1.
Effects of diltiazem on calcium ion translocation: a study on isolated frog rectus abdominis muscle.
Indian J Physiol Pharmacol
; 39(1): 83-5, 1995 Jan.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7705879
RESUMEN
Diltiazem, a calcium channel blocker was studied to observe its effects on the acetylcholine contractile responses of isolated frog rectus abdominis muscle. This response was modified in a dual manner i.e., initial potentiation, followed by inhibition. Diltiazem may not have anticholinesterase like mechanism, as it potentiated the responses to both acetylcholine and succinylcholine. Rectus muscle preparation, incubated in calcium free frog Ringer, showed dose dependent inhibition of acetylcholine contractile responses by diltiazem. The study suggests that diltiazem inhibits calcium ion influx across receptor operated calcium channels and may also inhibit calcium ion release from intracellular structures.
Asunto(s)
Calcio/metabolismo , Diltiazem/farmacología , Recto del Abdomen/efectos de los fármacos , Acetilcolina/antagonistas & inhibidores , Acetilcolina/farmacología , Animales , Anuros , Canales de Calcio/efectos de los fármacos , Canales de Calcio/fisiología , Relación Dosis-Respuesta a Droga , Sinergismo Farmacológico , Técnicas In Vitro , Contracción Muscular/efectos de los fármacos , Recto del Abdomen/metabolismo , Succinilcolina/antagonistas & inhibidores , Succinilcolina/farmacología
2.
Indian J Physiol Pharmacol
; 33(3): 199-200, 1989.
Artículo
en Inglés
| MEDLINE
| ID: mdl-2592048
3.
Indian J Physiol Pharmacol
; 18(4): 330-3, 1974.
Artículo
en Inglés
| MEDLINE
| ID: mdl-4466791