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1.
Korean J Neurotrauma ; 13(1): 24-28, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-28512614

RESUMEN

OBJECTIVE: Head injury is a leading cause of death and disability in subjects who suffer a traumatic accident. Contralateral hematomas after surgery for traumatic brain injury are rare. However, an unrecognized, these hematomas can cause devastating results. We presented our experience of these patients and discussed diagnosis and management. METHODS: This study included 12 traumatic patients with acute traumatic brain injury who developed delayed contralateral hematoma after evacuation of an acute hematoma. Clinical and radiographic data was obtained through review of medical records and radiographs retrospectively. RESULTS: Ten males and two females were included in the study. Ten (83.3%) patients had severe head injury (Glasgow Coma Scale [GCS] score <8). Intraoperative brain swelling during removal of the traumatic subdural hematoma was noted in 10 (83.3%) patients. A skull fracture on the side contralateral to the acute hematoma was noted on computed tomography (CT) scans of nine (75%) patients. Three (33.3%) patients with severe head injury (GCS <8) died. Only (10%) one patient with a severe head injury had less severe disability. CONCLUSION: A postoperative CT scan is essential in patients with acute traumatic brain injury and a contralateral skull fracture or a low GCS score. Our results indicated that it is very important to evaluate this rare but potentially devastating complication.

2.
Korean J Neurotrauma ; 10(1): 26-30, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-27169029

RESUMEN

OBJECTIVE: The intracranial pathologies after head trauma should be usually progressed. It is clearly visualized in the non-invasive brain CT. The invasive monitor such as intracranial pressure (ICP) monitoring may be accompanied with the complications. This study aims whether the patients with severe head injury could be managed with serial CT scans. METHODS: The medical records of 113 patients with severe head injury in the prospectively enrolled trauma bank were retrospectively analyzed. After the emergency care, all the patients were admitted to the intensive care unit for the aggressive medical managements. Repeat brain CT scans were routinely taken at 6 hours and 48 hours after the trauma. ICP monitoring was restrictively applied for the uncertain intracranial pressure based on the CT. The surgical intervention and the mortality rate were analyzed. RESULTS: Immediate surgical intervention after the initial CT scan was done in 47 patients. Among the initially non-surgical patients, 59 patients were managed with the serial CT scans and 7 with the ICP monitoring. Surgical interventions underwent eventually for 10 patients in the initially non-surgical patients; 1 in the ICP monitoring and 9 in the serial CT. The mortality rate was 23.7% in the serial brain CT and 28.6% in the ICP monitoring. There was no statistical difference between two groups in the aspect of mortality (p=0.33). CONCLUSION: Serial CT scans in time could be a good way to monitor the intracranial progression in the severe head injury and reduce the implantation of an invasive ICP probe.

3.
Korean J Spine ; 10(4): 242-5, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24891856

RESUMEN

Although juxtafacet cysts of the lumbar spine are being reported with increasing frequency, hemorrhage from a ganglion cyst is rare, and the pathophysiologic mechanism of the hemorrhage from the cyst is still unclear. A 75-year-old male presented with sudden radicular leg pain caused by hemorrhage from the ganglion cyst. Computed tomography revealed bony erosion of vertebral body and multiple punched-out lesions on facets. Magnetic resonance imaging showed the neural structure was compressed by a sharply delineating mass. Capsule and old hematoma with elastic consistency that extended to the epidural space were removed through a paramedian transforaminal approach, which led to the resolution of the patient's symptoms. Histopathologically, chronic inflammation with neovascularization and myxoid degeneration were present in the capsule. Alcian blue staining demonstrated the mixture of mucin and hematoma. The probable pathogenesis of hemorrhage from the cyst was discussed from the unique histopathological findings of surgical specimen.

