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INTRODUCCIÓN: El tabaquismo continúa siendo un problema sanitario en población universitaria y profesionales de la salud. Los kinesiólogos participan en la implementación de programas orientados a la prevención y cese del tabaquismo en la comunidad. El objetivo de este estudio fue explorar la prevalencia de tabaquismo y actitudes sobre consumo de tabaco en estudiantes de kinesiología. MÉTODOS: Estudio de corte transversal realizado en estudiantes de Kinesiología de Concepción (Chile), durante los años 2017 y 2018. Se determinó la conducta y actitudes sobre tabaquismo. Mediante regresión logística se determinó la asociación entre la conducta fumadora y las actitudes sobre tabaquismo. Se consideró un valor de p < 0,05 como estadísticamente significativo. RESULTADOS: Se contestaron 554 cuestionarios. El 57,8% de los estudiantes encuestados declaró no haber fumado nunca, 13 % no haber fumado los últimos 6 meses y 29,4% declaró ser fumador actual. Por su parte, el 99,5% expresó algún grado de acuerdo con que fumar es perjudicial para la salud, lo cual se relacionó con la conducta fumadora (p < 0,0002). En relación a actitudes sobre tabaquismo, comparado a los no fumadores, los fumadores actuales presentan mayor probabilidad de mostrar desacuerdo o indiferencia respecto a actitudes positivas sobre tabaquismo. Principalmente en aquellas acciones que restringen su consumo, venta y divulgación (OR ponderado = 2,43; 95%IC 2,02 - 2,92). CONCLUSIONES: La prevalencia de tabaquismo en estudiantes de Kinesiología de Concepción es del 29,2%. Los estudiantes fumadores expresan una menor aprobación relacionada a intervenciones, actitudes y consecuencias del tabaquismo para la salud comparada con los no fumadores.

INTRODUCTION: Notwithstanding control policies, smoking continues to be a health problem in university students and health professionals, who are responsible for implementing programs oriented to prevention and cessation of smoking in the community. The objective of this study was to explore the prevalence of smoking and attitudes about smoking in physical therapy students. METHODS: Cross-sectional study carried out in students of physical therapy from three universities of Concepción city (Chile), during the years 2017 and 2018. Behavior and attitudes about smoking were evaluated. Association between smoking behavior and attitudes about smoking was determined by logistic regression. A p value < 0.05 was considered statistically significant. RESULTS: 554 questionnaires were answered. 57.8% of respondents had never smoked, 13.0% had not smoked in the last 6 months and 29.4% were current smokers. Moreover 99.5% of respondents stated some degree of agreement that smoking is harmful to health, which was related to smoking behavior (p < 0.0002). In relation to attitudes about smoking, compared to non-smokers, current smokers have a greater chance of showing disagreement or indifference regarding positive attitudes about smoking. Mainly in those actions that restrict tobacco consumption, sale and disclosure (weighted OR = 2.43, 95% CI 2.02 - 2.92). CONCLUSIONS: The prevalence of current smoking in physical therapy students from Concepcion city is 29.2%. Smoking students express lower approval related to interventions, attitudes and consequences of smoking for health compared with non-smokers.

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La pandemia por COVID-19 ha generado un estancamiento mundial en la atención y resolución de todas las patologías graves y crónicas, debido al colapso de los sistemas de salud, a la dificultad de consulta, dada por la disminución de movilidad de las personas, por las cuarentenas establecidas y también por el temor de los pacientes al contagio en los centros de salud. Los enfermos oncológicos han visto canceladas sus atenciones, suspendidos o postergado sus tratamientos y diferidas sus cirugías. Esto no ha sido ajeno a las pacientes con cáncer de mama. En el presente trabajo, se reporta la experiencia de una Unidad de Patología Mamaria de un hospital público de Santiago de Chile y de las acciones realizadas para mantener la continuidad de atención en una comuna con una alta tasa de infección por SARS-CoV-2.

The COVID-19 pandemic has generated a global stagnation in the care and medical treatment of serious and chronic illnesses due to the collapse of the health systems, the difficulty of consulting due to decreased mobility caused by forced quarantines and also because of the fear of infection when attending a health center. Cancer patients have had their medical appointments canceled, their treatments suspended or postponed, and their surgeries delayed. Breast cancer patients have not been the exception. We report the experience of a Breast Pathology Unit of a public hospital in Santiago of Chile, and the actions carried out to maintain continuity of care in a community with a high infection rate of SARS-CoV-2.

