RESUMEN
Reactions of amphotericin B, a polyene macrolide antibiotic, with acyl perfluorides resulted in formation of its N-perfluoroacyl derivatives. Physicochemical and medicobiological properties of the derivatives were studied. The biological study revealed that the acute toxity (LD50) of the derivatives was 2 times as low as that of the starting antibiotic. The derivatives showed high antifungal activity against a great number of the test cultures.
Asunto(s)
Anfotericina B/análogos & derivados , Antibacterianos/farmacología , Fluorocarburos/farmacología , Anfotericina B/biosíntesis , Anfotericina B/farmacología , Antibacterianos/biosíntesis , Fenómenos Químicos , Química Física , Fluorocarburos/metabolismo , Dosificación Letal Mediana , Pruebas de Sensibilidad MicrobianaRESUMEN
Reactions of levorin, a polyenic macrolide antibiotic, with aromatic aldehydes and hypophosphorous acid resulted in formation of its amino phenylphosphonium derivatives. Physicochemical and biological properties of the derivatives were studied. The levorin amino phenylphosphonium derivatives were shown to be low toxic and have antifungal and antiviral activities.