4.
J Korean Neurosurg Soc ; 52(4): 384-90, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23133729

RESUMEN

OBJECTIVE: The objective of this study was to investigate the morphologic characteristics between the vertebral body and the regions of the cervical and thoracic spinal cords where each rootlets branch out. METHODS: Sixteen adult cadavers (12 males and 4 females) with a mean age of 57.9 (range of 33 to 70 years old) were used in this study. The anatomical relationship between the exit points of the nerve roots from the posterior root entry zone at each spinal cord segment and their corresponding relevant vertebral bodies were also analyzed. RESULTS: Vertical span of the posterior root entry zone between the upper and lower rootlet originating from each spinal segment ranged from 10-12 mm. The lengths of the rootlets from their point of origin at the spinal cord to their entrance into the intervertebral foramen were 5.9 mm at the third cervical nerve root and increased to 14.5 mm at the eighth cervical nerve root. At the lower segments of the nerve roots (T3 to T12), the posterior root entry zone of the relevant nerve roots had a corresponding anatomical relationship with the vertebral body that is two segments above. The posterior root entry zones of the sixth (94%) and seventh (81%) cervical nerve roots were located at a vertebral body a segment above from relevant segment. CONCLUSION: Through these investigations, a more accurate diagnosis, the establishment of a better therapeutic plan, and a decrease in surgical complications can be expected when pathologic lesions occur in the spinal cord or vertebral body.

5.
J Korean Neurosurg Soc ; 52(2): 133-7, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23091672

RESUMEN

OBJECTIVE: Twist-drill craniostomy (TDC) with closed-system drainage and burr-hole drainage (BHD) with a closed system are effective treatment options for chronic subdural hematoma (CSDH). The aim of this study was to analyze clinical data and surgical results from symptomatic CSDH patients who underwent TDC with closed-system drainage at the pre-coronal point (PCP). METHODS: We analyzed data for 134 symptomatic CSDH patients who underwent TDC at the PCP with closed-system drainage. We defined the PCP for TDC to be 1 cm anterior to the coronal suture at the level of superior temporal line. TDC at the PCP with closed-system drainage was selected in patients with CSDH that extended beyond the coronal suture, confirmed by preoperative CT scans. Medical records, radiological findings, and clinical performance were reviewed retrospectively. RESULTS: Of the 134 CSDH patients, 114 (85.1%) showed improved clinical performance and imaging findings after surgery. Catheter failures were seen in two cases (1.4%); the catheters were inserted in the epidural space. Recurrent cases were seen in eight patients (5.6%), and they were improved with a second BHD with a closed-system operation. CONCLUSION: TDC at the PCP with closed-system drainage is safe and effective for patients with symptomatic CSDH whose hematomas extend beyond the coronal suture.

6.
World Neurosurg ; 77(2): 391-3, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22099559

RESUMEN

OBJECTIVE: To assess the authors' experience of wound management following scalp mass surgery after introducing a policy of leaving hair unshaved and allowing patients to use shampoo. METHODS: The authors retrospectively reviewed 93 patients who underwent outpatient-based excision of a scalp or skull mass. Surgical complications, mass depth, and maximal mass size were analyzed. All of the surgeries were performed without shaving around the lesion; the hair was simply parted along the proposed incision, and the parting was maintained using adhesive plasters. Routine antiseptic scalp preparations, skin closure with staples after mass excision, and topical ointment on the day following surgery were used, and use of shampoo was allowed. The staples were removed on postoperative days 7-10. RESULTS: The masses were located in the skin (23 cases), subcutaneously (64 cases), and subgaleally (6 cases). All patients except one had satisfactory wound healing. No infections occurred. CONCLUSIONS: Leaving hair unshaved and allowing patients to use shampoo can be applied in wound management after scalp mass surgery.


Asunto(s)
Procedimientos Quirúrgicos Ambulatorios/métodos , Remoción del Cabello/efectos adversos , Cuero Cabelludo/cirugía , Adolescente , Adulto , Anciano , Antiinfecciosos Locales/uso terapéutico , Profilaxis Antibiótica , Niño , Preescolar , Femenino , Cabello/fisiología , Humanos , Lactante , Masculino , Persona de Mediana Edad , Pomadas , Estudios Retrospectivos , Enfermedades de la Piel/cirugía , Neoplasias Cutáneas/cirugía , Jabones , Cicatrización de Heridas , Adulto Joven
7.
J Korean Neurosurg Soc ; 50(3): 195-200, 2011 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-22102948

