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BACKGROUND: The preclinical efficacy of mesenchymal stem cell (MSC) therapy after intravenous infusion has been promising, but clinical studies have yielded only modest results. Although most preclinical studies have focused solely on the ischemic lung, it is crucial to evaluate both lungs after ischemia-reperfusion injury, considering the various mechanisms involved. This study aimed to bridge this gap by assessing the acute effects of bone marrow MSC(BM) infusion before ischemic insult and evaluating both ischemic and non-ischemic lungs after reperfusion. METHODS: Eighteen male Wistar rats (403 ± 23 g) were anesthetized and mechanically ventilated using a protective strategy. After baseline data collection, the animals were randomized to 3 groups (n = 6/group): (1) SHAM; (2) ischemia-reperfusion (IR), and (3) intravenous MSC(BM) infusion followed by IR. Ischemia was induced by complete clamping of the left hilum, followed by 1 h of reperfusion after clamp removal. At the end of the experiment, the right and left lungs (non-ischemic and ischemic, respectively) were collected for immunohistochemistry and molecular biology analysis. RESULTS: MSC(BM)s reduced endothelial cell damage and apoptosis markers and improved markers associated with endothelial cell integrity in both lungs. In addition, gene expression of catalase and nuclear factor erythroid 2-related factor 2 increased after MSC(BM) therapy. In the ischemic lung, MSC(BM) therapy mitigated endothelial cell damage and apoptosis and increased gene expression associated with endothelial cell integrity. Conversely, in the non-ischemic lung, apoptosis gene expression increased in the IR group but not after MSC(BM) therapy. CONCLUSION: This study demonstrates distinct effects of MSC(BM) therapy on ischemic and non-ischemic lungs after ischemia-reperfusion injury. The findings underscore the importance of evaluating both lung types in ischemia-reperfusion studies, offering insights into the therapeutic potential of MSC(BM) therapy in the context of lung injury.

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Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms developed by this species. The present study evaluates the inhibition of the MepA efflux pump by thiadiazine-derived compounds. For this purpose, thiadiazine-derived compounds (IJ-14 to IJ-20) were tested against S. aureus K2068 strains. Microdilution tests were initially conducted to assess the Minimum Inhibitory Concentration (MIC) of the compounds and their efflux pump inhibition activity. In addition, fluorimetry tests were performed using BrEt emission and tests were conducted to inhibit the expression of the mepA gene. This involved comparing the bacterial gene expression with the antibiotic alone to the gene expression after combining compounds (IJ-17 and IJ-20) with the antibiotic. Furthermore, membrane permeability assessment tests and in silico molecular docking tests were performed. It was observed that the IJ17 and IJ20 compounds exhibited direct activity against the tested strain. The IJ17 compound produced significant results in the gene inhibition tests, which was also evidenced through the membrane permeability alteration test. These findings suggest that thiadiazine-derived compounds have promising effects against one of the main resistance mechanisms, with the IJ17 compound presenting observable mechanisms of action.

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The composition of the intestinal microbiota can influence the metabolism and overall functioning of avian organisms. Therefore, the objective of this study was to evaluate the effect of three different probiotics and an antibiotic on the microbiomes of 1.400 male Cobb® broiler raised for 42 days. The experiment was conducted with the following treatments: positive control diet (basal diet + antibiotic); negative control diet (basal diet without antibiotic and without probiotic); basal diet + Normal Avian Gut Flora (NAGF); basal diet + multiple colonizing strain probiotics (MCSPs); and basal diet + non-colonizing single strain probiotics (NCSSPs). The antibiotic (enramycin-antibiotic growth promoter) and probiotics were administered orally during all experiment (1 to 42 days), mixed with broiler feed. To determine the composition of the microbiota, five samples of ileal digesta were collected from 42-day-old chickens of each experimental group. The alpha and beta diversity of the ileal microbiota showed differences between the groups. MCSPs presented greater richness and uniformity compared to the positive control, negative control, and NCSSPs treatments, while the negative control exhibited greater homogeneity among samples than NCSSPs. MCSPs also showed a higher abundance of the genus Enterococcus. There were differences between the groups for low-abundance taxa (<0.5%), with NAGF showing higher levels of Delftia, Brevibacterium, and Bulleidia. In contrast, NCSSPs had a higher abundance of Ochrobactrum, Rhodoplanes, and Nitrospira. It was concluded that the treatments analyzed in this study induced modulations in the ileal microbiota of the chickens examined.

