Asunto(s)
Ortodoncia , Administración de la Práctica Odontológica , Acreditación , Adolescente , Adulto , Niño , Personal de Odontología , Competencia Económica , Educación en Odontología , Predicción , Historia del Siglo XX , Humanos , Comercialización de los Servicios de Salud , Ortodoncia/educación , Ortodoncia/historia , Ortodoncia/tendencias , PacientesRESUMEN
A healthy normally intelligent man and his two daughters who had mild developmental delay and different malformations were determined to have an acrocentric supernumerary microchromosome (MC). The father and both daughters were noted to be mosaic for the MC, perhaps suggesting mitotic instability of the MC cell line with loss over time. The MC was negative staining on G-banding and showed absence of centromeric heterochromatin on C-banding. A centromere was identified with silver staining; no NORs were identified. The MC approximated the size of the short arm of the Y chromosome and showed cytologic behavior similar to that of a Y chromosome. H-Y antigen and Y-DNA gene probe studies failed to confirm a Yp origin.
Asunto(s)
Anomalías Múltiples/genética , Aberraciones Cromosómicas , Cromosomas Humanos/ultraestructura , Mosaicismo , Adulto , Coartación Aórtica/genética , Preescolar , Discapacidades del Desarrollo/genética , Femenino , Marcadores Genéticos , Humanos , Lactante , Masculino , Linaje , Pulgar/anomalías , Cromosoma Y/ultraestructuraRESUMEN
The action of ginseng saponins on cell numbers, glucose uptake and lactate production and the activities of specific enzymes associated with glucose oxidation, was tested using a human diploid fibroblast strain. No augmentation of cell numbers was observed. There was a significant increase in the level of cellular lactate levels and in the specific activities of enzymes associated with an anaerobic shift in metabolism. The possible relationship between these findings and the reputed efficacy of ginseng administration in the elderly is discussed.