RESUMEN
[Formula see text], their profile can be one of markers, characterizing activity of colon microflora at the consequences of the vast resections of bowels, and to determine setting of preparations of medicamental correction in the structure of nutritional therapy by siping compositions.
Asunto(s)
Intestino Delgado/cirugía , Apoyo Nutricional , Síndrome del Intestino Corto , Adulto , Cromatografía Liquida , Ácidos Grasos Volátiles/análisis , Estudios de Seguimiento , Humanos , Intestino Grueso/microbiología , Cuidados Posoperatorios , Índice de Severidad de la Enfermedad , Síndrome del Intestino Corto/dietoterapia , Síndrome del Intestino Corto/etiología , Resultado del TratamientoRESUMEN
One of the main components of the metabolic syndrome is a non-alcoholic fatty liver disease (NAFLD). Currently, NAFLD is recognized as one of the main factors for cardiovascular disease because cholesterol synthesis is carried out mainly in the liver. In connection with this selection of lipid-lowering therapy, which has a known hepatotoxic effect, is a challenge. In the pathogenesis of NAFLD important role played by the violation of the colon microflora and, consequently, elevated levels of metabolic products of microorganisms (short chain fatty acids, endotoxin, nitric oxide), which must also be considered in the treatment of atherogenic dyslipidemia. In patients with NAFLD and atherogenic dyslipidemia appointment of combination therapy of statins and probiotics are more effective in lowering cholesterol and products of metabolism of intestinal microflora compared with monotherapy.
Asunto(s)
Aterosclerosis/prevención & control , Dislipidemias/tratamiento farmacológico , Hígado Graso/tratamiento farmacológico , Hipolipemiantes/uso terapéutico , Intestino Grueso/microbiología , Probióticos/uso terapéutico , Adulto , Anciano , Aterosclerosis/etiología , Aterosclerosis/microbiología , Biopsia , Colesterol/sangre , Interpretación Estadística de Datos , Quimioterapia Combinada , Dislipidemias/metabolismo , Dislipidemias/microbiología , Dislipidemias/patología , Hígado Graso/metabolismo , Hígado Graso/microbiología , Hígado Graso/patología , Femenino , Humanos , Hipolipemiantes/administración & dosificación , Pruebas de Función Hepática , Masculino , Persona de Mediana Edad , Probióticos/administración & dosificación , Resultado del TratamientoRESUMEN
AIM: To specify characteristics of biochemical bile composition contributing to destabilization of colloid properties of bile in patients with biliary "sludge". MATERIAL AND METHODS: 37 patients with "sludge" in the gallbladder (GB), 10 patients with cholelithiasis and 10 patients with intact GB participating in the study were examined for bile portion B bile acids (BA), cholesterol and phospholipids (PL); lipid and lipoprotein blood composition. RESULTS: Three types of biochemical composition of bile in GB "sludge" patients were identified. 22 patients had elevated levels of cholesterol and PL in subnormal content of BA (group 1); 9 patients had normal FA and cholesterol, low content of biliary PL (group 2); 6 patients had normal concentrations of the three components (group 3). Blood lipids were characterized by elevated levels of total cholesterol and LDLP cholesterol in group 1; low HDLP cholesterol and triglycerides in group 2 and almost normal values in group 3. Basing on these data, causes of "sludge" formation in the GB are suggested. CONCLUSION: Biliary "sludge" may form because of excessive cholesterol in bile, low phospholipid levels or in normal proportion of the studied substances.