RESUMEN
Twenty females with disseminated breast cancer received courses of polychemotherapy with 21-day intervals. The regimen comprised adriamycin (ADM), cyclophosphamide and 5-fluorouracil in the dose 50, 500 mg/m2, respectively. 30 minutes prior to the treatment the patients were given the cardioprotector cardioxan (1000 mg/m2). Cardiological control (ECG, EF according to echo-CG and radionuclide ventriculography, PP/EP M1/M2, T1/T2 according to echo-polycardiography and Doppler cardiography) was performed before the treatment and at ADM total dose 200-300 mg/m2 followed by measurements at each dose increase by 100 mg/m2. The findings showed no evidence of ADM-related cardiac damage up to ADM dose 900-1000 mg/m2 in the case of cardioxan protection, though there was a tendency to M1/M2 increase which needs further studies as it suggests worsening of left ventricular diastolic contractility.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Neoplasias de la Mama/tratamiento farmacológico , Fármacos Cardiovasculares/uso terapéutico , Corazón/efectos de los fármacos , Razoxano/uso terapéutico , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Neoplasias de la Mama/fisiopatología , Cardiomiopatías/inducido químicamente , Cardiomiopatías/diagnóstico , Cardiomiopatías/prevención & control , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Doxorrubicina/efectos adversos , Femenino , Fluorouracilo/administración & dosificación , Corazón/fisiopatología , Humanos , Persona de Mediana Edad , Contracción Miocárdica/efectos de los fármacos , Factores de TiempoRESUMEN
Cardiovascular and thromboembolic complications arising as a result of 1-16-year estrogen therapy were evaluated in 105 prostatic cancer patients. The incidence of the complications was higher in those who had pretreatment cardiological or vascular load. The latter caused death in half of the patients. Preventive and therapeutic measures to control the complications, prognosis signs are indicated.
Asunto(s)
Enfermedades Cardiovasculares/inducido químicamente , Congéneres del Estradiol/efectos adversos , Neoplasias de la Próstata/complicaciones , Tromboembolia/inducido químicamente , Anciano , Anciano de 80 o más Años , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/mortalidad , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Neoplasias de la Próstata/tratamiento farmacológico , Neoplasias de la Próstata/mortalidad , Neoplasias de la Próstata/patología , Tromboembolia/epidemiología , Tromboembolia/mortalidad , Factores de TiempoAsunto(s)
Antineoplásicos/efectos adversos , Corazón/efectos de los fármacos , Corazón/efectos de la radiación , Enfermedad de Hodgkin/terapia , Pericardio/efectos de los fármacos , Pericardio/efectos de la radiación , Radioterapia/efectos adversos , Animales , Ecocardiografía , Electrocardiografía , Cardiopatías/inducido químicamente , Cardiopatías/etiología , Enfermedad de Hodgkin/tratamiento farmacológico , Enfermedad de Hodgkin/radioterapia , Humanos , Conejos , Traumatismos por Radiación/etiología , Dosificación RadioterapéuticaAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Cardiomiopatía Dilatada/inducido químicamente , Linfoma no Hodgkin/tratamiento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Cardiomiopatía Dilatada/diagnóstico , Preescolar , Humanos , MasculinoRESUMEN
Thirty patients with Grade III breast cancer, a locally common form, were examined to compare the magnitude of the cardiotoxic effects displayed by the antitumor anthracyclic antibiotics adriamycin (15 patients) and pharmorubicin (15 patients). Clinical symptoms of cardiotoxicity developed in 13.3% of the pharmorubicin-treated and in 40% of the adriamycin-treated patients. Among the noninvasive techniques, electrocardiography turned out to be more informative, which enabled the signs of myocardial dystrophy and cardiac arrhythmias to be identified in 20 and 40% on pharmorubicin and adriamycin, respectively. Poly- and echocardiography proved to be less informative than it was shown by the data available in the literature, which is associated with the use of relatively small total doses of anthracycline in our investigations.
Asunto(s)
Arritmias Cardíacas/inducido químicamente , Neoplasias de la Mama/tratamiento farmacológico , Doxorrubicina/toxicidad , Epirrubicina/toxicidad , Insuficiencia Cardíaca/inducido químicamente , Adulto , Neoplasias de la Mama/fisiopatología , Ensayos Clínicos como Asunto , Relación Dosis-Respuesta a Droga , Doxorrubicina/administración & dosificación , Doxorrubicina/uso terapéutico , Epirrubicina/administración & dosificación , Epirrubicina/uso terapéutico , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Frecuencia Cardíaca/fisiología , Humanos , Persona de Mediana Edad , Contracción Miocárdica/efectos de los fármacos , Contracción Miocárdica/fisiologíaAsunto(s)
Neoplasias Cardíacas/secundario , Neoplasias Pulmonares/patología , Adulto , Humanos , MasculinoRESUMEN
Postradiation pericarditis was diagnosed in 11 of 52 patients treated for lymphogranulomatosis with radiation applied to enlarged mediastinal lymph nodes. The risk of postradiation pericarditis is greater in cases of high radiation doses (more than 45 Gy) and in patients with postradiation pneumonitis. Postradiation pericarditis can develop both during the exposure and long after radiation therapy; therefore long-term follow-up is required for these patients.