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OBJECTIVE: To describe potential regional variations in therapies for severe asthma exacerbations in Chilean children and estimate the associated health expenditures. METHODS: Observational prospective cohort study in 14 hospitals over a one-year period. Children five years of age or older were eligible for inclusion. Days with oxygen supply and pharmacological treatments received were recorded from the clinical chart. A basic asthma hospitalization basket was defined in order to estimate the average hospitalization cost for a single patient. Six months after discharge, new visits to the Emergency Room (ER), use of systemic corticosteroids and adherence to the controller treatment were evaluated. RESULTS: 396 patients were enrolled. Patients from the public health system and from the north zone received significantly more days of oxygen, systemic corticosteroids and antibiotics. Great heterogeneity in antibiotic use among the participating hospitals was found, from 0 to 92.3% (ICC 0.34, 95% CI 0.16-0.52). The use of aminophylline, magnesium sulfate and ketamine varied from 0 to 36.4% between the different Pediatric Intensive Care Units (ICC 0.353, 95% CI 0.010-0.608). The average cost per inpatient was of $1910 USD. 290 patients (73.2%) completed the follow-up six months after discharge. 76 patients (26.2%) were not receiving any controller treatment and nearly a fourth had new ER visits and use of systemic corticosteroids due to new asthma exacerbations. CONCLUSIONS: Considerable practice variation in asthma exacerbations treatment was found among the participating hospitals, highlighting the poor outcome of many patients after hospital discharge, with an important health cost.

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BACKGROUND: Asthma hospitalization rates in Chilean children have increased in the last 14 years, but little is known about the factors associated with this. OBJECTIVE: Describe clinical characteristics of children hospitalized for asthma exacerbation. METHODS: Observational prospective cohort study in 14 hospitals. Over a one-year period, children five years of age or older hospitalized with asthma exacerbation were eligible for inclusion. Parents completed an online questionnaire with questions on demographic information, about asthma, indoor environmental contaminant exposure, comorbidities and beliefs about disease and treatment. Disease control was assessed by the Asthma Control Test. Inhalation technique was observed using a checklist. RESULTS: 396 patients were enrolled. 168 children did not have an established diagnosis of asthma. Only 188 used at least one controller treatment at the time of hospitalization. 208 parents said they believed their child had asthma only when they had an exacerbation and 97 correctly identified inhaled corticosteroids as anti-inflammatory treatment. 342 patients used the wrong spacer and 73 correctly performed all steps of the checklist. CONCLUSIONS: Almost half of the patients were not diagnosed with asthma at the time of hospitalization despite having a medical history suggestive of the disease. In the remaining patients with an established diagnosis of asthma potentially modifiable factors like bad adherence to treatment and poor inhalation technique were found. Implementing a nationwide asthma program including continued medical education for the correct diagnosis and follow up of these patients and asthma education for patients and caregivers is needed to reduce asthma hospitalization rates in Chilean children.

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We simulated the frequency of tuberculosis infection in healthcare workers in order to classify the risk of TB transmission for nine hospitals in Medellín, Colombia. We used a risk assessment approach to estimate the average number of infections in three risk groups of a cohort of 1082 workers exposed to potentially infectious patients over 10- and 20-day periods. The risk level of the hospitals was classified according to TB prevalence: two of the hospitals were ranked as being of very high priority, six as high priority and one as low priority. Consistent results were obtained when the simulation was validated in two hospitals by studying 408 healthcare workers using interferon gamma release assays and tuberculin skin testing. The latent infection prevalence using laboratory tests was 41% [95% confidence interval (CI) 34·3-47·7] and 44% (95% CI 36·4-51·0) in those hospitals, and in the simulation, it was 40·7% (95% CI 32·3-49·0) and 36% (95% CI 27·9-44·0), respectively. Simulation of risk may be useful as a tool to classify local and regional hospitals according to their risk of nosocomial TB transmission, and to facilitate the design of hospital infection control plans.

