RESUMEN
The aim was to study bioinformatics involvement of candidate genes of cytokines in the formation of large fibroids in women with uterine cancer in older age groups. Genotyping of 15 molecular genetic markers cytokines was performed in 120 patients with uterine myoma with large myoma nodes and 107 patients with myoma nodes of small size. The study found that genetic risk factors for fibroids with large uterine fibroids are two combinations of genetic variants: G SDF-1, CC IL-1ß, A RANTES (OR=5,56) and A RANTES with genotype CC IL-1ß (OR=4,60). 12 of 15 polymorphic loci studied in various combinations (8 revealed significant combinations) have protective value in the formation of large fibroids with uterine cancer (OR=0,09-0,31).
Asunto(s)
Citocinas/genética , Leiomioma , Neoplasias Uterinas , Adulto , Anciano , Biología Computacional/métodos , Femenino , Estudios de Asociación Genética/métodos , Humanos , Leiomioma/genética , Leiomioma/patología , Persona de Mediana Edad , Federación de Rusia , Carga Tumoral , Neoplasias Uterinas/genética , Neoplasias Uterinas/patologíaRESUMEN
The study analyzed 301 patients with uterine cancer at the age of 45 years and older and 304 patients with uterine myoma 45 years. It was found that patients with uterine myoma of the older age group (45 and older) have the following clinical features: overweight and thus increased BMI these women, a lower percentage of a family history of uterine cancer, a smaller percentage of infertility, a greater number of pregnancies, births, medical abortions, the high prevalence of diseases of the cardiovascular system and pathology of the cervix, large size fibroids and as a consequence more common compartment syndrome adjacent organs by myoma nodes (disuric disorders).
Asunto(s)
Leiomioma , Mioma , Neoplasias Uterinas , Anciano , Índice de Masa Corporal , Femenino , Humanos , Infertilidad Femenina/epidemiología , Leiomioma/patología , Leiomioma/fisiopatología , Anamnesis/métodos , Persona de Mediana Edad , Mioma/patología , Mioma/fisiopatología , Sobrepeso/diagnóstico , Sobrepeso/epidemiología , Historia Reproductiva , Estadística como Asunto , Carga Tumoral , Neoplasias Uterinas/patología , Neoplasias Uterinas/fisiopatologíaRESUMEN
The article presents an overview of the problem of varicose veins of pelvic (VVP) in elderly women. VVP is severe suffering to women, especially in the elderly, it promotes social exclusion, leads to psychoemotional disorders and occurrence of chronic pelvic pain due to pelvic varicose veins transformation. Despite the 150-year history of the disease, there is still no clear understanding of the clinical picture of the disease and, most importantly, how to treat this condition. In this regard, it is highly relevant research on timely diagnosis and appropriate treatment of VVP.
Asunto(s)
Geriatría , Pelvis/irrigación sanguínea , Várices/epidemiología , Factores de Edad , Anciano , Femenino , Salud Global , Humanos , IncidenciaAsunto(s)
Conducto Auditivo Externo/lesiones , Enfermedades del Oído/cirugía , Cuerpos Extraños/cirugía , Traumatismos Mandibulares/cirugía , Nasofaringe/lesiones , Heridas Penetrantes/cirugía , Adulto , Conducto Auditivo Externo/diagnóstico por imagen , Conducto Auditivo Externo/cirugía , Enfermedades del Oído/diagnóstico por imagen , Cuerpos Extraños/diagnóstico por imagen , Humanos , Masculino , Traumatismos Mandibulares/diagnóstico por imagen , Nasofaringe/diagnóstico por imagen , Nasofaringe/cirugía , Tomografía Computarizada por Rayos X , Traqueostomía , Heridas Penetrantes/diagnóstico por imagenRESUMEN
To study the specific features of the epileptic syndrome after present-day gunshot cranial wounds (GCW), as well as risk factors of its occurrence, 56 victims were examined prospectively (within at least a year after their admission). The epileptic syndrome developed in 18 (32.1%) patients within 1 to 15 months following GCW; there were prevalent generalized convulsive (in 13 of the 18 patients) and focal (in 12 of the 18 ones) seizures. One type of seizures was noted in 7 patients, two or three ones were in 11. The polymorphism of seizures and a disparity of their psychopathological structure to the side of brain lesion were typical for left-handers. As compared to other patients, epileptics were more commonly found to have: 1) frontoparietal lesion; 2) multiple bony defects of the vault of the skull; 3) enlargement of the lateral ventricle of the brain on CT scans; 4) primary coma for > 2 hours and other depressed consciousness syndromes for > 1 day; 5) signs of left-handedness. The findings suggest that there is a need for studies of the functional asymmetry of the brain to gain a better insight into the problem.