RESUMEN

OBJECTIVE: To present the profiles of spinal cord tumors that can be removed through a unilateral hemilaminectomy and to demonstrate its usefulness for benign spinal cord tumors that significantly occupy the spinal canal. METHODS: From June 2004 to October 2010, 25 spinal cord tumors were approached with unilateral hemilaminectomy. We calculated the cross-sectional occupying ratio (CSOR) of tumor to spinal canal before and after the operations. RESULTS: The locations of the tumors were intradural extramedullary in 20 cases, extradural in 2, and intramedullary in 3. The levels of the tumors were lumbar in 12, thoracic 9, and cervical 4. In all cases, the tumor was removed grossly and totally without damaging spinal cord or roots. The mean height and width of the lesions we195re 17.64 mm (3-47.5) and 12.62 mm (4-32.7), respectively. The mean CSOR was 69.40% (range, 27.8-96.9%). Postoperative neurological status showed improvement in all patients except one whose neurologic deficit remained unchanged. Postoperative spinal stability was preserved during the follow-up period (mean, 21.5 months) in all cases. Tumor recurrence did not develop during the follow-up period. CONCLUSION: Unilateral hemilaminectomy combined with microsurgical technique provides sufficient space for the removal of diverse spinal cord tumors. The basic profiles of the spinal cord tumors which can be removed through the unilateral hemilaminectomy demonstrate its role for the surgery of the benign spinal cord tumors in various sizes.

8.
Radiology ; 259(3): 885-93, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21386053

RESUMEN

PURPOSE: To prospectively compare the effectiveness of iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) T2-weighted and contrast material-enhanced T1-weighted magnetic resonance (MR) imaging with that of a conventional MR imaging protocol in minimizing metallic artifacts in phantoms and in patients with metallic hardware after spinal surgery. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained for this study. Coronal T1- and T2-weighted MR images of six titanium alloy pedicle screws in an oil bath containing tubes filled with diluted gadolinium contrast medium were obtained with frequency-selective fat saturation (FSFS) and IDEAL. Axial T2-weighted and contrast-enhanced T1-weighted MR imaging of the spine was performed with FSFS and IDEAL at 22 lumbar levels in 19 patients. Two musculoskeletal radiologists qualitatively analyzed the images in terms of the visualization of paravertebral muscle and the spinal canal region, uniformity of fat saturation, and noise. The paired images were rated by using a five-point scale. For the quantitative study with phantoms, the short- and long-axis lengths of metallic artifacts were determined on signal intensity profiles. RESULTS: In the phantom study, metallic artifact size was markedly decreased in the IDEAL T2-weighted and contrast-enhanced T1-weighted images (P < .001). In the clinical study, IDEAL T2-weighted and contrast-enhanced T1-weighted images enabled significantly improved visualization of the dural sac (P < .001), spinal muscles (P < .05), uniformity of fat saturation (P < .001), and noise (P < .05). CONCLUSION: IDEAL T2-weighted and contrast-enhanced T1-weighted MR imaging examinations effectively reduce the degree of tissue-obscuring artifacts produced by spinal fixation hardware and improve image quality compared with FSFS T2-weighted and contrast-enhanced T1-weighted MR imaging. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101856/-/DC1.


Asunto(s)
Artefactos , Aumento de la Imagen/métodos , Fijadores Internos , Imagen por Resonancia Magnética/métodos , Columna Vertebral/cirugía , Adulto , Anciano , Medios de Contraste , Femenino , Gadolinio , Humanos , Análisis de los Mínimos Cuadrados , Masculino , Persona de Mediana Edad , Fantasmas de Imagen , Estudios Prospectivos , Titanio
9.
J Korean Med Sci ; 25(4): 647-50, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20358015

RESUMEN

Shunt malfunctions that require surgical intervention during pregnancy and the postpartum period are rare. Furthermore, no study has reported on an acute shunt malfunction immediately after cesarean section. Here, we describe the case of a 32-yr-old woman who became drowsy 12 hr after cesarean section delivery of her second child. She had a ventriculoperitoneal shunt placed to treat hydrocephalus associated with meningitis at 26 yr of age. Marked ventriculomegaly was seen on brain computed tomography and her consciousness recovered temporarily after aspirating cerebrospinal fluid from the flushing device. At surgery, the distal catheter tip was plugged by a blood clot. We believe that the blood spilled over during the cesarean section. The clogged catheter end was simply cut off and the remaining catheter was repositioned in the peritoneal cavity. Her consciousness recovered fully.


