Búsqueda | Portal Regional de la BVS

Mostrar: 20 | 50 | 100

Resultados 1 - 1 de 1

Filtrar

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: an inhibitor of AP-1 and NF-kappaB mediated gene expression.

Palanki, Moorthy S S; Gayo-Fung, Leah M; Shevlin, Graziella I; Erdman, Paul; Sato, Mark; Goldman, Mark; Ransone, Lynn J; Spooner, Cheryl.

Bioorg Med Chem Lett ; 12(18): 2573-7, 2002 Sep 16.

Artículo en Inglés | MEDLINE | ID: mdl-12182863

RESUMEN

Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-kappaB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)-pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.

Asunto(s)

Regulación de la Expresión Génica/fisiología , FN-kappa B/antagonistas & inhibidores , Pirimidinas/farmacología , Pirroles/farmacología , Factor de Transcripción AP-1/antagonistas & inhibidores , Humanos , Células Jurkat , FN-kappa B/fisiología , Pirimidinas/química , Pirroles/química , Relación Estructura-Actividad , Factor de Transcripción AP-1/fisiología

Ver mas detalles

ENVIAR RESULTADO:

Exportar

Imprimir

RSS

XML

RESUMEN

Asunto(s)

ENVIAR RESULTADO:

SELECCIÓN DE REFERENCIAS

DETALLE DE LA BÚSQUEDA