Asunto(s)
Neoplasias Óseas/terapia , Sarcoma/terapia , Neoplasias de los Tejidos Blandos/terapia , Adolescente , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Óseas/diagnóstico , Niño , Terapia Combinada , Femenino , Humanos , Neoplasias Pulmonares/secundario , Metástasis Linfática , Masculino , Persona de Mediana Edad , Pronóstico , Radioterapia Adyuvante , Sarcoma/diagnóstico , Sarcoma/secundario , Neoplasias de los Tejidos Blandos/diagnóstico , Procedimientos Quirúrgicos OperativosRESUMEN
The incidence of cancer rises with age. From epidemiologic and clinical viewpoints, cancer differs significantly among different age groups. The symptoms and signs are often masked by the more frequent debilities of old age. A few sites account for the majority of cancers in the elderly. No patient should be denied the full use of any appropriate form of therapy on the grounds of old age alone.
Asunto(s)
Anciano , Neoplasias/epidemiología , Envejecimiento , Neoplasias de la Mama/epidemiología , Neoplasias del Colon/epidemiología , Femenino , Humanos , Masculino , Neoplasias/diagnóstico , Neoplasias/terapia , Pronóstico , Neoplasias de la Próstata/epidemiología , Neoplasias del Recto/epidemiologíaAsunto(s)
Neoplasias/epidemiología , Anciano , Neoplasias de la Mama/epidemiología , Femenino , Neoplasias Gastrointestinales/epidemiología , Neoplasias de los Genitales Femeninos/epidemiología , Humanos , Leucemia/epidemiología , Masculino , Melanoma/epidemiología , Persona de Mediana Edad , Mieloma Múltiple/epidemiología , Neoplasias/diagnóstico , Neoplasias/terapia , Pronóstico , Neoplasias de la Próstata/epidemiología , Neoplasias Cutáneas/epidemiología , Neoplasias de la Tiroides/epidemiología , Estados Unidos , Neoplasias de la Vejiga Urinaria/epidemiologíaRESUMEN
A patient with a choledochal T tube and normal liver function received adriamycin as therapy for abdominal histiocytic lymphoma. Plasma, urine, and bile samples were collected after drug administration. Adriamycin and its metabolites were extracted from the samples and separated by thin-layer chromatography. The pharmacokinetics of adriamycin and metabolites in plasma urine resembled those of previous patients, with a plasma elimination half-life for adriamycin of 25.2 hr. Bile contained adriamycin and 11 metabolites, 4 of which were not present in plasma or urine. Forty-one percent of the administered dose of adriamycin appeared in the bile in 7 days; of this amount, 42% was adriamycin, 22% was adriamycinol, the major metabolite, and 36% was other metabolites. Hepatic clearances of adriamycin and adriamycinol showed early, rapid removal of drug by the liver, with subsequent slowing of removal rate as plasma drug concentration declined. Adriamycin was more efficiently cleared than adriamycinol by both liver and kidney. Disease states which impair the capacity of the liver to excrete adriamycin may result in prolonged, high drug levels and increased toxicity.
Asunto(s)
Bilis/metabolismo , Doxorrubicina/metabolismo , Adulto , Biotransformación , Doxorrubicina/sangre , Doxorrubicina/orina , Humanos , Masculino , Factores de TiempoRESUMEN
Apparent spontaneous regression of advanced colon carcinoma has been reported in 7 patients. This is a very rare event, and the circumstances accounting for this are elusive.
Asunto(s)
Neoplasias del Colon/patología , Regresión Neoplásica Espontánea , Neoplasias del Colon/inmunología , Femenino , Humanos , Neoplasias Hepáticas/patología , Masculino , Metástasis de la Neoplasia , Neoplasias del Recto/patologíaRESUMEN
Eighteen of 54 adults with acute leukemia developed severe hypocalcemia during a 20 month period. Hypocalcemia (mean lowest serum calcium 6.3 mg/100 ml with a range of 4.1 to 7.0 mg/100 ml) lasted 2-29 days and was symptomatic in all but one patient. Six patients were hypocalcemic at the time of death, 5 died within 1 week of hypocalcemia, and 2 had antibiotic-induced respiratory arrest. All patients had severe infections; 17 of 18 were with gram-negative organisms. No patient had severe azotemia, diarrhea, alkalosis, or hypoalbuminemia. Hypophosphatemia was seen in 14 patients, suggesting no hypoparathyroidism. The serum calcium of patients with acute leukemia should be measured frequently, especially when they have infection. Hypocalcemia is a sign of poor prognosis and should signal the need for careful observation of ventilation, caution in the use of aminoglycoside antibiotics, and vigorous attempts at calcium administration.