RESUMEN
Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.
Asunto(s)
Vestibulopatía Bilateral/fisiopatología , Endotelio Vascular/fisiopatología , Insuficiencia Vertebrobasilar/fisiopatología , Vértigo/fisiopatología , Adulto , Anciano , Anciano de 80 o más Años , Audiometría , Vestibulopatía Bilateral/diagnóstico por imagen , Vestibulopatía Bilateral/tratamiento farmacológico , Vestibulopatía Bilateral/metabolismo , Biomarcadores/metabolismo , Pruebas Calóricas , Endotelio Vascular/diagnóstico por imagen , Endotelio Vascular/efectos de los fármacos , Endotelio Vascular/metabolismo , Femenino , Glicosaminoglicanos/uso terapéutico , Humanos , Hipoglucemiantes/uso terapéutico , Molécula 1 de Adhesión Intercelular/metabolismo , Masculino , Persona de Mediana Edad , Ultrasonografía Intervencional , Vasodilatación , Insuficiencia Vertebrobasilar/diagnóstico por imagen , Insuficiencia Vertebrobasilar/tratamiento farmacológico , Insuficiencia Vertebrobasilar/metabolismo , Vértigo/diagnóstico por imagen , Vértigo/tratamiento farmacológico , Vértigo/metabolismoRESUMEN
We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain-phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.