RESUMEN

Experiments on rats showed that the increased use of NaCl modulates the renal activity of enalapril. In animals with a model edema syndrome caused by subdiaphragm constriction of the interior vena cava, a hyper-NaCl diet enhances the Na-diuretic action of enalapril in both subacute and chronic stage of circulation insufficiency. In addition, enalapril increases the creatinin secretion in rats with this model (but not in intact animals). The administraton of enalapril in animals with caval obstruction receiving excess NaCl, in contrast to the case of standard diet, decreases the consumption of water, thus preventing the development of a positive balance of water.

Asunto(s)

Antihipertensivos/administración & dosificación , Diuréticos/administración & dosificación , Edema/tratamiento farmacológico , Enalapril/administración & dosificación , Equilibrio Hidroelectrolítico/efectos de los fármacos , Animales , Creatinina/orina , Modelos Animales de Enfermedad , Ingestión de Líquidos/efectos de los fármacos , Edema/inducido químicamente , Edema/patología , Masculino , Ratas , Cloruro de Sodio Dietético/efectos adversos , Cloruro de Sodio Dietético/farmacología , Síndrome , Vena Cava Inferior/patología