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Developing and investigating advanced multifunctional materials with magnetic properties as candidates for assembling spin qubits for quantum computing is imperative. A new polytopic ligand based on oxamate and aniline was used to promote the synthesis of three neutral homometallic lanthanide-coordinated polymers. New complexes with the formula {Ln(phox)3(DMSO)2(H2O)}n, where Ln = Eu3+ (1), Gd3+ (2), and Tb3+ (3) [phox = N-(phenyl)oxamate and DMSO = dimethylsulfoxide], were synthesized and well characterized by spectroscopic methods as well as X-ray crystallographic analysis. All crystalline structures comprise neutral zigzag chains. The lanthanide ions are linked by three phox ligands, in which two oxygen atoms from two different ligands are responsible for connecting the trivalent lanthanide ions, and one phox ligand completes the coordination sphere in a bis-bidentate mode, together with two DMSO molecules and one water coordination molecule. The coordination sphere of lanthanide ions consisted of spherical capped square antiprism (CSAPR-9) symmetry. The magnetic properties of 1-3 were investigated in the 2-300 K temperature range. The dynamic (ac) magnetic properties of 2 reveal a frequency dependence involving the phonon bottleneck mechanism below 33 K under nonzero applied dc magnetic fields, resulting in an example of a field-induced single-molecule magnet. Solid-state photophysical measurements for Eu3+ (1) and Tb3+ (3) complexes indicate that the N-(phenyl)oxamate ligands are very efficient in sensitizing the lanthanide(III) ions in the visible region of the electromagnetic spectrum. Compounds 1 and 3 exhibited an emission in the red and green regions, respectively. Experimental results and theoretical calculations using the Sparkle/RM1 method support a quantum efficiency of ∼72% for 1, suggesting its potential as a candidate for light conversion molecular devices (LCMDs).

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BACKGROUND: The beneficial properties of wine by-products include actions that help prevent and treat cardiovascular conditions such as hypertension, primarily due to their antioxidant effects. Novel pharmacotherapies are being developed to treat arterial hypertension, including investigations into natural products exhibiting biological activity, necessitating rigorous evaluation of their efficacy and safety. This study aimed to identify and quantify phenolic compounds in Syrah (Vitis vinifera) grapes grown in the Brazilian Cerrado and their presence in winemaking by-products. It also examined the effects of grape pomace on blood pressure. METHODS: Fresh grapes, pomace, and lees, were subjected to spectrophotometric determination of total phenolic compounds, followed by identification and quantification using HPLC-DAD-ESI-MSn. Normotensive male rats (Wistar) and spontaneously hypertensive rats (SHR) received grape pomace-enriched (150 or 300 mg/kg/day, 14 days) or standard chow. Indirect arterial pressure was assessed, while vascular reactivity was evaluated in mesenteric resistance arteries. RESULTS: Pomace samples exhibited higher total phenolic compound concentrations than grapes or lees. Seven derivatives of hydroxycinnamic acids and twenty-one flavonols were identified. Quercetin-3-glucoside and ethyl caffeate were the most abundant phenolic compounds. Grape pomace-enriched chow demonstrated a dose-dependent hypotensive effect in rats. CONCLUSION: the abundance of flavonols and hydroxycinnamic acids, combined with their hypotensive effects, underscores the therapeutic potential of fine wine-making by-products produced in the Brazilian Cerrado.

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Antihipertensivos , Presión Sanguínea , Hipertensión , Fenoles , Ratas Endogámicas SHR , Ratas Wistar , Vitis , Vino , Animales , Vitis/química , Masculino , Fenoles/análisis , Fenoles/farmacología , Presión Sanguínea/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Ratas , Vino/análisis , Antihipertensivos/farmacología , Antioxidantes/farmacología , Antioxidantes/análisis , Extractos Vegetales/farmacología , Frutas/química , Brasil

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The use of artificial lighting during the incubation phase is a tool that has been studied with the aim of increasing the production rates and hatchability. Using this, this study aims to investigate the effects of the luminous incidence of white and red monochromatic light on the production and metabolism of broiler chicks subjected to low temperatures. A total of 315 eggs of Ross 708 heavy breeders were used. The eggs were distributed randomly, with 35 eggs per tray, totaling 105 eggs per incubator. The treatments were the following: incubation without the use of light; the use of white monochromatic light; and the use of red monochromatic light. The lamps used were of the LED type. The samples were distributed in the factorial completely randomized experimental design with position effect on the tray. Candling, egg weighing, calculating the probability of survival and egg weight loss were performed. Temperatures were recorded using a thermographic camera. At birth, three chicks per tray were euthanized for evaluation: weight with and without yolk residue, gastrointestinal tract biometry, and blood and liver biochemistry. Analyses were performed using the R computational program. It was observed that there was a significant effect of the treatments on the levels of calcium, phosphorus, cholesterol, amylase, glucose, urea and glutamate pyruvate transaminase on the biochemical profile of the blood and on the thermographic temperatures of the eggs; the experiment was kept at low temperatures resulting in thermal stress, with an average temperature of 34.5 °C. Therefore, the use of red and white monochromatic light in the artificial incubation process for brown-colored eggs is not recommended, because in the post-hatching phase, it promoted the metabolism dysregulation on the blood biochemical profile to control the differentiation in the wavelength of traditional incubation.

