RESUMEN
Purpose: The impact of gamma radiation on the reproductive biology of the spotted pod borer, Maruca vitrata (Fabr.) (Lepidoptera: Crambidae) was ascertained to explore the potential of the radio-genetic 'Inherited (F1) Sterility' technique (modified Sterile Insect technique) to control this serious pigeonpea pest in India.Materials and methods: Radio-biological investigations involved dose-response studies, at a range of 100-250 Gy, with respect to radiation induced adverse effects on reproductive behavior in substerilized parent (P1) moths, inheritance of sterility and associated metamorphic disruption in F1 progeny. The reproductive competence of P1 male moths and their F1 progeny was evaluated by ascertaining the survival, mating success, sperm transfer and amphimixis of gametes from irradiated male parents and their F1 progeny. Daily ovipositional and egg fertility profile were evaluated as crucial parameters for simulation modeling for this radio-genetic technique.Results: Radiation-induced check in insemination rate and sterility in P1 and F1 generation had a positive correlation with gamma dose. The metamorphic adverse effects in F1 progeny of substerilized P1 males were influenced by P1 irradiation. A higher dose of 200 Gy that resulted in 21.1% fertility in parent cross (P1âx Nâ) could form only 14.4% F1 adults that were all malformed. A gamma dose of 150 Gy (administered to P1 males) could be considered as a suitable dose for F1 sterility, that induced 57.4% control of reproduction in parent generation, followed by 72-85% control of reproduction in F1 progeny involved in three crosses -F1âxNâ, NâxF1â, F1âxF1â. Daily fertility profile of the eggs laid indicated a marked reduction on 4th day onwards during the ovipositional span in P1 and F1 generation. High degree of mating competitiveness value (CV) was noticed for 150 Gy irradiated male P1 moths (0.78-0.93), and their F1 male progeny (0.70-0.89), released in different sex ratios in the field cages having untreated moths. Reduced relative damage to the pigeon pea plants by the released F1 progeny in the field cages was observed in comparison to control.Conclusion: The present study indicated the potential use of a dose of 150 Gy to apply the 'F1 sterility' technique for parabiological suppression of the pigeon pea pod borer. The present findings and reproductive performance of the irradiated moths in F2 generation along with other compatible biorational pest control tactics (that are in progress), might help in formulating an effective integrated pest management module, including the F1 sterility technique as an integral component.
Asunto(s)
Infertilidad/etiología , Mariposas Nocturnas/efectos de la radiación , Control Biológico de Vectores/métodos , Animales , Cajanus , Femenino , Rayos gamma , Masculino , Metamorfosis Biológica/efectos de la radiación , Mariposas Nocturnas/fisiología , Dosis de Radiación , Radiobiología , Razón de MasculinidadRESUMEN
BACKGROUND: Management of early stages of osteonecrosis aims to prevent the collapse of the femoral head by attempts at restoring the vascularity of femoral head. Bone marrow-derived mononuclear cells with their angiogenic and osteogenic properties appear to have the potential to halt the disease process when injected intralesionally following core decompression. MATERIALS AND METHODS: Forty patients (60 hips) with stage I, II or III (ARCO system) osteonecrosis of femoral head were treated by either core decompression and isolated mononuclear cells (group A) or core decompression and unprocessed bone marrow injection (group B). The patients were followed up clinically and radiologically for a minimum of 2 years. The functional outcome was assessed in terms of Harris hip score, and disease progression was assessed radiologically by comparing the preoperative and follow-up MRI at the end of 2 years. RESULTS: On 2-year follow-up, there was considerable improvement in the hip function as measured by the Harris hip score in both the groups (p = 0.031). On MRI, there was a decrease in the size of the lesion in group A (p = 0.03). Three of 30 hips (10.0 %) in group B required total hip replacement. CONCLUSIONS: Implantation of autologous bone marrow stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome than bone marrow for early stage of avascular necrosis of femoral head.
