RESUMEN
Cutaneous T cell lymphoma first presenting at the tumor stage is described in three patients, including one with the rarely reported granulomatous mycosis fungoides. The rapid progression and resistance to the currently available treatment modalities seem to characterize this unique form of lymphoma.
Asunto(s)
Micosis Fungoide/patología , Neoplasias Cutáneas/patología , Adulto , Anciano , Terapia Combinada , Humanos , Masculino , Persona de Mediana Edad , Micosis Fungoide/diagnóstico , Micosis Fungoide/terapia , Estadificación de Neoplasias , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/terapiaRESUMEN
Over 300 patients with basal cell epithelioma have been treated with Solcoderm during the past 4 years. The treatment is simple and effective for small superficial lesions and particularly useful in patients with periocular or multiple lesions.
Asunto(s)
Antineoplásicos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica , Carcinoma Basocelular/tratamiento farmacológico , Fármacos Dermatológicos/uso terapéutico , Neoplasias de los Párpados/tratamiento farmacológico , Neoplasias Cutáneas/tratamiento farmacológico , Acetatos/uso terapéutico , Ácido Acético , Cobre/uso terapéutico , Combinación de Medicamentos/uso terapéutico , Humanos , Lactatos/uso terapéutico , Nitratos/uso terapéuticoRESUMEN
Long-term follow-up shows a low recurrence rate for Solcoderm treated small superficial basal cell epithelioma, and a high recurrence rate for larger malignant skin lesions.
Asunto(s)
Antineoplásicos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica , Carcinoma Basocelular/tratamiento farmacológico , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma/tratamiento farmacológico , Fármacos Dermatológicos/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Acetatos/uso terapéutico , Ácido Acético , Ensayos Clínicos como Asunto , Cobre/uso terapéutico , Combinación de Medicamentos/uso terapéutico , Estudios de Seguimiento , Humanos , Lactatos/uso terapéutico , Recurrencia Local de Neoplasia , Nitratos/uso terapéuticoRESUMEN
Double-blind clinical studies of pairs of lesions were initiated to evaluate several components of Solcoderm treatment. The superiority of Solcoderm over plain nitric acid was as evident with plastic as with wooden applicators. A mixture of oxalic and nitric acid had effects similar to Solcoderm, while acetic and nitric acid was similar in effect to plain nitric acid.
Asunto(s)
Antineoplásicos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica , Fármacos Dermatológicos/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Acetatos/administración & dosificación , Acetatos/uso terapéutico , Ácido Acético , Adulto , Antineoplásicos/administración & dosificación , Ensayos Clínicos como Asunto , Cobre/administración & dosificación , Cobre/uso terapéutico , Fármacos Dermatológicos/administración & dosificación , Método Doble Ciego , Combinación de Medicamentos/administración & dosificación , Combinación de Medicamentos/uso terapéutico , Humanos , Lactatos/administración & dosificación , Lactatos/uso terapéutico , Nitratos/administración & dosificación , Nitratos/uso terapéutico , Ácido Nítrico , Oxalatos/uso terapéutico , Ácido Oxálico , Distribución AleatoriaRESUMEN
Distinct differences between topical acid preparations can be detected by simple preclinical and clinical pharmacologic models designed to evaluate potential utility in the treatment of superficial skin tumors. The models distinguish a tissue-dissolving (ulcerating) effect from a tissue-fixation (mummifying) effect, as reflected by a distinct and lasting discoloration of hair in vitro or the skin surface in vivo. Double-blind clinical comparison of the response to different preparations of matched pairs of small superficial skin tumors in 33 subjects demonstrated for greater utility for nitric acid preparations of appropriate strength (6 to 7N), with added oxidizable organic acids, over the mineral acid alone. The nitrate reduction products generated in such preparations markedly speed up discoloration in the models and apparently contribute to the improved clinical utility of the topical treatment by enhancing the speed and intensity of tissue fixation, but not tissue erosion. The architecture of lesions eradicated by such mixtures is generally adequately preserved for histologic diagnosis of the extruded tissue.
Asunto(s)
Evaluación de Medicamentos , Nitrocompuestos/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Administración Tópica , Método Doble Ciego , Combinación de Medicamentos , Femenino , Humanos , MasculinoAsunto(s)
Acetatos/uso terapéutico , Antineoplásicos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica , Carcinoma Basocelular/tratamiento farmacológico , Cobre/uso terapéutico , Fármacos Dermatológicos/uso terapéutico , Lactatos/uso terapéutico , Nitratos/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Ácido Acético , Combinación de Medicamentos/uso terapéutico , HumanosRESUMEN
Two cases of leishmaniasis recidivans of twenty years' duration were treated intravenously with sodium stibogluconate (Pentostam) with good results. Before treatment, histologic examination of a biopsy specimen revealed many Leishman-Donovan (LD) bodies. After treatment, repeated biopsies done in one of the cases revealed only scar tissue. We recommended treatment with sodium stibogluconate in cases of leishmaniasis recidivans, although an ideal treatment for this condition still does not exist.
Asunto(s)
Gluconato de Sodio Antimonio/uso terapéutico , Gluconatos/uso terapéutico , Leishmaniasis/tratamiento farmacológico , Compuestos Organometálicos , Adulto , Antibacterianos/uso terapéutico , Antimonio/uso terapéutico , Humanos , Leishmaniasis/diagnóstico , Leishmaniasis/patología , Masculino , Meglumina/uso terapéutico , Antimoniato de Meglumina , Persona de Mediana Edad , RecurrenciaRESUMEN
A case of generalized porokeratosis occurring in a man with primary hypoparathyroidism is reported herein. This, apparently, is the first reported case of these two disorders co-existing in a single patient. His porokeratotic skin changes were of wide morphologic and clinical variation and presented in the following forms: 1. Mibelli's plaque-type; 2. superficial disseminated eruptive-form; and 3. clavi-like lesions.
Asunto(s)
Hipoparatiroidismo/complicaciones , Queratodermia Palmoplantar/complicaciones , Adulto , Humanos , Queratodermia Palmoplantar/patología , MasculinoRESUMEN
We report here on the first epidemic of Microsporum canis infection in Israel. All 78 cases were diagnosed in the port city of Eilat between August, 1975 and May 1976. The epidemic has apparently been controlled with Griseofulvin therapy and public health measures.