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INTRODUCTION: Catheter-related thrombosis (CRT) accounts for most thrombotic events in the neonate. OBJECTIVE: Investigate CRT frequency, association with days of catheter use until diagnosis, and number of catheters used, in a single-center Neonatal Intensive Care Unit. METHODS: A case-control study that included 14 cases and 42 controls. Data collection occurred between January 2017 and December 2020 in a public NICU. Crude odds ratios (COR) were calculated. The study complied with ethical standards from national guidelines. RESULTS: Two hundred and ninety-four neonates used central venous catheters, of which 14 (4.7%) were diagnosed with CRT. Catheter in use when diagnosis was made was centrally inserted central catheters in 8 (57.1%). Before diagnosis, the cumulative duration of catheter use was 34.5 days and the median number of catheters used was three. A higher SNAPPE-II (COR 1.03; 95% CI 1.01-1.06; p=0.03), cumulative days of catheter use >30 (COR 19.11; 95% CI 2.28-160.10; p=0.007) and number of catheters used ≥3 (COR 7.66; 95% CI 1.51-38.70; p=0.01) were associated with CRT. CONCLUSION: CRT cases were associated with clinical severity; number of catheters and cumulative days of catheter use. We suggest that screening for thrombosis should be performed in neonates who need a long time of catheter use and more than three catheters. Reducing the duration and number of venous catheters used will help to reduce CRT.

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INTRODUÇÃO: A trombose relacionada ao cateter (TRC) é responsável pela maioria dos eventos trombóticos no neonato. OBJETIVO: Investigar a frequência da TRC, a associação com os dias de uso do cateter até o diagnóstico e o número de cateteres utilizados em uma Unidade de Terapia Intensiva Neonatal unicêntrico. MÉTODOS: Estudo caso-controle que incluiu 14 casos e 42 controles. A coleta de dados ocorreu entre janeiro de 2017 e dezembro de 2020 em uma UTIN pública. Foram calculadas razões de chances brutas (COR). O estudo respeitou os padrões éticos das diretrizes nacionais. RESULTADOS: Duzentos e noventa e quatro neonatos utilizaram cateter venoso central, dos quais 14 (4,7%) foram diagnosticados com TRC. O cateter em uso no momento do diagnóstico foi o cateter central inserido centralmente em 8 (57,1%). Antes do diagnóstico, o tempo acumulado de uso do cateter foi de 34,5 dias e a mediana do número de cateteres utilizados foi de três. Um maior número de dias de uso do cateter >30 (COR 19,11; IC 95% 2,28-160,10; p=0,007) e número de cateteres utilizados >3 (COR 7,66; IC 95% 1,51-38,70; p=0,01). CONCLUSÃO: Os casos de TRC foram associados à gravidade clínica; número de cateteres e dias cumulativos de uso do cateter. Sugerimos que o rastreamento de trombose seja realizado em neonatos que necessitem de longo tempo de uso do cateter e mais de três cateteres. Reduzir a duração e o número de cateteres venosos usados ajudará a reduzir a TRC.

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Humanos , Recién Nacido , Unidades de Cuidado Intensivo Neonatal , Trombosis de la Vena , Catéteres Venosos Centrales , Estudios de Casos y Controles

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The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95-3.90 µg mL-1) and potent antioxidant activity in the DPPH (1.74±0.07 µg mL-1), FRAP (654.01±42.09 µmol ETrolox/gsample), and ORAC (3698.88±37.28 µmol ETrolox/gsample) methods. The EE displayed inhibition against the α-amylase enzyme (8.42±0.05 µg mL-1). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (-)-HPLC-ESI-MS/MS analysis, were found to contribute to the species' biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.

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Antibacterianos , Antifúngicos , Antioxidantes , Hipoglucemiantes , Melastomataceae , Pruebas de Sensibilidad Microbiana , Extractos Vegetales , Hojas de la Planta , Hojas de la Planta/química , Extractos Vegetales/química , Extractos Vegetales/farmacología , Extractos Vegetales/aislamiento & purificación , Melastomataceae/química , Antioxidantes/farmacología , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Antifúngicos/farmacología , Antifúngicos/química , Antifúngicos/aislamiento & purificación , Antibacterianos/farmacología , Antibacterianos/química , Antibacterianos/aislamiento & purificación , Hipoglucemiantes/farmacología , Hipoglucemiantes/química , Hipoglucemiantes/aislamiento & purificación , Candida/efectos de los fármacos , alfa-Amilasas/antagonistas & inhibidores , alfa-Amilasas/metabolismo , Flavonoides/química , Flavonoides/farmacología , Flavonoides/aislamiento & purificación , Cromatografía Líquida de Alta Presión

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PURPOSE: To analyze the sensation of pain and the range of mandibular movements of adult individuals with temporomandibular disorder, before and after the application of the athletic tape. METHOD: This is a double-blind randomized clinical trial, in which 22 adults with temporomandibular disorder participated, randomly allocated into two groups, with group A comprising 10 women and one man (mean age 28.2±8.3 years) and group B comprising nine women and two men (mean age 26.2±3.9 years). Group A was submitted to the application of the athletic tape on the masseter with 40% stretch and the group B to the application of the athletic tape on the masseter without stretching. All participants underwent the application of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Pain threshold assessment was performed using an algometer to apply pressure to measurement points. The measurement of mandibular movements was performed using a caliper. The athletic tape was glued using the I technique, with a fixed point over the insertion and a movable point over the origin of the masseter muscle. Participants remained with the athletic tape for 24 hours and were re-evaluated. RESULTS: There was pain relief in the group A in the temporomandibular joint on the right and at the origin of the masseter on the left. The group B showed a reduction in pain in the left anterior temporal region. No differences were found in mandibular movements after intervention, as well as no difference was found in the comparison by groups. CONCLUSION: The use of the athletic tape over the masseter muscle, with stretching, for 24 hours produced relief from the sensation of pain, on the origin of the right masseter and in the right temporomandibular joint, and, without stretching, in the left anterior temporal muscle. There was no difference in the range of mandibular movements.