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OBJETIVO: identificar la percepción de exclusión social y sus dimensiones demográfica, económica, de participación social y política y su asociación con la calidad de vida relacionada con la salud en las personas de 25 a 60 años de la zona nororiental de Medellín - Colombia, 2009. METODOLOGIA: se condujo un estudio transversal de asociación. El tamaño muestral se calculó con un nivel de confianza de 95%, un error de 4,5% y una proporción de 0,28 derivada de la investigación sobre exclusión social realizada en Medellín en el año 2008, para un total de 404 sujetos. La muestra fue obtenida mediante un muestreo probabilístico, por conglomerados, polietápico, proporcional por sexo sin reemplazo. Los datos se analizaron en el software SPSS v.15.0 y StataSE 10. RESULTADOS: el 22,8% de la población se percibió en situación de exclusión social. En la evaluación de la Calidad de vida relacionada con la salud (CVRS) se encontraron altos puntajes en todos los dominios del cuestionario SF-36, presentándose diferencias significativas en los puntajes del Desempeño Físico (p = 0,000), Desempeño Emocional (p = 0,000) y Salud Mental (p = 0,023), teniendo mayores puntajes en estos dominios las personas no excluidas. Conclusiones: los resultados sugieren que la percepción de exclusión social afecta la CVRS y las condiciones individuales de salud pueden incidir en la percepción de exclusión social. Esto puede deberse a que la salud (enfermedad) en sí es un generador de exclusión social o que la prestación de los servicios de salud en el sistema de salud colombiano, haga que las personas enfermas se sientan excluidas.

OBJECTIVE: to identify the perception of social exclusion and its demographic, economic, and sociopolitical participation dimensions as well as its association with the Health-Related Quality of Life (HRQOL) of people aged 25 to 60 living in the northeastern area of Medellin - Colombia, 2009. METHODOLOGY: a cross-sectional study of association was conducted. The sample size was calculated with a confidence level of 95%, an error of 4.5%, and a ratio of 0.28 derived from a study on social exclusion conducted in Medellín in 2008. The study was conducted with a total of 404 subjects. The sample was obtained through a probability, cluster, and multistage sampling that was proportional by sex and had no replacement. The data was analyzed using the SPSS v.15.0 and Stata 10 software. RESULTS: 22.8% of the population was perceived to be in a situation of social exclusion. The assessment of the Health-Related Quality of Life (hrqol) showed high scores in all the domains of the SF-36 questionnaire. Significant differences were observed in role physical (p = 0.000), role emotional (p = 0.000), and Mental Health (p = 0.023) scores. Non-excluded individuals showed higher scores in these domains. CONCLUSIONS: the results suggest that the perception of social exclusion affects HRQOL and individual health conditions may affect the perception of social exclusion. This may be due to the fact that health (disease) in itself generates social exclusion or that the healthcare services in the Colombian health system cause sick people to feel excluded.

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Giant cell tumor (GCT) is a benign, locally aggressive lesion that primarily affect the long bones epiphyses, which represents 5-9 percent of the bone primary tumors. The purpose of this study is to show the Instituto Traumatológico‘s orthopaedic oncology group experience in the treatment of GCT and suggest a scheme of treatment according to Campanacci’s stage. For which a retrospective study was done, that include 112 patients treated from 1987 to 2007. The average time of follow-up was 9, 2 years, most frequent location was the knee region (69 percent). 85 patients (76 percent) were in stage 3 of Campanaci’s classification. We used different surgical alternatives from basic curettage to resection plus reconstruction with prostheses or aloprostheses. Post surgical complications were seen in 16 patients(14 percent). In the follow-up we had 8 pseudoarthrosis, 7 osteosintesis material failure and 3 allograft fractures. Local recurrence was seen in 15 patients (13,3 percent). 3 cases presented pulmonary metastases (2,6 percent). Mean functional evaluation, using Musculo Skeletal Tumor Society (MSTS) score, was 25, 6 points.

