RESUMEN
OBJECTIVE: This paper tests the extent to which differing trends in income, demographic change and the consequences of an earlier period of social, economic and political change might explain differences in the magnitude and trends in alcohol-related mortality between 1991 and 2011 in Scotland compared to England & Wales (E&W). STUDY DESIGN: Comparative time trend analyses and arithmetic modelling. METHODS: Three approaches were utilised to compare Scotland with E&W: 1. We modelled the impact of changes in income on alcohol-related deaths between 1991-2001 and 2001-2011 by applying plausible assumptions of the effect size through an arithmetic model. 2. We used contour plots, graphical exploration of age-period-cohort interactions and calculation of Intrinsic Estimator coefficients to investigate the effect of earlier exposure to social, economic and political adversity on alcohol-related mortality. 3. We recalculated the trends in alcohol-related deaths using the white population only to make a crude approximation of the maximal impact of changes in ethnic diversity. RESULTS: Real incomes increased during the 1990s but declined from around 2004 in the poorest 30% of the population of Great Britain. The decline in incomes for the poorest decile, the proportion of the population in the most deprived decile, and the inequality in alcohol-related deaths, were all greater in Scotland than in E&W. The model predicted less of the observed rise in Scotland (18% of the rise in men and 29% of the rise in women) than that in E&W (where 60% and 68% of the rise in men and women respectively was explained). One-third of the decline observed in alcohol-related mortality in Scottish men between 2001 and 2011 was predicted by the model, and the model was broadly consistent with the observed trends in E&W and amongst women in Scotland. An age-period interaction in alcohol-related mortality was evident for men and women during the 1990s and 2000s who were aged 40-70 years and who experienced rapidly increasing alcohol-related mortality rates. Ethnicity is unlikely to be important in explaining the trends or differences between Scotland and E&W. CONCLUSIONS: The decline in alcohol-related mortality in Scotland since the early 2000s and the differing trend to E&W were partly described by a model predicting the impact of declining incomes. Lagged effects from historical social, economic and political change remain plausible from the available data.
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Trastornos Relacionados con Alcohol/mortalidad , Humanos , Renta/tendencias , Mortalidad/tendencias , Política , Dinámica Poblacional/tendencias , Escocia/epidemiología , Factores SocioeconómicosRESUMEN
OBJECTIVE: To provide a basis for evaluating post-2007 alcohol policy in Scotland, this paper tests the extent to which pre-2007 policy, the alcohol market, culture or clinical changes might explain differences in the magnitude and trends in alcohol-related mortality outcomes in Scotland compared to England & Wales (E&W). STUDY DESIGN: Rapid literature reviews, descriptive analysis of routine data and narrative synthesis. METHODS: We assessed the impact of pre-2007 Scottish policy and policy in the comparison areas in relation to the literature on effective alcohol policy. Rapid literature reviews were conducted to assess cultural changes and the potential role of substitution effects between alcohol and illicit drugs. The availability of alcohol was assessed by examining the trends in the number of alcohol outlets over time. The impact of clinical changes was assessed in consultation with key informants. The impact of all the identified factors were then summarised and synthesised narratively. RESULTS: The companion paper showed that part of the rise and fall in alcohol-related mortality in Scotland, and part of the differing trend to E&W, were predicted by a model linking income trends and alcohol-related mortality. Lagged effects from historical deindustrialisation and socio-economic changes exposures also remain plausible from the available data. This paper shows that policy differences or changes prior to 2007 are unlikely to have been important in explaining the trends. There is some evidence that aspects of alcohol culture in Scotland may be different (more concentrated and home drinking) but it seems unlikely that this has been an important driver of the trends or the differences with E&W other than through interaction with changing incomes and lagged socio-economic effects. Substitution effects with illicit drugs and clinical changes are unlikely to have substantially changed alcohol-related harms: however, the increase in alcohol availability across the UK is likely to partly explain the rise in alcohol-related mortality during the 1990s. CONCLUSIONS: Future policy should ensure that alcohol affordability and availability, as well as socio-economic inequality, are reduced, in order to maintain downward trends in alcohol-related mortality in Scotland.
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Trastornos Relacionados con Alcohol/mortalidad , Alcoholes/provisión & distribución , Comercio/tendencias , Características Culturales , Humanos , Renta/tendencias , Políticas , Escocia/epidemiología , Normas SocialesRESUMEN
BACKGROUND: The Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) is an emergency department-based injury surveillance system that was devised in Canada and has been in operation since 1990. CHIRPP was imported to Glasgow's Royal Hospital for Sick Children at Yorkhill in 1996 and ran for 10 years. OBJECTIVE: To critically review CHIRPP at Yorkhill (Y-CHIRPP). The following two key questions were posed. (1) Did Y-CHIRPP fail, and, if so, why? (2) What generalisable lessons can be learned about injury surveillance? METHODS: A retrospective qualitative review of Y-CHIRPP was carried out. In gathering information, the aims were to: (a) describe the processes involved in running Y-CHIRPP; (b) identify changes made to that process over the 10 years; (c) determine the strengths and weaknesses of Y-CHIRPP. RESULTS: Taken together, and with reference to the WHO attributes of a good surveillance system, the findings suggest that Y-CHIRPP largely met the criteria of simplicity, flexibility, and acceptability. Criteria that were not, or only intermittently, met were reliability, utility, sustainability, and timeliness. CONCLUSIONS: Y-CHIRPP was, at best, a partial success. To maintain the viability of an injury surveillance system and to secure the long-term support of hospital staff, it is important that the system is perceived as an injury prevention service tool and not a research method. Experience with Y-CHIRPP suggests that injury surveillance requires three supporting posts: an emergency department staff member, a data analyst, and someone with responsibility for developing and/or lobbying for the implementation of preventive measures.
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Hospitales Pediátricos/organización & administración , Vigilancia de la Población/métodos , Heridas y Lesiones/epidemiología , Niño , Servicio de Urgencia en Hospital/organización & administración , Control de Formularios y Registros/normas , Investigación sobre Servicios de Salud/métodos , Humanos , Personal de Hospital/normas , Evaluación de Programas y Proyectos de Salud , Estudios Retrospectivos , Escocia/epidemiología , Heridas y Lesiones/prevención & controlRESUMEN
Transfer of CD45RB(high) CD4+ T cells to immune-deficient mice in the absence of regulatory T cells leads to a Th1-mediated colitis. In this study, we show that intestinal inflammation is characterized by a 15-fold increase in the number of CD134L+ (OX40L+)-activated DC in the mesenteric lymph nodes (MLNs) compared with BALB/c mice. This was important functionally, as administration of an anti-CD134L mAb inhibited the proliferation of T cells in the MLNs as well as their expression of the gut-homing integrin alpha(4)beta(7). Most importantly, the anti-CD134L mAb completely blocked development of colitis. Surprisingly, CD134L was found to be expressed by a proportion of dendritic cells (DC) in the MLNs of unreconstituted SCID mice, suggesting that CD134L can be induced on DC in the absence of T cell-derived signals. These results indicate that some DC in the MLNs of SCID mice express an activated phenotype and that CD134L expression by these cells is involved in the development of colitis induced by T cell transfer. Accumulation of CD134L+ DC was inhibited by cotransfer of regulatory T cells, suggesting that inhibition of the accumulation of activated DC is one mechanism by which these cells prevent immune pathology.