Asunto(s)
Cesárea , Falla de Equipo , Derivación Ventriculoperitoneal , Adulto , Femenino , Humanos , Hidrocefalia/etiología , Hidrocefalia/cirugía , Meningitis/complicaciones , Embarazo , Derivación Ventriculoperitoneal/efectos adversos , Derivación Ventriculoperitoneal/instrumentación
10.
J Korean Med Sci ; 25(3): 505-8, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20191058

RESUMEN

The intravenous administration of gadopentetate dimeglumine (GD) is relatively safe and rarely causes systemic toxicity in the course of routine imaging studies. However, the general safety of intrathecal GD has not been established. We report a very rare case of an overdose intrathecal GD injection presenting with neurotoxic manifestations, including a decreased level of consciousness, global aphasia, rigidity, and visual disturbance.


Asunto(s)
Medios de Contraste , Gadolinio DTPA , Inyecciones Espinales , Síndromes de Neurotoxicidad , Adulto , Afasia/etiología , Afasia/patología , Afasia/fisiopatología , Encéfalo/efectos de los fármacos , Encéfalo/patología , Medios de Contraste/administración & dosificación , Medios de Contraste/toxicidad , Gadolinio DTPA/administración & dosificación , Gadolinio DTPA/toxicidad , Humanos , Masculino , Rigidez Muscular/etiología , Rigidez Muscular/patología , Rigidez Muscular/fisiopatología , Síndromes de Neurotoxicidad/etiología , Síndromes de Neurotoxicidad/patología , Síndromes de Neurotoxicidad/fisiopatología , Tomografía Computarizada por Rayos X , Trastornos de la Visión/etiología , Trastornos de la Visión/patología
11.
J Korean Neurosurg Soc ; 46(4): 409-12, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19893735

RESUMEN

There are several mechanisms for the dissemination of lipid material from a mature teratoma into the subarachnoid space or ventricles, including iatrogenic or traumatic rupture, but spontaneous rupture of a mature teratoma is rare. We report the spontaneous rupture of a spinal mature teratoma into the subarachnoid space and ventricles. However, at surgery, there was no definite evidence of rupture into the perimedullary cerebrospinal fluid. We postulate that the central canal could be a migration pathway for ruptured material into the brain.

12.
J Korean Neurosurg Soc ; 46(3): 269-72, 2009 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19844631

RESUMEN

A rare case of hemifacial spasm caused by an ipsilateral tentorial meningioma is described. Magnetic resonance imaging showed a huge tumor in the right cerebellar hemisphere, distant to the cerebello-pontine cistern. The facial-vestibulocochlear nerve complex was stretched by the shift of the brainstem and the right cerebello-pontine cistern was effaced. After removing the tumor, the hemifacial spasm resolved completely. We review our case with the pertinent literature regarding the etiological mechanism.