Asunto(s)
Epilepsia Postraumática/etiología , Traumatismos Penetrantes de la Cabeza/complicaciones , Heridas por Arma de Fuego/complicaciones , Adolescente , Adulto , Anciano , Niño , Epilepsia Postraumática/psicología , Femenino , Traumatismos Penetrantes de la Cabeza/psicología , Humanos , Masculino , Persona de Mediana Edad , Personal Militar , Estudios Prospectivos , Psicopatología , Factores de Riesgo , Federación de Rusia , Síndrome , Factores de Tiempo , Heridas por Arma de Fuego/psicologíaRESUMEN
Blood plasma levels of medium-mass molecules (MMM), antioxidant activity (AOA), and malonic dialdehyde (MDA) were measured in 51 neurosurgical patients before and directly and 24 h after intravenous drip infusion of sodium hypochlorite (SHC) solution. Preliminary in vitro studies showed the most expressed drop of initially high MDA and MMM levels to be associated with an increase of AOA. It was observed at SHC concentration of 0.05 mg/ml, corresponding to infusion of SHC in a concentration of 600 mg/liter in 0.1 of the total circulating blood volume. Even a single dose of SHC alleviated endogenous intoxication and decreased the concentration of MMM and lipid peroxidation products. The proper AOA of the blood did not drop in this case, and in patients with initially low AOA it appreciably increased. Infusion of SHC normalized the values of Kp, which reflected its high detoxifying activity in endogenous poisoning caused mainly by inflammatory changes.
Asunto(s)
Antioxidantes/análisis , Lesiones Encefálicas/cirugía , Neoplasias Encefálicas/cirugía , Inflamación/terapia , Malondialdehído/sangre , Hipoclorito de Sodio/administración & dosificación , Desintoxicación por Sorción/métodos , Lesiones Encefálicas/metabolismo , Neoplasias Encefálicas/metabolismo , Humanos , Inflamación/metabolismo , Infusiones Intravenosas , Peroxidación de Lípido , Peso MolecularRESUMEN
Fifteen patients with posttraumatic epilepsy (10 men and 5 women aged 15 to 47) were examined in 1990-1991. All the patients had a history of craniocerebral injury (closed in 7 and open in 8 cases), 6 of them were operated on for intracranial hematomas. Besides CAT, electroencephalography, craniography, and examination of the fundus oculi were carried out. CAT was performed with a Ct MAX (General Electric) unit. Standard positioning of the patients with sectional projections parallel to the orbital meatal line was used. Changes in the brain matter were detected in 13 of these 15 patients: foreign bodies (2 cases), meningeal cerebral cicatrices (5), dilatation of the ventricular system (4), petrificates in the brain matter (1), atrophic changes of the cerebral cortex (1). The tomograms of two patients were normal. Ten patients were operated on: 2 were subjected to anterior callosotomy, in 2 foreign bodies were removed, and in 6 patients staged plasty with removal of the meningeal cerebral cicatrix was carried out. The detected CAT changes helped diagnose the topical location of the epileptogenic focus and choose the optimal method of surgery for posttraumatic epilepsy.