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OBJETIVO: Analisar a sensação de dor e amplitude dos movimentos mandibulares de indivíduos adultos com disfunção temporomandibular, antes e após aplicação da bandagem elástica por 24 horas. MÉTODO: Trata-se de um ensaio clínico randomizado duplo-cego, do qual participaram 22 sujeitos adultos com disfunção temporomandibular, alocados aleatoriamente em dois grupos, sendo grupo A composto por 10 mulheres e um homem (média de idade de 28,2±8,3 anos) e grupo B por nove mulheres e dois homens (média de idade de 26,2±3,9 anos). Todos os participantes foram submetidos à aplicação do Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Foi realizada a avaliação do limiar da dor, com uso de um algômetro, para aplicação da pressão no masseter e temporal e medição dos movimentos mandibulares, com paquímetro. O grupo A foi submetido à aplicação da bandagem sobre o músculo masseter com estiramento de 40% e o grupo B sem estiramento. A colagem da bandagem foi realizada, com corte em "I", com ponto fixo sobre a inserção e ponto móvel sobre a origem do músculo masseter. Os participantes permaneceram com a bandagem por 24 horas e foram reavaliados. RESULTADOS: Houve alívio da dor no grupo A na articulação temporomandibular à direita e na origem do masseter à esquerda. O grupo B apresentou redução da dor em região de temporal anterior à esquerda. Não foram encontradas diferenças nos movimentos mandibulares após intervenção, bem como não houve diferença na comparação entre os grupos. CONCLUSÃO: O uso da bandagem sobre o masseter, por 24 horas, com estiramento, produziu alívio da dor na origem do masseter direito e na região da articulação temporomandibular direita e, sem estiramento, no temporal anterior esquerdo. Não houve diferença na amplitude de movimentos mandibulares.

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Cinta Atlética , Dolor Facial , Músculo Masetero , Dimensión del Dolor , Rango del Movimiento Articular , Trastornos de la Articulación Temporomandibular , Humanos , Femenino , Adulto , Método Doble Ciego , Masculino , Dolor Facial/fisiopatología , Dolor Facial/diagnóstico , Trastornos de la Articulación Temporomandibular/fisiopatología , Músculo Masetero/fisiopatología , Adulto Joven , Rango del Movimiento Articular/fisiología , Umbral del Dolor/fisiología , Mandíbula/fisiopatología

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The use of antimicrobials in swine production is an issue that concerns the whole world due to their impact on animal and public health. This study aimed to verify the antimicrobial use in 29 commercial full-cycle farms in the midwestern region of the state of Minas Gerais, since this region is a hub of intensive pig farming in Brazil, as well as the possible correlations between the use of antimicrobials, biosecurity, and productivity. A total of 28 different drugs used for preventive purposes were described. On average, the herds used seven drugs, exposing the piglets for 116 days and totaling 434.17 mg of antimicrobials per kilogram of pig produced. Just eight active ingredients made up 77.5% of the total number of drugs used on the studied herds. Significant differences were found between the variables, biosecurity score and number of sows, antimicrobial amount and number of drugs, number of drugs and number of sows, and between productivity and biosecurity scores. The use of antimicrobials was considered excessive in the swine farms in the state of Minas Gerais compared to what was reported in Brazil and in other countries. Educational measures and better control should be proposed to reduce the preventive use of antimicrobials.

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The aim of this study was to develop and validate regression models to predict the chemical composition and ruminal degradation parameters of corn silage by near-infrared spectroscopy (NIR). Ninety-four samples were used to develop and validate the models to predict corn silage composition. A subset of 23 samples was used to develop and validate models to predict ruminal degradation parameters of corn silage. Wet chemistry methods were used to determine the composition values and ruminal degradation parameters of the corn silage samples. The dried and ground samples had their NIR spectra scanned using a poliSPECNIR 900-1700 model NIR sprectrophotometer (ITPhotonics S.r.l, Breganze, IT.). The models were developed using regression by partial least squares (PLS), and the ordered predictor selection (OPS) method was used. In general, the regression models obtained to predict the corn silage composition (P>0.05), except the model for organic matter (OM), adequately estimated the studied properties. It was not possible to develop prediction models for the potentially degradable fraction in the rumen of OM and crude protein and the degradation rate of OM. The regression models that could be obtained to predict the ruminal degradation parameters showed correlation coefficient of calibration between 0.530 and 0.985. The regression models developed to predict CS composition accurately estimated the CS composition, except the model for OM. The NIR has potential to be used by nutritionists as a rapid prediction tool for ruminal degradation parameters in the field.