13.
J Neurosurg ; 110(6): 1265-70, 2009 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19099378

RESUMEN

OBJECT: Twist-drill craniostomy (TDC) with closed-system drainage is an effective treatment option for chronic subdural hematoma (CSDH). Because the entry point for TDC has not been described in a definitive area, the aim of this study was to define the optimal twist-drill entry point for CSDH. METHODS: The authors selected 40 random cases involving selective catheter angiography of the external carotid artery, regardless of study purpose, to evaluate the course of the middle meningeal artery. Furthermore, 50 skull radiographs were reviewed to assess the relation of the vascular groove to the coronal suture. On the basis of the radiological anatomical study, the authors propose that the normal TDC entry point should be 1 cm anterior to the coronal suture at the level of the superior temporal line (STL). Thirty patients with symptomatic CSDH were treated using TDC with closed-system drainage at the proposed entry point. The thicknesses of the hematoma and the skull were measured at the proposed entry point. The congruence between the proposed entry point and postoperative craniostomy was estimated and complications were evaluated. RESULTS: In the radiological study, all the branches of the middle meningeal artery ran posterior to the coronal suture and the vascular grooves were also located posterior to the coronal suture at the level of the STL. The average distance of the vascular grooves was 8.0 +/-5.8 mm. Thirty-five procedures were performed. The coronal suture and the STL could be identified clearly on brain CT scans. The mean thickness of the skull and the CSDH at the proposed point was 8 mm (range 5-13 mm) and 20 mm (range 10-28 mm), respectively. All the TDCs except 1 were congruent with the preoperative brain CT scans. One CSDH recurred 1 month after the first operation and was revised using the same procedure. No other complications occurred. CONCLUSIONS: One centimeter anterior to the coronal suture at the level of the STL is suitable as the normal entry point of the TDC for symptomatic CSDH. The thickness of the CSDH can be measured at this point on a preoperative brain CT scan. Furthermore, the entry point on the scalp can be accurately estimated using surface landmarks.


Asunto(s)
Craneotomía/métodos , Drenaje , Hematoma Subdural Crónico/terapia , Ventriculostomía , Anciano , Anciano de 80 o más Años , Cateterismo , Estudios de Cohortes , Suturas Craneales/diagnóstico por imagen , Femenino , Hematoma Subdural Crónico/diagnóstico por imagen , Hematoma Subdural Crónico/etiología , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Estudios Retrospectivos , Resultado del Tratamiento
14.
J Korean Neurosurg Soc ; 43(6): 300-3, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19096636

RESUMEN

Shunt infections are a common complication of ventriculoperitoneal (VP) shunts, but the formation of a brain abscess related to a shunt system is very rare. A 44-year-old woman had a VP shunt inserted for hydrocephalus secondary to a subarachnoid hemorrhage. She suffered an episode of meningitis and sepsis 8 months after the shunt operation. After recovering from the meningitis, she complained of a loss of cognitive function. An enhancing mass was found in the frontal lobe, around the frontal horn of the lateral ventricle, and the ventricular catheter was embedded inside the mass. The ventricular catheter and cerebral abscess were removed using neuroendoscopy. We present an interesting case of a shunt-related brain abscess which illustrates the usefulness of neuroendoscopy.

15.
J Korean Neurosurg Soc ; 44(3): 109-15, 2008 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19096659

RESUMEN

When a tear occurs in one of the major cervicocerebral arteries and allows blood to enter the wall of the artery and split its layers, the result is either stenosis or aneurysmal dilatation of the vessel. Vertebral artery dissection (VAD) is an infrequent occurrence but is a leading cause of stroke in young and otherwise healthy patients. This article discusses recent developments in understanding of the epidemiology and pathogenesis of VAD and the various clinical manifestations, methods of diagnosis, and approaches to treatment.

16.
J Korean Neurosurg Soc ; 44(2): 78-83, 2008 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19096697

RESUMEN

OBJECTIVE: To understand the anatomic characteristics of the aortic arch (AA) and its major branches to build a foundation toward performing endovascular surgery safely. METHODS: A total of 25 formalin fixed Korean adult cadavers were used. The authors investigated : anatomical variations of the AA and its major branches; curvature of the AA; distance from the mid-vertebrae line to the origin of the major branches; distances from the origin of the major branches of AA to the origin of its distal branches; and the angle of the three major branches, the brachiocephalic trunk (BCT), the left common carotid artery (LCCA) and the left subclavian artery (LSCA) arising from AA. RESULTS: The three major branches directly originated from AA in 21 (84%) of the cadavers. In two (8%) of remaining four cadavers, orifice of LCCA was slightly above the stem of BCT. In remaining two (8%) cadavers, the left vertebral artery (LVA) was directly originated from AA. Average angle of AA curvature to the coronal plane was 62.2 degrees. BCT originated 0.92 mm on the right of the mid-vertebrae line. LCCA and LSCA originated from 12.3 mm and 22.8 mm on the left of the mid-vertebrae line. Mean distance from the origin of the BCT to the origin of the RCCA was 32.5 mm. Mean distance from the origin of the LSCA to the origin of the LVA was 33.8 mm. Average angles at which the major branches arise from the AA were 65.3, 46.9 and 63.8 degrees. CONCLUSION: This study may provides a basic anatomical information to catheterize AA and its branches for safely performing endovascular surgery.

