RESUMEN

Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 shifted the GABA dose-response curve to the left, but produced no effect on the maximum response (EC50 in control and in the presence of 30 microM RU-353 were 6.9 and 2.0 microM, respectively).

Asunto(s)

Bencimidazoles/farmacología , Canales Iónicos/metabolismo , Células de Purkinje/efectos de los fármacos , Ácido gamma-Aminobutírico/farmacología , Animales , Sinergismo Farmacológico , Agonistas de Receptores de GABA-A , Canales Iónicos/efectos de los fármacos , Células de Purkinje/fisiología , Ratas , Receptores de GABA-A/efectos de los fármacos