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BACKGROUND: Body Fat percentage (BFP) and body mass index (BMI) are used to measure obesity-related metabolic syndrome risk. The present study aimed to determine the values of percent body Fat and body mass index for predicting metabolic syndrome risk factors in diabetic patients of Yazd, Iran. METHODS: A total of 1022 (499 males and 523 females) diabetic patients participated in this study. According to Asian BMI criteria, Overweight was diagnosed if a participant had a BMI ≥25 kg/m2 (both male and female) or BFP ≥25% for male and ≥ 32% for female. Based on calculated BMI and BFP and after adjusting for age, height, weight and smoking habits, the participants were classified into group A (normal weight and Non-Fat), group B (overweight and Non-Fat), group C (normal weight and Fat), and group D (overweight and Fat). RESULTS: According to the results, the BMI of 23.4% were normal and BMI of 76.6% were overweight, respectively. Moreover, the BFP of 25.7 and 74.3% of the studied population were considered as Non-Fat and Fat, respectively. A strong relationship was found with respect to sex stratification; R2 = 0.79. For men, BMI can be a better predictor of hypertension and hypertriglyceridemia than BFP. For women, BMI was a better predictor of hyperglycemia than BFP. Moreover, BFP can be regarded as a better predictor of hyperglycemia in male group, while it was a good predictor of hypertension and hypertriglyceridemia and hypo HDL than BMI, in female group. CONCLUSION: Significant differences were observed between BMI and BFP to predict metabolic syndrome risk factors in diabetic patients across different sexes in our study population. In conclusion, both BMI and BFP should be considered in screening steps.

Asunto(s)

Diabetes Mellitus , Hiperglucemia , Hipertensión , Hipertrigliceridemia , Síndrome Metabólico , Tejido Adiposo , Índice de Masa Corporal , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/epidemiología , Femenino , Humanos , Irán/epidemiología , Masculino , Síndrome Metabólico/diagnóstico , Síndrome Metabólico/epidemiología , Síndrome Metabólico/etiología , Sobrepeso/complicaciones , Sobrepeso/epidemiología , Factores de Riesgo

RESUMEN

BACKGROUND: Thyroid dysfunction is associated with negative pregnancy outcomes. There is a lack of reliable information on thyroid hormones in Iranian pregnant women, especially in Yazd. OBJECTIVE: To determine the safe thyroid hormone levels in women of Yazd and also the first trimester-specific reference ranges for serum thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3). MATERIALS AND METHODS: In this cross-sectional study, the serum of 1,148 women in the first trimester of pregnancy was analyzed. Thyroid function tests (TSH, T4, T3) were measured through radioimmunoassay (RIA) [immunoradiometric (IRMA) for TSH]. The study was conducted in Yazd, from September 2018 to November 2019. Reference intervals were defined as the 5 th , 50 th , and 95 th percentiles. RESULTS: The mean age of the participants was 28.78 ( ± 5.86 yr) (range: 15-45 yr). The thyroid hormones reference intervals in the first trimester were TSH (0.2-3.8 mIU/l), T4 (7.45-12.75, µ g/dl), and T3 (100-217 ng/dl). CONCLUSION: The results of the present study determined a local thyroid function measurement in the first trimester of pregnancy at a center of Yazd, Iran. This could facilitate the decision-making of maternal TSH level during the first trimester of pregnancy.

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BACKGROUND: Chemical preservatives are now used in various foods to increase shelf life and maintain quality instead of its natural extracts with anti-bacterial properties from plants can be used. Hence this research was planned to evaluate and study the synergistic antibacterial effect of the methanolic extracts of Dracocephalum kotschyi (D. kotschyi) and Trachyspermum ammi (T. ammi) against standard pathogenic bacteria like: Pseudomonas aeruginosa (P. aeruginosa), Shigella dysenteriae (S. dysenteriae), Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). METHODS: The methanolic extract of D. kotschyi and T. ammi was prepared by the Soxhlet method. The minimum inhibitory concentration (MIC) of this methanolic extracts were determined by the microdilution method. Thus, by determining the amount of fractional inhibitory concentration index (FICI), the interaction between the methanolic extracts of D. kotschyi and T. ammi on the pathogenic bacteria was determined. RESULTS: In this study, the MIC of the extracts of D. kotschyi and T. ammi on the pathogen; S. aureus was equal to 6.25 mg/mL and 12.5 mg/mL for S. dysenteriae, E. coli and P. aeruginosa. Hence, the combination of methanolic extracts of these plants shows a synergistic antibacterial effect (FICI < 0.5), on all tested pathogenic microorganisms was proved. CONCLUSION: Due to the antimicrobial synergistic effect and cost-effective production process of methanolic extracts of D. kotschyi and T. ammi, they are used as natural preservatives and flavouring agents to preserve foods.

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BACKGROUND AND OBJECTIVES: Antibiotic resistance in Pseudomonas aeruginosa is an increasing health problem. Integrons are associated with a variety of gene cassettes, which confer resistance to multiple classes of antibiotics. This study aimed at screening the presence of class 1, 2 and 3 integrons in P. aeruginosa in Yazd, Iran. MATERIALS AND METHODS: This study was carried out on P. aeruginosa strains from March 2016 to March 2017. Clinical specimens were initially identified by the standard biochemical methods and their resistance patterns to antibiotics were studied using the disc diffusion method. PCR was carried out for the detection of class 1, 2 and 3 integrons using intI1, intI2 and intI3 gene primers, respectively. RESULTS: Antimicrobial susceptibility test showed that 75% of isolates were detected as multi-drug resistant (MDR), and lowest resistance was observed in ciprofloxacin (48.6%) and most resistance was in gentamicin (63.2%). Moreover, PCR results showed that 22 (15.3%) and 119 (82.6%) of P. aeruginosa isolates carried intI2 and intI1 genes, but intI3 gene was not found. CONCLUSION: Since it is customary to observe Class I integrons in P. aeruginosa isolated from clinical samples, they are often responsible for antibiotic resistance gene transfer, which calls for evaluation of integrons as contributing factors in antibiotic resistance.