RESUMEN
Biologic action was studied of the silicon nitride powder with varying disperse composition. When producing and using the silicon nitride powder on an enlarged scale one must remember of its higher toxicity and fibrogenicity. There is a need of employing some method of determination of the submicroscopic aerosol disperse composition under industrial conditions.
Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Compuestos de Silicona/toxicidad , Aerosoles , Contaminantes Ocupacionales del Aire/administración & dosificación , Animales , Polvo/efectos adversos , Pulmón/efectos de los fármacos , Pulmón/patología , Concentración Máxima Admisible , Tamaño de la Partícula , Polvos , Compuestos de Silicona/administración & dosificación , Factores de TiempoRESUMEN
Dust of mineral wool obtained from ferronickel slags was demonstrated to be capable of inducing moderate pneumofibrosis. Small contents of manganese, nickel, chrome and cobalt in the mineral wool particles necessitate further investigations for their probable mutagenic effect.
Asunto(s)
Compuestos de Calcio/toxicidad , Polvo/efectos adversos , Hierro/toxicidad , Níquel/toxicidad , Silicatos/toxicidad , Animales , Barrera Alveolocapilar/efectos de los fármacos , Pulmón/efectos de los fármacos , Pulmón/patología , Microscopía Electrónica , Fibrosis Pulmonar/inducido químicamente , Fibrosis Pulmonar/patología , Ratas , Factores de TiempoRESUMEN
The authors investigated the activity of alkaline phosphatase, alanine- and aspartate-aminotransferases of the blood serum, mitochondria and postmitochondrial fraction of the liver in conditions of administration of mineral cotton from ferronickel slag. It was shown that 1 and 3 months after introduction of mineral cotton dust changes occurred in the activity of these enzymes. Restoration of these enzymes occurred 6 months after introduction of mineral cotton dust.