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Ensilaje , Zea mays , Animales , Ensilaje/análisis , Espectroscopía Infrarroja Corta , Rumen/metabolismo , Digestión , Fermentación , Dieta

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INTRODUCTION: Suicide is a worldwide health concern and up to date there is no good predictor of it except a previous suicide attempt. Therefore, there are increasing efforts in the understanding of which factors, genetic or environmental, are associated with suicide behaviour. OBJECTIVE: To review evidence of the effect of childhood trauma and impulsivity on suicidal behavior through a systematic review and meta-analysis. METHODS: Searches were conducted on the 12th of June 2021 in the PubMed, Scopus, and Web of Science databases. Two reviewers evaluated each record for eligibility and discussed upon disagreement, when no consensus was reached, a third reviewer was involved to make a decision. RESULTS: A total of 11,530 records were identified through the searches. After duplicates were removed, 6,595 records remained to be screened. The full text was sought for 1,561 records. Our qualitative synthesis included 22 studies, from which 9 were included in the meta-analyses. We found a significant effect of sexual abuse, physical abuse, emotional abuse and physical neglect on suicide attempts in the prisoners, and Substance Use Diorder (SUD) subgroups. Moreover, there was a significant effect of Childhood Trauma Questionnaire (CTQ) total score and emotional neglect dimension for all the subgroups. CONCLUSION: The present study has provided an overview of the state-of-the-art research on childhood trauma and impulsivity and their association with suicidal behavior and quantified their effects on suicide attempts. Hopefully this evidence will be considered in future research and harnessed for clinical gain in detection and treatment of suicide behaviour.

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Fluoxetine is an antidepressant used to treat several conditions including postpartum depression. This disease causes cognitive, emotional, behavioral and physical changes, negatively affecting the mother, child and family life. However, fluoxetine is excreted in breast milk, causing short and long-term effects on children who were exposed to the drug during lactation, so studies that seek to uncover the consequences of these effects are needed. Thus, the aim of this study was to evaluate the effects of fluoxetine on the nutritional characteristics of milk and on growth and neurobehavioral development of the offspring on a rat model. Lactating rats were divided into 4 groups: control group and three experimental groups, which were treated with different doses of fluoxetine (1, 10 and 20 mg/kg) during the lactation. Dams body weight and milk properties were measured, as well as offspring's growth and physical and neurobehavioral development. Results showed that the use of fluoxetine during lactation decreased dam's body weight and alters milk's properties, leading to a decrease in offspring's growth until adulthood. Therefore, the use of fluoxetine during lactation needs to be cautiously evaluated, with the benefits to the mothers and the associated risk to the offspring carefully balance.

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Fluoxetina , Lactancia , Humanos , Femenino , Niño , Ratas , Animales , Adulto , Fluoxetina/toxicidad , Leche Humana , Antidepresivos/farmacología , Peso Corporal

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Overcoming senescence with tissue engineering has a promising impact on multiple diseases. Here, we provide an overview of recent studies in which cellular senescence was inhibited through the up/downregulation of specific lncRNAs. This approach prevented senescence in the bones, joints, nervous system, heart, and blood vessels, with a potential impact on regeneration and the prevention of osteoarthritis and osteoporosis, as well as neurodegenerative and cardiovascular diseases. Senescence of the skin and liver could also be prevented through the regulation of cellular levels of specific lncRNAs, resulting in the rejuvenation of cells from these organs and their potential protection from disease. From these exciting achievements, which support tissue regeneration and are not restricted to stem cells, we propose lncRNA regulation through RNA or gene therapies as a prospective preventive and therapeutic approach against aging and multiple aging-related diseases.

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Enfermedades Cardiovasculares , ARN Largo no Codificante , Humanos , ARN Largo no Codificante/genética , Estudios Prospectivos , Piel

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OBJETIVO: Analisar o sofrimento psíquico de trabalhadores dos serviços de saúde mental em contexto pandêmico e identificar os fatores associados. MÉTODO: Pesquisa transversal, com 108 trabalhadores de quatro serviços de saúde mental de um município do interior paulista. Coleta de dados realizada on-line entre outubro e dezembro de 2020 por meio de questionário sociodemográfico e Escala Self Report Questionnaire-20 (SRQ-20). Os dados foram analisados por estatística descritiva e por regressão linear múltipla de mínimos quadrados ordinários, na intenção de analisar os fatores associados para a variação no escore da escala. RESULTADOS: Os trabalhadores apresentaram média elevada na escala SRQ-20 (15,07), o que indica grande sofrimento psíquico. Fazer acompanhamento psicológico e/ou psiquiátrico durante a pandemia de covid-19 esteve associado à minimização deste sofrimento, com redução de, em média, três dos sintomas avaliados pela escala. CONCLUSÃO: O acompanhamento em saúde mental para os trabalhadores no contexto pandêmico pode ser uma importante estratégia de enfrentamento associada à redução do sofrimento psíquico.

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OBJECTIVE: To analyze the psychological distress of mental health workers in a pandemic context and identify associated factors. METHOD: A cross-sectional study was conducted with 108 workers from four mental health services in a municipality in the interior of São Paulo. Data was collected online between October and December 2020 through a sociodemographic questionnaire and the Self Report Questionnaire-20 (SRQ-20) scale. The data were analyzed using descriptive statistics and multiple linear regression of ordinary least squares to analyze the factors associated with the variation in the scale score. RESULTS: The workers had a high average on the SRQ-20 scale (15.07), indicating significant psychological distress. Receiving psychological and/or psychiatric support during the COVID-19 pandemic was associated with reducing this distress, with an average reduction of three symptoms assessed by the scale. CONCLUSION: Mental health support for workers in the pandemic context can be an important coping strategy associated with reducing psychological distress.

