RESUMEN

The first enantioselective total syntheses of two marine sesquiterpenes (1R)-suberosenone and (1R)-suberosanone are achieved leading to revision of the AC of natural (1S)-suberosanone. Key elements of the synthesis include hyperbaric asymmetric Michael addition and highly efficient silver trifluoroacetate mediated α-alkylation for the formation of ring A.

Asunto(s)

Antineoplásicos/síntesis química , Antineoplásicos/farmacología , Sesquiterpenos/síntesis química , Sesquiterpenos/farmacología , Antineoplásicos/química , Línea Celular Tumoral , Técnicas de Química Sintética , Humanos , Sesquiterpenos/química , Estereoisomerismo