RESUMEN
OBJECTIVES: To investigate the relationship between mean platelet volume (MPV) and glycometabolic indices, to compare MPV according to HbA1c levels, and to analyse the difference in MPV between patients with and without microvascular complications. METHODS: This retrospective study was conducted on 60 Type 2 diabetic patients and 50 age- and sex-matched non-diabetic controls. We obtained demographic, clinical and laboratory data including MPV, platelet count, fasting and postprandial blood glucose (FBG and PBG), haemoglobin A1c (HbA1c), lipid profile, creatinine, systolic and diastolic blood pressure (BP) in patient and control groups, and diabetic microvascular complications including nephropathy, neuropathy, and retinopathy in the patient group. All analyses were performed using SPSS version 15.0 for Windows. RESULTS: Mean platelet volume in the diabetic group was higher than in the control group (p = 0.001). Mean platelet volume was positively correlated with FBG and HbA1c levels (p = 0.03 and p < 0.001, respectively). It was also negatively related to platelet count (p < 0.001). Mean platelet volume in patients with HbA1c > 7% was significantly higher than those with HbA1c < 7% (p < 0.001). Mean platelet volume was significantly increased in patients with retinopathy compared to those without retinopathy (p = 0.04). CONCLUSION: This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.
OBJETIVOS: Investigar la relación entre el volumen medio de plaquetas (MPV) y los índices glicometabólicos, comparar el MPV según los niveles de HbA1c, y analizar la diferencia de MPV entre los pacientes con y sin complicaciones microvasculares. MÉTODOS: Este estudio retrospectivo se realizó en 60 pacientes diabéticos tipo 2, y 50 controles no diabéticos pareados por sexo y edad. Obtuvimos datos demográficos, clínicos y de laboratorio - incluyendo MPV, conteo de plaquetas, glucosa en sangre en ayunas (FBG) y postprandial (PBG), hemoglobina A1c (HbA1c), perfil lipídico, creatinina, presión arterial (BP) sistólica y diastólica en los grupos de pacientes y de control, así como complicaciones microvasculares diabéticas, incluyendo nefropatía, neuropatía y retinopatía en el grupo de pacientes. Todos los análisis se realizaron utilizando el SPSS versión 15.0para Windows. RESULTADOS: El volumen medio de plaquetas en el grupo diabético fue superior al del grupo control (p = 0,001). El volumen medio de plaquetas guardó una correlación positiva con el FBG y los niveles de HbAlc (p = 0.03 y p < 0.001, respectivamente). También se observó una correlación negativa con el conteo de plaquetas (p < 0.001). El volumen medio de plaquetas en los pacientes con HbA1c > 7% fue significativamente mayor que en aquellos con HbAlc < 7% (p < 0.001). El volumen medio de plaquetas aumentó significativamente en los pacientes con retinopatía en comparación con aquellos sin retinopatía (p = 0,04). CONCLUSIÓN: Este estudio mostró que el aumento de MPV está estrechamente relacionado con un control glicémico pobre, lo cual puede ser un factor de riesgo para la retinopatía diabética. Sin embargo, otros estudios prospectivos son necesarios para evaluar la relación entre MPV, los índices glicémicos, y las complicaciones microvasculares.
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Hemoglobina Glucada , Diabetes Mellitus Tipo 2/fisiopatología , Retinopatía Diabética/fisiopatología , Volúmen Plaquetario Medio , Glucemia , Estudios RetrospectivosRESUMEN
OBJECTIVES: To investigate the relationship between mean platelet volume (MPV) and glycometabolic indices, to compare MPV according to HbA1c levels, and to analyse the difference in MPV between patients with and without microvascular complications. METHODS: This retrospective study was conducted on 60 Type 2 diabetic patients and 50 age- and sex-matched non-diabetic controls. We obtained demographic, clinical and laboratory data including MPV, platelet count, fasting and postprandial blood glucose (FBG and PBG), haemoglobin A1c (HbA1c), lipid profile, creatinine, systolic and diastolic blood pressure (BP) in patient and control groups, and diabetic microvascular complications including nephropathy, neuropathy, and retinopathy in the patient group. All analyses were performed using SPSS version 15.0 for Windows. RESULTS: Mean platelet volume in the diabetic group was higher than in the control group (p = 0.001). Mean platelet volume was positively correlated with FBG and HbA1c levels (p = 0.03 and p < 0.001, respectively). It was also negatively related to platelet count (p < 0.001). Mean platelet volume in patients with HbA1c > 7% was significantly higher than those with HbA1c ≤ 7% (p < 0.001). Mean platelet volume was significantly increased in patients with retinopathy compared to those without retinopathy (p = 0.04). CONCLUSION: This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.