El Tumor de Células Gigantes (TCG) óseo es una neoplasia benigna, localmente agresiva, representa entre el 5-9 por ciento de los tumores óseos primarios. El objetivo del estudio fue revisar la experiencia de nuestra Institución en el tratamiento quirúrgico de esta neoplasia y sugerir un esquema de tratamiento según la etapa de Campanacci. Para esto se realizó un estudio retrospectivo que incluyó 112pacientes tratados desde el año 1987 hasta 2007. El tiempo promedio de seguimiento fue de 9,2 años, el tumor se ubicó alrededor de la rodilla en 78 pacientes (69 por ciento). 85 casos (76 por ciento) se encontraban en etapa III de Campanacci. Utilizamos distintas alternativas quirúrgicas desde el curetaje simple a la resección más reconstrucción con prótesis o aloinjerto. Dieciséis pacientes (14 por ciento) presentaron complicaciones post operatorias. A largo plazo hubo 8 pseudoartrosis, 7 fallas del material de osteosíntesis y 3 fracturas del aloinjerto. Recidivaron 15 pacientes (13,3 por ciento). Tres casos presentaron metástasis pulmonares (2,6 por ciento). La evaluación funcional promedio con la escala de la Musculo Skeletal Tumor Sociaty (MSTS) realizada al año del post operatorio, fue de 25,6 puntos.

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Pelvic resection surgeries due to primary bone tumors are infrequent. According to the compromised area we can divide it in three zones, being those who affect the acetabulum the ones with the major functional alterations, pelvic stability and leg length discrepancy. The aim of this study is to present our experience in the surgical management of this type of lesions. From series of 17 patients, eight (47 percent) presented complications, the most frequents was surgical wound infection (23 percent) and deep venous thrombosis (18 percent). 4 patients died (23 percent). The other 13 patients answered the Musculo Skeletal Tumor Society (MSTS) scale being the average score 22,3. One local recurrence appeared in this group. The acceptance of the patients in this kind of surgeries is very good. These surgeries are complex, there is a high rate of complications. They must be performed in centers with a suitable professional and technical equipment.

Las cirugías de resecciones pélvicas por tumores óseos primarios son infrecuentes. Según el área comprometida se divide principalmente en 3 zonas, siendo las que afectan al acetábulo las que producen mayor alteración (funcional, en la estabilidad pélvica y la longitud de las extremidades inferiores). El objetivo de este trabajo es presentar la experiencia del equipo de tumores del Instituto Traumatológico y la Clínica Santa María en el manejo quirúrgico de este tipo de lesiones. Con un total de 17 pacientes, 8 presentaron complicaciones (47 por ciento), la más frecuente fue la infección de herida operatoria (4 pacientes 23 por ciento) y la trombosis venosa profunda (3 pacientes 18 por ciento). Cuatro pacientes (24 por ciento) fallecieron, los 13 restantes respondieron la escala Musculo Skeletal Tumor Society (MSTS) siendo el puntaje promedio de 22,3. Se presentó una recidiva local en este grupo. El grado de aceptación de los pacientes es muy bueno. Deben realizarse en centros con el equipamiento profesional y técnico adecuado para las exigentes y complejas cirugías a realizar.

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Se presentan los resultados de un protocolo prospectivo y cooperativo para el tratamiento del sarcoma de Ewing esquelético. Se evaluaron 27 pacientes (16 hombres, 11 mujeres) con rango de edades de 12 a 34 años. Fueron tratados por un equipo multidisciplinario y multicéntrico (Instituto Traumatológico Dr. Teodoro Gebauer e Instituto Nacional del Cáncer Dr. Caupolicán Pardo C. con un esquema protocolizado de quimioterapia, radioterapia y cirugía conservadora. La mediana de observación fue de 5,3; con un seguimiento de 100 por ciento. Se describe la importancia de un tratamiento controlado y de una buena etapificación previa al inicio del protocolo. La localización más frecuente se presentó en fémur proximal y pelvis (48,3 por ciento). En 22 casos (21,4 por ciento) se encontró la forma localizada, sin metástasis. En 11 de ellos el tumor al momento del diagnóstico tenía un tamaño mayor a 8 cm. Cinco de los pacientes presentaron recidiva local después de haber realizado todo el tratamiento. Para la evaluación funcional se usó la escala de Mankin y la MSTS encontrándose que 18 pacientes (66,6 por ciento) tuvieron un resultado excelente o bueno. Para evaluar la sobrevida se utilizó la Tabla actuarial de Kaplan-Meier. Se concluye que se trata de un protocolo que da buenos resultados y que se puede realizar en nuestro país

