RESUMEN

OBJECTIVE: To determine the efficacy of subconjunctival injection of bevacizumab in regressing corneal neovascularisation. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Department of Ophthalmology, Chandka Medical College and Hospital, SMBBMU, Larkana, Pakistan, from October 2015 to March 2016. METHODOLOGY: A total of 95 patients with corneal neovascularisation of more than 3 months' duration and with no history of previous or current anti-VEGF treatment were included in the study. Patients with any other active ocular disease or using any medication were excluded from the study. Subconjunctival injection of bevacizumab 0.05 ml (1.25 mg) was given near the limbus where maximum neovascularisation was seen. The final outcome was assessed after one month of injection; Pre- and post-treatment slit-lamp examination was done and corneal photograph was taken with anterior segment digital camera to see any regression in corneal neovessels from the baseline. RESULTS: Out of the total 95 patients, 62 (65.3%) were males and 33 (34.7%) were females, 18 (18.9%) patients were known cases of diabetes mellitus and 8 (8.4%) had hypertension. Mean age was 38.46 ±10.01 years. Mean duration of corneal neovascularisation was 1.81 ±3.68 years. After subconjunctival injection of bevacizumab, 14.7% patients showed regression in corneal neovascularisation. CONCLUSION: Subconjunctival injection of bevacizumab is a promising modality for treatment of corneal neovascularisation and may be used in adjunct to other therapies.

Asunto(s)

Inhibidores de la Angiogénesis/administración & dosificación , Anticuerpos Monoclonales Humanizados/administración & dosificación , Bevacizumab/administración & dosificación , Neovascularización de la Córnea/tratamiento farmacológico , Adulto , Inhibidores de la Angiogénesis/uso terapéutico , Bevacizumab/uso terapéutico , Conjuntiva , Relación Dosis-Respuesta a Droga , Femenino , Humanos , Inyecciones , Inyecciones Intraoculares/métodos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento

RESUMEN

OBJECTIVE: To document the clinical presentation of neglected DDH and evaluate the outcome of triple procedure. METHODS: It was a descriptive case series study, conducted at the Department of Orthopedic Surgery, National Institute of Rehabilitation Medicine (NIRM), Islamabad over a period of 8-years. It included children aged >1 and <9 years who underwent the triple procedure of open reduction, femoral shortening and Salter's osteotomy. Clinical evaluation was performed using McKay's criteria. Tonnis classification and Severin's scoring system were employed for the radiological evaluation. RESULTS: There were 193 children with 213 DDH affected hips. The mean age was 3.31±1.6 years. The preoperative severity of the femoral head dislocation per Tonnis classification was Grade-I in 7.98%(n=17), Grade-II in 48.35%(n=103) and Grade-III in 43.66%(n=93) hips. The postoperative MacKay criteria was 'Good' to 'Excellent' in 193(90.61%) hips. The postoperative Severin's class was I in 113(53%) hips, II in 48(22.53%) hips, III in 43(20.18%) and IV in 9(4.22%) hips. The preoperative acetabular index ranged from 39° to 51° with a mean of 43.91±3.69°. The mean postoperative AI was 18.42±2.99°. The postoperative centre edge angle ranged from 21° to 26° with a mean 23.18 ±1.35°. CONCLUSIONS: The single stage triple procedure offers the surgical remedy of choice with favourable results for managing neglected and late diagnosed DDH among children aged 1-8 years.