RESUMEN
Chromomycosis is a disfiguring cutaneous mycosis that is often recalcitrant to therapy. We describe a case of chromomycosis of the lower extremities that is being successfully treated with ketoconazole and 5-fluorocytosine (5-FC) after treatment with ketoconazole alone had failed. In vitro studies showed that the drugs acted synergistically against the strain of Fonsecaea pedrosoi which was isolated from the patient's lesion.
Asunto(s)
Antifúngicos/administración & dosificación , Cromoblastomicosis/tratamiento farmacológico , Imidazoles/administración & dosificación , Piperazinas/administración & dosificación , Adulto , Cromoblastomicosis/patología , Sinergismo Farmacológico , Quimioterapia Combinada , Humanos , Cetoconazol , Masculino , Piel/patologíaRESUMEN
We have reported two cases of localized BP without antibody or complement detectable at the BMZ. Several lines of evidence are discussed suggesting that the presence of immunoglobulin and complement at the BMZ serves as a convenient laboratory marker and does not play an etiologic role. This evidence includes the lack of production of a blister by BP serum in organ culture, the high incidence of immune complexes in BP patients, and the spontaneous increase in autoantibody in the elderly. It is suggested that autoantibody production (specifically anti-basement membrane zone antibody) may occur in BP as a marker of this disease without etiologic significance.