Asunto(s)
Radioisótopos de Cobalto/efectos adversos , Enfermedad de Hodgkin/radioterapia , Neoplasias del Mediastino/radioterapia , Pericarditis/etiología , Adulto , Diagnóstico Diferencial , Ecocardiografía , Electrocardiografía , Femenino , Enfermedad de Hodgkin/diagnóstico , Humanos , Masculino , Pericarditis/diagnósticoRESUMEN
Metastatic pericarditis was identified in 74 out of 240 cancer patients suffering from secondary tumor lesions in the heart (30.8%). It involved quick accumulation of exudate which led to grave heart failure due to cardiac tamponade development in 39%. Liquid in the heart sac was detected by X-rays in 20, ECG-39, and echocardiography--in 83% of patients. Application of echocardiography provides a means for ascertaining the extent of pericardial involvement and monitoring changes in tumor process occurring in the course of therapy.
Asunto(s)
Neoplasias Cardíacas/diagnóstico , Pericarditis/diagnóstico , Adolescente , Adulto , Anciano , Taponamiento Cardíaco/diagnóstico , Taponamiento Cardíaco/etiología , Femenino , Neoplasias Cardíacas/secundario , Humanos , Masculino , Métodos , Persona de Mediana Edad , Derrame Pericárdico/diagnóstico , Derrame Pericárdico/etiología , Pericarditis/etiologíaAsunto(s)
Neoplasias de la Mama/complicaciones , Enfermedad Coronaria/diagnóstico , Neoplasias Cardíacas/secundario , Neoplasias Gástricas/complicaciones , Adulto , Anciano , Enfermedad Coronaria/etiología , Diagnóstico Diferencial , Femenino , Neoplasias Cardíacas/diagnóstico , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Clinical and instrumental (ECG, PCG, ultrasonic cardiography and polycardiography) examination of cardiac activity in 98 breast cancer patients treated at the Center after Cooper established the cardiotoxic effect of 5-fluorouracil, vincristine, methotrexate, cyclophosphamide and corticosteroids. 46% of them suffered pain in the region of the heart, tachycardia, extrasystole, atrial flutter and deranged conduction function. Congestive heart failure was observed in 7% only. In 24%, myocardial lesions could be detected by instrumental means only. They were identified on the basis of an increase in terminal diastole and systole volume and mass of the myocardium matched by a decrease in stroke volume, PCG amplitude, % delta S and VCF. Cardiac disorders did not persist and were hardly detectable during medication course intervals or one-two months after treatment.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Neoplasias de la Mama/tratamiento farmacológico , Corazón/efectos de los fármacos , Adulto , Anciano , Ciclofosfamida/efectos adversos , Fluorouracilo/efectos adversos , Humanos , Masculino , Metotrexato/efectos adversos , Persona de Mediana Edad , Contracción Miocárdica/efectos de los fármacos , Prednisona/efectos adversos , Vincristina/efectos adversosAsunto(s)
Neoplasias Cardíacas/secundario , Enfermedad de Hodgkin , Pericardio , Sarcoma , Adulto , Femenino , Neoplasias Cardíacas/diagnóstico , HumanosAsunto(s)
Neoplasias Cardíacas/secundario , Neoplasias Pulmonares/diagnóstico , Neoplasias del Mediastino/diagnóstico , Pericardio/patología , Adulto , Anciano , Ecocardiografía , Electrocardiografía , Femenino , Neoplasias Cardíacas/diagnóstico , Humanos , Periodo Intraoperatorio , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , FonocardiografíaRESUMEN
Alternation of the heart was revealed in 18 of 74 patients with tumorous pericarditis with effusion (24%). It was found most frequently in patients with a drastically enlarged heart and a large amount of exudate in the pericardial cavity. An electrical, mechanical and mixed character of alternation was encountered in pericarditis with effusion. Electrical alternation was caused by increased mobility of the heart in the fluid, mechanical alternation (pulsus alternans) was caused by diminished contractile function of the myocardium. In certain cases alternation of the heart is a reversible process and may disappear under the effect of treatment including irradiation, chemotherapy and pericardiocentesis.
Asunto(s)
Contracción Miocárdica , Derrame Pericárdico/fisiología , Pericarditis/fisiopatología , Pulso Arterial , Sístole , Electrocardiografía , Femenino , Neoplasias Cardíacas/secundario , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The main electrocardiographic signs of metastasis and spread of malignant tumors to the heart in 123 patients were studied. The most reliable electrocardiographic criterion of tumor metastasis to the heart are signs of a macrofocal lesion with no dynamics of changes characteristic of ischemic heart disease. Spread of a tumor to the heart and micronodal metastasis are characterized by the appearance of signs of microfocal myocardial lesion on the ECG. Specific carcinomatous pericarditis has all the ECG signs that are typical of pericarditis of any other etiology. Electrical alternation in an oncological patient is a convincing sign of metastatic lesion of the heart.