RESUMEN
Clinical and laboratory evaluation of the preparation Acipol in 45 children greatly susceptible to acute respiratory virus infections (ARVI) was carried out. Simultaneously with the clinical analysis, the study of the microflora of the mucous membranes of the upper respiratory tracts and intestine, as well as the levels of secretory IgA in saliva and coprofiltrates before and after treatment, was made. The inclusion of Acipol into the therapy of ARVI patients facilitated their clinical convalescence, uncomplicated course of the disease, correction of disturbances in the biocenosis of the upper respiratory tracts and increased infectious resistance.
Asunto(s)
Antivirales/uso terapéutico , Membrana Mucosa/virología , Infecciones del Sistema Respiratorio/virología , Enfermedad Aguda , Adolescente , Niño , Preescolar , Convalecencia , Sistema Digestivo/virología , Evaluación de Medicamentos , Humanos , Inmunoglobulina A/inmunología , Lactante , Mucosa Nasal/virología , Infecciones del Sistema Respiratorio/tratamiento farmacológico , Saliva/inmunología , Resultado del TratamientoRESUMEN
68 children aged 3-7 years, undergoing general sanative treatment in a bronchopulmonary sanatorium in the vicinity of Moscow between November 10 and December 29, 1990, were examined. During the stay of these children in the sanatorium cases of respiratory diseases, mainly of parainfluenza etiology, were registered, which was confirmed by serological laboratory studies. At this season no cases of Legionella and Mycoplasma infections were detected. The necessity of taking prophylactic measures with the use of reaferon and lysozyme in sanative groups of children in due time, starting from the first day of the formation of such group, was substantiated.
Asunto(s)
Colonias de Salud , Infecciones del Sistema Respiratorio/epidemiología , Infecciones del Sistema Respiratorio/prevención & control , Enfermedad Aguda , Anticuerpos Antibacterianos/sangre , Anticuerpos Antivirales/sangre , Niño , Preescolar , Humanos , Infecciones del Sistema Respiratorio/inmunología , Estaciones del Año , Estudios Seroepidemiológicos , U.R.S.S./epidemiologíaAsunto(s)
Virus de la Influenza B , Gripe Humana/epidemiología , Estaciones del Año , Factores de Edad , Instituciones de Atención Ambulatoria/estadística & datos numéricos , Niño , Preescolar , Brotes de Enfermedades/estadística & datos numéricos , Hospitales Pediátricos/estadística & datos numéricos , Humanos , Lactante , Gripe Humana/complicaciones , Gripe Humana/diagnóstico , Federación de Rusia/epidemiología , SíndromeRESUMEN
The authors describe the results of observation and clinico-laboratory examination of patients during seasonal rises of the rotavirus infection incidence in 5 districts of the Moscow region in 1984-1987. The diseases ran their courses in the form of gastroenteritis and enteritis and were marked by a great number of the grave patterns (42-46%), mainly in children of the first three years of life, by a high percentage (77.5%) of the aggravated premorbid status of patients with the grave patterns. The rotavirus nature of diarrheas was supported by the data of direct electron microscopy, ELISA, and solid-phase coagglutination test. The symptom-complex of the clinical manifestations of rotavirus infection was characterized in detail. The histologic and morphometric data pertaining to two lethal outcomes were discussed. It has been demonstrated that respiratory viral infections, primarily influenza, produced an adverse effect, promoting the formation of the severe patterns and the onset of unfavourable outcomes of rotavirus infection in children.
Asunto(s)
Brotes de Enfermedades , Gastroenteritis/epidemiología , Infecciones por Rotavirus/epidemiología , Estaciones del Año , Preescolar , Gastroenteritis/diagnóstico , Humanos , Lactante , Moscú , Infecciones por Rotavirus/diagnóstico , Población UrbanaRESUMEN
Two children (a 6-month-old girl and a 9-month boy) died from Rotavirus gastroenteritis as evidenced by virological, electron microscopic, and immune fluorescence studies of intestinal tissue. Histological and morphometric examinations of the small intestine revealed acute diffuse enteritis with enlarged and shortened villi, infiltration of intrinsic plates with lymphocytes, plasma cells and macrophages, enhanced mitotic activity of epitheliocytes and their increased lymphocyte-induced infiltration. The hepatic tissue showed central lobular fatty infiltration. The above changes should be regarded as manifestations of Rotavirus infection. Pneumonia detected in one of the children had been caused by influenza infection.