RESUMEN
The distributions of the alleles and genotypes of Polymorphic markers D6S2414 and D6S1271 located among class II MHC genes have been studied in patients with chronic glomerulonephritis (CGN) and healthy donors. Both markers have been found to be associated with the disease. Since these microsatellites are located in the chromosomal region occupied by class II MHC genes, their association with CGN indirectly indicates that class II MHC genes are involved in the development of this pathology.
Asunto(s)
Genes MHC Clase II/genética , Glomerulonefritis/genética , Antígenos HLA-D/genética , Polimorfismo Genético , Adolescente , Adulto , Anciano , Enfermedad Crónica , Femenino , Frecuencia de los Genes , Marcadores Genéticos , Humanos , Masculino , Persona de Mediana Edad , Moscú , Población Blanca/genéticaRESUMEN
In groups of type 1 diabetes mellitus patients with and without clinical signs of diabetic nephropathy (n = 62 and n = 68, respectively), a search was made for associations between diabetic nephropathy and the polymorphic marker epsilon2/epsilon3/epsilon4 of apolipoprotein E gene (APOE), I/D marker of apolipoprotein B gene (APOB), and Ser447Ter marker of lipoprotein lipase-encoding gene (LPL). The risk of diabetic nephropathy was higher in the carriers of allele epsilon3 and genotype epsilon3/epsilon3 of the polymorphic marker epsilon2/epsilon3/epsilon4 of APOE gene as well as in the carriers of allele 1 and APOB genotype/gene (OR = 2.08 and 2.16; 1.91 and 2.11, respectively). Conversely, the carriers of allele D showed a reduced risk of this complication (OR = 0.52). No significant differences in distribution of alleles and genotypes of the polymorphic marker Ser447Ter of LPL gene were found between the groups. Our results indicate that the genes encoding two major components of lipid metabolism are involved in the development of diabetic nephropathy in patients with type 1 diabetes mellitus.