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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Salud Mental , Personal de Salud , Distrés Psicológico , COVID-19 , Servicios de Salud Mental , Estudios Transversales

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Resumen Objetivo validar el instrumento de cuidado perdido de enfermería (MISSCARE), para ser utilizado en contexto chileno. Método adaptación sociolingüística de MISSCARE a través de traducción y retrotraducción, seguida por evaluación de profesionales de enfermería con manejo de idioma inglés y finalmente validación de contenido a través de revisión, adecuación cultural y de contenido, por expertos del área. Resultados el instrumento en su versión 2.0 demostró validez aparente y de contenido. El cuidado de enfermería perdido es un evento adverso que amenaza la seguridad y calidad de la atención en salud. Contar con un instrumento validado que mida el cuidado perdido será un indicador para mejorar la calidad en la atención prestada. Conclusiones e implicaciones para la práctica el instrumento MISSCARE en su versión adaptada es una herramienta confiable y válida para medir el cuidado perdido en instituciones hospitalarias. Estudiar los cuidados omitidos generará conocimientos clave para mejorar la calidad de la atención en salud y desarrollar indicadores de gestión. Estos conocimientos impulsarán estrategias e intervenciones para optimizar servicios y garantizar un estándar más alto en la atención.

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Resumo Objetivo validar o instrumento MISSCARE para uso no contexto chileno. Método a adaptação sociolinguística do MISSCARE envolveu tradução e retrotradução, seguida por avaliação de enfermeiros falantes de inglês. Finalmente, a validação de conteúdo foi alcançada por meio de revisão por especialistas, com foco na adaptação cultural e de conteúdo. Resultados a versão 2.0 do MISSCARE demonstrou validade de face e de conteúdo. O cuidado perdido é um evento adverso que ameaça a segurança e a qualidade da assistência à saúde. Ter um instrumento validado para medir o cuidado perdido servirá como um indicador para melhorar a qualidade da assistência à saúde prestada. Conclusão e implicações para a prática a versão adaptada do MISSCARE é uma ferramenta confiável e válida para medir o cuidado de enfermagem perdido em hospitais. O estudo do cuidado de enfermagem perdido gerará conhecimento essencial para melhorar a qualidade da assistência à saúde e desenvolver indicadores de gestão. Esses insights impulsionarão estratégias e intervenções para otimizar os serviços e garantir um padrão mais elevado de atendimento.

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Abstract Objective to validate the MISSCARE instrument for use in the Chilean context. Method sociolinguistic adaptation of MISSCARE involved translation and back-translation, followed by evaluation by English-speaking nurses. Finally, content validation was achieved through expert review, focusing on cultural and content adaptation. Results the 2.0 version of MISSCARE demonstrated both face and content validity. Missed care is an adverse event that threatens the safety and quality of health care. Having a validated instrument to measure missed care will serve as an indicator to improve the quality of health care provided. Conclusions and implications for practice the adapted version of MISSCARE is a reliable, valid tool for measuring missed nursing care in hospitals. The study of missed nursing care will generate essential knowledge to improve the quality of health care and to develop management indicators. These insights will drive strategies and interventions in order to optimize services and ensure a higher standard of care.

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Humanos , Femenino , Encuestas y Cuestionarios , Traducción , Seguridad del Paciente , Atención de Enfermería/métodos , Atención de Enfermería/organización & administración

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Resumo Objetivos estimar a prevalência de depressão em pessoas idosas do Brasil e os fatores associados, e descrever características do uso de serviços de saúde e tratamentos de saúde dispensados aos idosos com depressão. Método Estudo transversal, analítico, com 22.728 pessoas idosas participantes da Pesquisa Nacional de Saúde (PNS), selecionadas aleatoriamente no Brasil, no período de agosto de 2019 a março de 2020. O desfecho foi o autorrelato de depressão e as exposições foram as variáveis sociodemográficas e um escore de rede social. Foram empregadas análises descritivas e múltiplas por meio de regressão logística. Resultados A prevalência de depressão autorrelatada pelas pessoas idosas foi de 11,8% (IC95%: 11,1-12,57). Observou-se que 71,6% (IC95%: 67,9-75,0) da população idosa com depressão faz apenas tratamento medicamentoso. Houve maior chance de depressão entre idosas (OR=2,46; IC95%: 2,06-2,94), de 60 a 69 anos (OR=1,67; IC95%: 1,31-2,14); de cor de pele branca (OR=2,95; IC95%: 1,62-5,39), moradores da região Sul (OR=3,01; IC95%: 2,27-4,00) e com multimorbidade (OR=1,79; IC95%: 1,49-2,14). Conclusão A depressão apresentou-se com frequência considerável entre pessoas idosas, especialmente entre mulheres. Há necessidade de incentivo a adoção de medidas não farmacológicas para tratamento da doença, tais como, uso de práticas integrativas e complementares atividades físicas, mudanças no estilo de vida e fomento a atividades sociais.

