RESUMEN

Antibody-negative hepatitis C virus (HCV) infection, defined by the presence of HCV viremia in the absence of a serologic response to HCV, was detected in two immunocompetent and symptom-free children; each had a history of exposure to blood products. HCV infection may occasionally explain cryptogenic elevation of aminotransferases, even in the absence of serum anti-HCV. HCV-RNA should be investigated in these cases, particularly in the presence of previous exposure to blood products.

Asunto(s)

Hepacivirus/inmunología , Anticuerpos contra la Hepatitis C/sangre , Hepatitis C Crónica/diagnóstico , Adolescente , Alanina Transaminasa/sangre , Transfusión Sanguínea , Ensayo de Inmunoadsorción Enzimática , Femenino , Hepatitis C Crónica/etiología , Hepatitis C Crónica/inmunología , Humanos , Inmunización Pasiva , Immunoblotting , Inmunocompetencia , Lactante , Masculino , Reacción en Cadena de la Polimerasa , Viremia/inmunología , Viremia/virología