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El sarcoma de Ewing es un tumor óseo descrito en 1921 por James Ewing; su origen aún no ha sido aclarad o aunque actualmente se postula un orígen neural. Se encuentra ubidado en el segundo lugar de frecuencia dentro de los tumores óseos primarios malignos, después del osteosarcoma. Comprende alrededor del 10 por ciento de todos los tumores óseos malignos. Es una neoplasia de alto grado de malignidad que se presenta con más frecuencia en la primera década de la vida (5-15 años) particularmente en pacientes de sexo masculino; rara vez se observa en pacientes mayores de 30 años. Su localización más característica corresponde a la región metafisodiafisiaria de los huesos largos (66 por ciento), seguida de los huesos planos (33 por ciento). Se debe hacer el diagnóstico diferencial con: la osteomielitis aguda, osteomielitis crónica reagudizada, granuloma eosinófilo y con el osteosarcoma de células pequeñas. Su diagnóstico es clínico y radiológico, siendo este último elemento de gran importancia. Dentro de la radiología son de utilidad la radiografía simple, el TAC local, el TAC de tórax y el cintigrama óseo. Otros métodos diagnósticos de apoyo son la biopsia, el mielograma, la inmunohistoquímica y la citogenética. En relación a su tratamiento, se utiliza la radioterapia, quimioterapia y la cirugía conservadora

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Se presentan los resultados de un protocolo prospectivo de tratamiento combinado de quimioterapia y cirugía conservadora para el osteosarcoma clásico en etapas I A a II B (Enneking). Se evaluaron 64 pacientes, 39 hombres y 25 mujeres, con edades en rango de 14-60 años. La mediana de seguimiento fue de 40 meses (mínimo 20 y máximo de 72). Todos los pacientes fueron tratados con: doxorrubicina, cisplatino, ifosfamida y mesna en tres ciclos preoperatorios y ciclos postoperatorios, realizándose cirugía conservadora de reemplazos protésicos, alo o autoinjertos. La sobrevida actuarial fue de 60,2 por ciento a los 72 meses de observación. Se describe la relación del diagnóstico tardío con la incidencia de metástasis y sobrevida. Se enfatiza el buen resultado funcional y se recomienda el uso del protocolo presentado

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To help assess the causes and frequency of acute respiratory illnesses (ARI) during the first 18 months of life in Chile, a cohort of 437 children born in good health between May 1991 and April 1992 was followed at an urban health clinic in northern Santiago. Information was obtained from medical checkups performed at the clinic, from emergency health care services, from private physicians, and from interviews with each child's mother when the child was enrolled in the study and when it was 6, 12, and 18 months old. Followup was completed for 379 (87%) of the children. ARI accounted for 67% of all 3762 episodes of illness recorded for these children in the 18-month study period, 1384 (55%) of the ARI episodes affecting the upper respiratory tract and the remaining 1144 (45%) affecting the lower. The overall rate of ARI observed was 33 episodes per 100 child-months of observation. The incidences of upper, lower, and total ARI episodes decreased significantly in the third six months of life. A statistically significant association was found between upper ARI (> or = 2 episodes) and maternal smoking (> or = 5 cigarettes per day), but no significant associations were found with any of the other risk factors studied. However, lower ARI (> or 2 episodes) was significantly associated with maternal schooling (< 8 years), a family history of atopic allergy, and substandard housing conditions; and lower ARI (> or = 4 episodes) was significantly associated with these factors and also with the existence of one or more siblings, birth in a cold season, limited breast-feeding (< 4 months), and low socioeconomic status. Significant associations were found between obstructive bronchitis episodes and most of the risk factors studied (gender, siblings, season of birth, duration of breast-feeding, maternal schooling, smoking, use of polluting fuels in the home, and a family history of atopic allergy); similarly, significant associations were found between the occurrence of pneumonia and many risk factors (including siblings, season of birth, duration of breast-feeding, maternal schooling, smoking, and socioeconomic level). Overall, 42 of the study children were hospitalized during the study period for lower tract ARI, and two children died of pneumonia at home during their first 6 months of life. The rate of hospitalization fell significantly with increasing age.