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Abstract Objectives To estimate the prevalence of depression among older adults in Brazil and the associated factors, and to describe the characteristics of health service utilization and treatments provided to older adults with depression. Method A cross-sectional, analytical study involving 22,728 older adults who participated in the National Health Survey (PNS), randomly selected across Brazil from August 2019 to March 2020. The outcome was self-reported depression, and the exposures were sociodemographic variables and a social network score. Descriptive and multiple analyses using logistic regression were employed. Results The prevalence of self-reported depression among older adults was 11.8% (95% CI: 11.1-12.57). It was observed that 71.6% (95% CI: 67.9-75.0) of the older population with depression only undergoes pharmacological treatment. There was a higher likelihood of depression among older women (OR=2.46; 95% CI: 2.06-2.94), aged 60 to 69 years (OR=1.67; 95% CI: 1.31-2.14), with white skin color (OR=2.95; 95% CI: 1.62-5.39), residents of the South region (OR=3.01; 95% CI: 2.27-4.00), and with multimorbidity (OR=1.79; 95% CI: 1.49-2.14). Conclusion Depression appeared with considerable frequency among older adults, especially among women. There is a need to encourage the adoption of non-pharmacological measures for the treatment of the condition, such as the use of integrative and complementary practices, physical activities, lifestyle changes, and the promotion of social activities.

RESUMEN

Objetivo: mapear intervenções de enfermagem no manuseio da dor crônica em adultos e idosos em cuidados paliativos. Método: trata-se de um protocolo de revisão de escopo, alicerçado nas diretrizes do Joanna Briggs Institute e nas recomendações do Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. Serão utilizadas cinco bases de dados: MEDLINE/PubMed, Scopus, Web of Science, CINAHAL e National Grey Literature Collection, utilizando os descritores em saúde, a fim de responder a pergunta de pesquisa: "Quais intervenções de enfermagem são realizáveis no cuidado da dor crônica em indivíduos adultos e idosos em cuidados paliativos no campo da Enfermagem?" O processo de busca, identificação e avaliação será realizado por dois avaliadores independentes. Serão incluídos artigos nos idiomas inglês, português e espanhol, que atendiam ao objetivo. Os dados serão incluídos em uma planilha previamente construída e apresentados em tabelas, figuras e diagramas.

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Objetivo: mapear las intervenciones de enfermería en el manejo del dolor crónico en adultos y adultos mayores en cuidados paliativos. Método: se trata de un protocolo de revisión exploratoria, basado en las directrices del Joanna Briggs Institute y las recomendaciones de los Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. Se utilizarán cinco bases de datos: MEDLINE/PubMed, Scopus, Web of Science, CINAHL y National Grey Literature Collection, utilizando los descriptores de salud, con el fin de responder a la pregunta de investigación: "¿Qué intervenciones de enfermería son alcanzables en el cuidado del dolor crónico en adultos y ancianos en cuidados paliativos en el campo de la Enfermería?" El proceso de búsqueda, identificación y evaluación estará a cargo de dos evaluadores independientes. Se incluirán artículos en inglés, portugués y español, que cumplieron con el objetivo. Los datos se incluirán en una hoja de cálculo previamente construida y se presentarán en tablas, figuras y diagramas.

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Objective: mapping nursing interventions in the management of chronic pain in adults and elderly in palliative care. Method: this is a scope review protocol, based on the guidelines of the Joanna Briggs Institute and the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. Five databases will be used: MEDLINE/PubMed, Scopus, Web of Science, CINAHL and National Grey Literature Collection, using the descriptors in health, to answer the research question: "Which nursing interventions are feasible in the care of chronic pain in adults and elderly in palliative care in the field of Nursing?" The search, identification and evaluation process will be performed by two independent evaluators. Articles in English, Portuguese and Spanish will be included, which met the objective. The data will be included in a previously constructed spreadsheet and presented in tables, figures and diagrams.

Asunto(s)

Humanos , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Cuidados Paliativos/métodos , Dolor Crónico/enfermería , Manejo del Dolor/métodos , Proceso de Enfermería/tendencias

RESUMEN

ABSTRACT The Removable Partial Denture stands as an effective rehabilitation choice for patients who have undergone partial maxillectomy surgery due to maxillary tumors, involving the partial surgical removal of the maxillary bone. Removable partial denture are meticulously designed to restore masticatory, phonetic, and aesthetic functions, thereby contributing significantly to enhancing self-esteem and aiding patients in resuming social activities. During the patient's history-taking phase, it is of paramount importance to assess the patient's overall health, psychological state, expectations, and limitations. Ensuring regular follow-ups is imperative to prevent complications and to guarantee the durability of the prosthesis. Prosthetic planning constitutes a critical phase and can pose challenges, especially in achieving proper retention, stability, and suitable supports. Factors such as the defect size, the number of remaining teeth, and the amount of remaining bone structures can influence the treatment prognosis. It is crucial to emphasize that lack of adequate planning can lead to rehabilitation failures, resulting in discomfort, compromised functionality, and even potential harm to the patient's health. In this context, this study aims to present a successful clinical case of a patient who underwent partial maxillectomy and was rehabilitated through a Removable Partial Denture fixed with clasps on the entire left upper hemi-arch. This case vividly illustrates the importance of a personalized approach to prosthetic rehabilitation in patients with partial maxillectomy, taking into account the specificities of each case and highlighting the necessity of interdisciplinary collaboration to achieve satisfactory outcomes.

