Asunto(s)
Factor Natriurético Atrial/sangre , Hipertensión/sangre , Animales , Biomarcadores/sangre , HumanosRESUMEN
With the view to study state of antioxidant protection and membrane lipid peroxidation (LPO) in hypertonic disease (HD) 200 patients with HD of I and II stage (WHO classification) were examined. Structural and functional state of myocardium was assessed echocardiographically. Enzymatic and non-enzymatic LPO, catalase and superoxide-dismutase activity were analyzed in erythrocytes. Destabilization of cell membranes due to LPO activation and alteration of antioxidant potential established in patients with HD was paralleled by the degree of left ventricle hypertrophy.
Asunto(s)
Antioxidantes , Membrana Eritrocítica/metabolismo , Hipertensión/sangre , Peroxidación de Lípido , Lípidos de la Membrana/sangre , Catalasa/sangre , Permeabilidad de la Membrana Celular , Femenino , Humanos , Hipertrofia Ventricular Izquierda/sangre , Masculino , Persona de Mediana Edad , Superóxido Dismutasa/sangreRESUMEN
The plasma level of atrial natriuretic factor and its relation to intracardiac and systemic hemodynamic parameters were examined in patients with coronary heart, rheumatic and mitral valvular diseases, neurocirculatory dystonia which were complicated by atrial fibrillation. The concentration of atrial natriuretic factor was found to vary with the left ventricular myocardial mass, left atrial contractility, antiarrhythmic therapy intensity and efficacy.
Asunto(s)
Fibrilación Atrial/sangre , Factor Natriurético Atrial/sangre , Ventrículos Cardíacos/patología , Contracción Miocárdica/fisiología , Adulto , Anciano , Fibrilación Atrial/etiología , Fibrilación Atrial/patología , Fibrilación Atrial/fisiopatología , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The time course of structural and functional parameters using echocardiography and the level of atrial natriuretic factor (ANF) employing immunoradiometric assay were examined in 37 patients with essential hypertension taking a 3-week therapy with nifedipine (corinfar) in doses individually chosen. The changes in the structural and functional parameters of the hypertensive heart were found to be associated with its endocrine function. A course therapy of patients with essential hypertension with nifedipine in individually based doses caused a significant rise in plasma ANF levels, a normalization of cardiac compensatory mechanism function. The findings may be a basis for studying the new mechanisms of calcium antagonist action.
Asunto(s)
Factor Natriurético Atrial/sangre , Corazón/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Nifedipino/uso terapéutico , Adulto , Anciano , Ecocardiografía , Femenino , Corazón/fisiopatología , Humanos , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Nifedipino/farmacologíaRESUMEN
As a result of clinico-physiological examinations 643 patients suffering from cerebral atherosclerosis were divided into 3 groups by the severity of atherosclerosis of the cerebral vessels. These patients also exhibited atherosclerosis of the coronary and retinal vessels. Mathematical methods have been used to study the relationship and severity of atherosclerosis of the cerebral, coronary and retinal vessels. The findings obtained indicate that despite a systemic nature of the atherosclerotic process the involvement of various vascular areas is individual and asynchronous. With the development of cerebral atherosclerosis its correlation with atherosclerosis of other localizations becomes closer.