dysfunction. Removal of constrictor device can be challenging. The use of specific tools for achieving penile release from constrictors is a fast, safe and effective method. Patients with urinary retention may require urinary diversion.

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PURPOSE: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment. MATERIALS AND METHODS: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. RESULTS: The time that elapsed from penile constrictor application to hospital admission varied from 10 hours to 6 weeks (mean: 22.8 hours). Non-metallic devices were used by 18 patients (66.6%) while the other nine (33.4%) had used metallic objects. Acute urinary retention was present in six (23%) patients, of whom four (66.6%) underwent percutaneous surgical cystotomy and two (33.4%) underwent simple bladder catheterization. The main reason for penile constrictor placement was erectile dysfunction, accounting for 15 (55.5%) cases. Autoerotic intention, psychiatric disorders, and sexual violence were responsible in five (18.5%), five (18.5%), and two (7.4%) cases, respectively. The mean hospital stay was 18 hours (range, 6 hours to 3 weeks). CONCLUSION: Penile strangulation treatment must be immediate through the extraction of the foreign body, avoiding vascular impairments that can lead to serious complications. Most patients present with low-grade injuries and use penile constrictors due to erectile dysfunction. Removal of constrictor device can be challenging. The use of specific tools for achieving penile release from constrictors is a fast, safe and effective method. Patients with urinary retention may require urinary diversion.

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