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RESUMO A prótese parcial removível é uma opção eficaz de reabilitação para pacientes que passaram por cirurgia de maxilectomia parcial em decorrência de tumores maxilares, ou seja, remoção cirúrgica parcial do osso maxilar. A prótese parcial removível deve ser projetada para recuperar as funções mastigatória, fonética e estética, contribuindo assim na melhoria da autoestima e ajudando o paciente a retornar às atividades sociais. Durante a anamnese, é de grande importância verificar o estado geral e psicológico do paciente, suas expectativas e limitações, garantir o acompanhamento frequente para evitar complicações e garantir a durabilidade da prótese. O planejamento protético é uma etapa crítica e pode apresentar desafios, especialmente na obtenção de retenção, estabilidade e suportes adequados. Fatores como o tamanho do defeito, o número de dentes remanescentes e a quantidade de estruturas ósseas remanescentes podem interferir no prognóstico do tratamento. É importante ressaltar que a falta de planejamento pode levar a falhas na reabilitação, resultando em desconforto, má funcionalidade e até mesmo danos à saúde do paciente. Nesse contexto, o presente trabalho tem como objetivo apresentar um caso clínico de sucesso de uma paciente que foi submetida a uma maxilectomia parcial e reabilitada por meio de uma prótese parcial removível fixada por grampos em todo o hemiarco superior esquerdo. Este caso ilustra a importância de uma abordagem personalizada para a reabilitação protética em pacientes com maxilectomia parcial, considerando as particularidades de cada caso e a colaboração interdisciplinar para a obtenção de resultados satisfatórios.

RESUMEN

RESUMO Objetivo Analisar a sensação de dor e amplitude dos movimentos mandibulares de indivíduos adultos com disfunção temporomandibular, antes e após aplicação da bandagem elástica por 24 horas. Método Trata-se de um ensaio clínico randomizado duplo-cego, do qual participaram 22 sujeitos adultos com disfunção temporomandibular, alocados aleatoriamente em dois grupos, sendo grupo A composto por 10 mulheres e um homem (média de idade de 28,2±8,3 anos) e grupo B por nove mulheres e dois homens (média de idade de 26,2±3,9 anos). Todos os participantes foram submetidos à aplicação do Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Foi realizada a avaliação do limiar da dor, com uso de um algômetro, para aplicação da pressão no masseter e temporal e medição dos movimentos mandibulares, com paquímetro. O grupo A foi submetido à aplicação da bandagem sobre o músculo masseter com estiramento de 40% e o grupo B sem estiramento. A colagem da bandagem foi realizada, com corte em "I", com ponto fixo sobre a inserção e ponto móvel sobre a origem do músculo masseter. Os participantes permaneceram com a bandagem por 24 horas e foram reavaliados. Resultados Houve alívio da dor no grupo A na articulação temporomandibular à direita e na origem do masseter à esquerda. O grupo B apresentou redução da dor em região de temporal anterior à esquerda. Não foram encontradas diferenças nos movimentos mandibulares após intervenção, bem como não houve diferença na comparação entre os grupos. Conclusão O uso da bandagem sobre o masseter, por 24 horas, com estiramento, produziu alívio da dor na origem do masseter direito e na região da articulação temporomandibular direita e, sem estiramento, no temporal anterior esquerdo. Não houve diferença na amplitude de movimentos mandibulares.

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ABSTRACT Purpose To analyze the sensation of pain and the range of mandibular movements of adult individuals with temporomandibular disorder, before and after the application of the athletic tape. Method This is a double-blind randomized clinical trial, in which 22 adults with temporomandibular disorder participated, randomly allocated into two groups, with group A comprising 10 women and one man (mean age 28.2±8.3 years) and group B comprising nine women and two men (mean age 26.2±3.9 years). Group A was submitted to the application of the athletic tape on the masseter with 40% stretch and the group B to the application of the athletic tape on the masseter without stretching. All participants underwent the application of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Pain threshold assessment was performed using an algometer to apply pressure to measurement points. The measurement of mandibular movements was performed using a caliper. The athletic tape was glued using the I technique, with a fixed point over the insertion and a movable point over the origin of the masseter muscle. Participants remained with the athletic tape for 24 hours and were re-evaluated. Results There was pain relief in the group A in the temporomandibular joint on the right and at the origin of the masseter on the left. The group B showed a reduction in pain in the left anterior temporal region. No differences were found in mandibular movements after intervention, as well as no difference was found in the comparison by groups. Conclusion The use of the athletic tape over the masseter muscle, with stretching, for 24 hours produced relief from the sensation of pain, on the origin of the right masseter and in the right temporomandibular joint, and, without stretching, in the left anterior temporal muscle. There was no difference in the range of mandibular movements.