17.
J Korean Neurosurg Soc ; 42(6): 484-6, 2007 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19096595

RESUMEN

The authors describe a case of pseudoaneurysm arising from internal iliac artery presented with radiculopathy mimicking the symptoms of lumbar disc disease or spinal cord tumor. Among the several preoperative evaluation including CT, MRI, electrophysiologic study and ultrasonography, important diagnostic clue was obtained by ultrasonographic findings of turbulence flow at the core of partially enhanced mass in the pelvic cavity. The patient was managed with endovascular coil embolization successfully. The current case makes us remind that assessment of neurological symptoms on lower extremity should include consideration of extraspinal cause in pelvis.

18.
Artículo en Inglés | WPRIM (Pacífico Occidental) | ID: wpr-157547

RESUMEN

A 18-month-old girl was seen because of an yellowish brown papular eruptions on the face, earlobes and neck of one year duration. A skin biopsy specimen revealed circumscribed cellular infiltrates composed of predorninantly pleornorphic histiocytes. Electron microscopy of biopsy material disclosed numerous worm like particles and coated vescles in limited area of the cell cytoplasm, consistent with the findinga described in benign cephalic histiocytosis. After six months of her first visit, the individual papules became flattened.


Asunto(s)
Femenino , Humanos , Lactante , Biopsia , Vesículas Cubiertas , Citoplasma , Histiocitos , Histiocitosis , Microscopía Electrónica , Cuello , Piel
19.
Artículo en Coreano | WPRIM (Pacífico Occidental) | ID: wpr-43405

RESUMEN

On a total 375 sera with reactive results on VDRL and/or FTA-ABS test(s), derived from severance Hospital, qualitative and quantitative TPHA tests were carried out. The objectives of the present study were to compare the result of VDRL, FTA-ABS and TPHA teats in different syphilis stages, and to as sess the suitability of the TPHA test as a screening test for syphilis. The results are summarized as follows: 1. The sensitivity of VDRL test was poor compared with TPHA and FTA-ABS tests except in secondary syphilis. 2. The FTA-ABS test(10Qp,) was more sensitive than the TPHA test(86g) in primary syphilis, but it is time consuming and costly. 3 The TPHA titers were relatively low in primary syphilis. 4, Below 1: 32Q in TPHA titer, the percentage of sera from patients tested over 1 year(64%) after the completion of treatment was higher than within 1 year(41%). The TPHA test showed 77%. agreement with VDRL test and 89% agreement with FTA-ABS test. The VDRL test is easy to perform and economic, but it showed poor effeetiveness as screening test for the detection of syphilis. On the other hand the TPHA test had a wide spectrum of reactivity in different stages of syphilis and was easy to perform. So on the basis of the results presented, we concluded that the TPHA test provides a very effective screen for syphilis.


Asunto(s)
Humanos , Prueba de Absorción de Anticuerpos Fluorescentes de Treponema , Mano , Pruebas de Hemaglutinación , Hemaglutinación , Tamizaje Masivo , Pruebas Serológicas , Sífilis , Treponema pallidum , Treponema
20.
Artículo en Coreano | WPRIM (Pacífico Occidental) | ID: wpr-124092

RESUMEN

We have experienced a case of neurofibromatosis with unusual giant pigmentation, which presents itself as a 28 cm x 40 cm sized, serrated bordered light brownish patch speckled with small dark hyperpigmented macules on his back. Histopathologic examinations of light brown patch and speckles showed only an increase in basal melanin pigmentation.


Asunto(s)
Melaninas , Neurofibromatosis , Pigmentación
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