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BACKGROUND: Each year, pneumonia is the cause of death of forty thousand children under four years of age in America. AIM: To follow children from birth until two years of age and record episodes of pneumonia, their features and associated factors. PATIENTS AND METHODS: Four hundred thirty seven healthy newborns were followed in a public out patient clinic of Northern Santiago until two years of age. Pneumonia was diagnosed using clinical or radiological criteria. The mothers of each child were interviewed in each follow up visit. RESULTS: Two hundred ten episodes of pneumonia were detected during the study, 0.6 episodes per child and 1.8 episodes per affected child. Sixty six percent of episodes occurred during the first year of age. Total prevalence was 22.4 and 14.3% during the first and second year of age respectively. Semi annual incidence was 13.8 and 5.5% during the first and fourth semester respectively. Children that had pneumonia, were male in a higher proportion, had a lower birth weight, had higher number of brothers, mothers with less that 8 years of school courses and a lower socioeconomic level. During the first year of life, breast feeding during less than four months and a birth date during spring and summer were associated with a higher incidence of pneumonia. Seventy seven episodes, that occurred in 48 children, required hospitalization. The hospitalization rate for the whole cohort was 13.4% percent and 41.2% for affected children. Mean hospital stay was 5.8 days. Risk factors for hospitalization were male sex, less than four months of breast feeding, low birth weight, to have brothers, a lower mother education and lower socioeconomic level. Two children died. CONCLUSIONS: One out of three healthy newborns had pneumonia during the first year of life and a low socioeconomic level was an important risk factor.

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El cordón umbilical normalmente está formado por tres vasos, dos de arterias y una vena. La ausencia congénita de una arteria umbilical oarteria umbilical única (AUU) se ha relacionado con una serie de eventos perinatales desfavorables, tales como recién nacidos de bajo peso, prematuridad, malformaciones fetales y muerte perinatal. Se revisan retrospectivamente 12 casos de AUU con comprobación histológica y se analizan las principales características tanto maternas como perinatales. Se encontró un 58% de prematuridad, un 66% de bajo peso de nacimiento y una letalidad perinatal de 580/1000 RN (cuatro mortinatos y tres mortineonatos). En cinco casos se encontró asociación con malformaciones mayores (42%). Se preconiza una búsqueda dirigida de esta anomalía vascular en el momento del parto, debido a que es un importante índice para detectar malformaciones congénitas asociadas

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UNLABELLED: Clinical utility of the Overload Test with 50 g. of Oral Glucose (PSG) is evaluated, in 513 pregnancies with risk factors for diabetes. Of the 933 PSG which were made, 13.7% were positive (limit value: plasma glucose of much less than 150 mg/dl at 1 hour); the test were made after 20 weeks of gestation in 82.8% of the cases. Of the 128 positive PSG, 73 positive Oral Glucose Tolerance Test were obtained (O'Sullivan criteria). The prevalence of gestational diabetes found in this group was 15.2%. There was no difference on the most frequent risk factors (family history, obesity and macrosomia) between the general population in the study and the group of Gestational diabetes. CONCLUSION: PSG, because of its easy application, low cost and excellent tolerance is a test which should be included among the prenatal routine test as screening for gestational diabetes in our media.

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Se describe la ecotomografía transrectal como método de exploración prostática y se relata una experiencia en 40 pacientes. Se establece la correlación con anatomía patológica en 28 casos operados. 38 de 40 pacientes(95%) tenían próstata aumentada de volumen según la ecografía. En 4 de 38 pacientes el aumento del volumen prostático tenía límites ecográficos poco netos. En ellos se sospechó cancer prostático que fué confirmado con biopsia en 3 casos. El volumen prostático estimado por ecografía fué superior en 16 gramos(X) al encontrarlo en la pieza quirúrgica. Las calcificaciones prostáticas fueron el hallazgo ecográfico mas frecuente

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Ninety-four patients with typhoid fever were treated, at random, with three therapeutic regimens: chloramphenicol alone, chloramphenicol plus oxyphenbutazone, and ampicillin plus oxyphenbutazone. The results are evaluated analyzing the body temperature graph and by serial blood had bone marrow cultures taken at intervals until they became negative. Bacteriologic diagnosis was confirmed by blood culture (39.3%) and/or bone marrow culture (77%). The mean duration of fever was 3.3 days for the group treated with chloramphenicol-oxyphenbutazone, 4.3 for those with chloramphenicol alone and 5 days for the group ampicillin-oxyphenbutazone; at the same time, blood cultures became negative at 4.4, 5.5 and 4.4 days respectively. Negativization of bone marrow cultures was not influenced by the addition of oxyphenbutazone. It is concluded that the influence of oxyphenbutazone in shortening the febrile period or in the negativization of blood cultures is not significant. It is considered that oxyphenbutazone is not an important therapeutic tool in this group of diseases.

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