RESUMEN
A pedagogical experiment was used to study the effectiveness of a system of program-purpose teaching in postgraduate training of radiologists differing from the classic methods aimed at end goals. A total of 150 pedagogical tests on 240 students using parallel and cross methods were performed. The use of the system of program-purpose teaching intensifies the physician's activities, increases the effectiveness of acquiring professional habits and their retention.
Asunto(s)
Educación de Postgrado en Medicina , Radiología/educación , Enseñanza , Evaluación Educacional , U.R.S.S.RESUMEN
The interaction of 11 overlapping synthetic peptides corresponding to N-terminal segment of HIV transmembrane glycoprotein gp41 (fusion domain) with artificial lipid membranes has been studied. For this purpose the increase of a bilayer lipid membrane (BLM) conductivity and the changes in ESR spectra of spin-labelled liposomes were registrated. Peptide fragment 523-532 gp160 (BRU strain) had the critical length with regard to channel-forming activity on BLM. The degree of such membranotropic action increased simultaneously with the growth of peptide length and the temperature in the cell. Peptides 518-532 and 517-532 lysed TEMPOcholine-containing liposomes at 37 degrees C. The significance of observed effects for explanation of the mechanism of HIV-induced membrane fusion is discussed.
Asunto(s)
Proteína gp41 de Envoltorio del VIH/metabolismo , VIH-1/metabolismo , Membrana Dobles de Lípidos/metabolismo , Proteínas Virales de Fusión/metabolismo , Secuencia de Aminoácidos , Espectroscopía de Resonancia por Spin del Electrón , Potenciales de la Membrana , Datos de Secuencia Molecular , Péptidos/síntesis química , Fosfatidilcolinas/metabolismo , Fosfatidiletanolaminas/metabolismoRESUMEN
The paper is devoted to the development of a system of program-oriented postgraduate education of radiologists based methodologically on acquiring professional knowledge and skills. Educational goals were adapted for each subject area. Matrix analysis and plotting of a logical structure graph were used for a choice of the final goals of education. The subject matter is in full accord with the educational goals, based upon the qualification characteristics of radiologists. The developed and published methodological materials make it possible to control the students' activities during extracurricular training and practical work in x-ray units and at seminars. Directed text control is used for the estimation of efficacy and correction of education.