Asunto(s)
Necrosis de la Cabeza Femoral/terapia , Trasplante de Células Madre Mesenquimatosas , Adulto , Trasplante de Médula Ósea , Separación Celular , Descompresión Quirúrgica , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Humanos , Inyecciones Intralesiones , Masculino , Células Madre Mesenquimatosas , Neovascularización Fisiológica , Osteogénesis , Recuperación de la Función , Índice de Severidad de la Enfermedad , Trasplante Autólogo , Resultado del TratamientoRESUMEN
PURPOSE: To report on 14 patients with osteoid osteomas treated by computed tomography-guided radiofrequency ablation. METHODS: Nine males and 5 females aged 13 to 45 (mean, 25) years with osteoid osteomas were included. The proximal tibia was the commonest site involved. A bipolar 18-gauge radiofrequency probe with a 9- mm active tip was used. A 4.5-mm hollow drill was introduced into the nidus. Energy application was started at 2 W and increased to a maximum of 5 W. Heat was applied for 4 to 6 minutes at 90 degrees Celsius. RESULTS: 12 (86%) of the 14 patients had prompt pain relief; the remaining 2 underwent a repeat ablation. After a mean follow-up period of 19 (range, 9-25) months, no patient had pain recurrence. CONCLUSION: Radiofrequency ablation is a minimally invasive and cost-effective treatment for osteoid osteomas.
Asunto(s)
Neoplasias Óseas/cirugía , Ablación por Catéter , Osteoma Osteoide/cirugía , Radiografía Intervencional , Tomografía Computarizada por Rayos X , Adolescente , Adulto , Neoplasias Óseas/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Osteoma Osteoide/diagnóstico por imagen , Estudios Prospectivos , Resultado del TratamientoRESUMEN
We describe a rare syndrome characterized by severe craniofacial hyperostosis, sclerosis, obliteration of paranasal sinuses and foramina of skull base, in a 10-year-old female child who presented with abnormal facial features and recurrent dacryocystitis due to narrowing of nasolacrimal duct.
Asunto(s)
Síndrome de Camurati-Engelmann/complicaciones , Anomalías Craneofaciales/complicaciones , Dacriocistitis/etiología , Síndrome de Camurati-Engelmann/diagnóstico por imagen , Niño , Anomalías Craneofaciales/diagnóstico por imagen , Femenino , Humanos , Conducto Nasolagrimal/diagnóstico por imagen , Recurrencia , Tomografía Computarizada por Rayos XRESUMEN
Progressive pseudorheumatoid chondrodysplasia is an autosomal recessively inherited skeletal dysplasia, characterised by platyspondyly and progressive arthropathy. We report a 26-year-old woman who presented with a history of waddling gait, progressive restriction of movements of several joints and swelling of interphalangeal joints since her late childhood. She was diagnosed to have progressive pseudorheumatoid chondrodysplasia associated with synovial osteochondromatosis.
Asunto(s)
Condromatosis Sinovial/genética , Osteocondrodisplasias/genética , Adulto , Condromatosis Sinovial/complicaciones , Condromatosis Sinovial/diagnóstico , Progresión de la Enfermedad , Femenino , Humanos , Osteocondrodisplasias/complicaciones , Osteocondrodisplasias/diagnósticoRESUMEN
Mucormycosis is an opportunistic fungal infection occurring most often in immunocompromised patients. The most common clinical presentation of infection with the fungus is rhinocerebral, followed by primary pulmonary, disseminated, gastrointestinal and cutaneous manifestations. Renal involvement in disseminated mucormycosis is well described, however, there are only few case reports describing the isolated renal mucormycosis in literature. We present an unusual case of renal mucormycosis in a patient of aplastic anaemia who presented with right flank pain and, on imaging, was found to have renal infarction and thrombosis of renal vessels. Histopathology revealed fungal hyphae infiltrating the entire kidney, renal vessels and perinephric space.
Asunto(s)
Anemia Aplásica/complicaciones , Infarto/microbiología , Enfermedades Renales/complicaciones , Riñón/irrigación sanguínea , Mucormicosis/complicaciones , Infecciones Oportunistas/complicaciones , Enfermedad Aguda , Adolescente , Resultado Fatal , Dolor en el Flanco/etiología , Humanos , Enfermedades Renales/diagnóstico , Masculino , Mucormicosis/diagnóstico , Obstrucción de la Arteria Renal/diagnóstico , Obstrucción de la Arteria Renal/microbiología , Venas Renales , Trombosis/diagnóstico , Trombosis/microbiología , Tomografía Computarizada por Rayos X , Ultrasonografía Doppler en Color , Trombosis de la Vena/diagnóstico , Trombosis de la Vena/microbiologíaRESUMEN
The association of linear scleroderma with melorheostosis is very rare. Until now, only a few cases have been reported in the English literature. We describe a case of melorheostosis of a rib associated with overlying skin changes.