RESUMEN

We report on the first Earth-scale quantum sensor network based on optical atomic clocks aimed at dark matter (DM) detection. Exploiting differences in the susceptibilities to the fine-structure constant of essential parts of an optical atomic clock, i.e., the cold atoms and the optical reference cavity, we can perform sensitive searches for DM signatures without the need for real-time comparisons of the clocks. We report a two orders of magnitude improvement in constraints on transient variations of the fine-structure constant, which considerably improves the detection limit for the standard model (SM)-DM coupling. We use Yb and Sr optical atomic clocks at four laboratories on three continents to search for both topological defect and massive scalar field candidates. No signal consistent with a DM coupling is identified, leading to considerably improved constraints on the DM-SM couplings.

RESUMEN

OBJECTIVE: Patients with critical limb ischaemia (CLI) lack sufficient blood flow in to the limb, which leads to difficulties in the normal wound healing process. Therefore, maggot debridement therapy (MDT) has not generally been recommended for CLI patients. We evaluated the effectiveness of wound bed preparation by MDT in CLI patients who had undergone mid-foot amputation. METHODS: Patients who underwent mid-foot amputation after angioplasty between April 2014 and October 2016 were retrospectively investigated by classifying them into an MDT group or a conventional treatment group. The primary outcome was defined as achievement of wound healing. Secondary outcomes were the proportions of amputation-free survival (AFS) and successful ambulatory improvement. Propensity scores were used to evaluate treatment outcomes based on five factors: ankle-brachial index, skin perfusion pressure of the foot, nutritional status, experience with dialysis and age. RESULTS: A total of 39 patients (39 legs) were included, seven within the MDT group and 32 in the conventional treatment group. Clinical backgrounds of the two groups showed no significant differences except for higher albumin levels for the MDT group (3.5±0.4g/dl; p=0.014). The wound healing proportion was significantly higher in the MDT group (86%) than in the control group (38%) (p=0.035). At 6 months after amputation, no significant differences were found between the two groups for AFS (71% versus 47%; p=0.41) or ambulatory capability (43% versus 28%; p=0.65). This result was also similar to the propensity score adjustment analysis. CONCLUSIONS: The efficacy of MDT with favourable wound bed preparation was shown in our CLI patients based on effective debridement and granulation formation by maggots, avoiding the loss of their heels. Wound-healing rates after MDT were higher for patients than for those receiving conventional treatment. MDT is considered a valid adjuvant treatment strategy for patients with CLI after revascularisation treatment is conducted. More favourable wound bed preparation and successful graft take were achieved in the MDT group, suggesting the effectiveness of MDT for wound healing in CLI patients.

Asunto(s)

Desbridamiento/métodos , Pie/cirugía , Isquemia/cirugía , Larva , Enfermedades Vasculares Periféricas/cirugía , Herida Quirúrgica/terapia , Anciano , Anciano de 80 o más Años , Amputación Quirúrgica , Angioplastia , Animales , Índice Tobillo Braquial , Procedimientos Endovasculares , Femenino , Pie/irrigación sanguínea , Tejido de Granulación , Humanos , Isquemia/complicaciones , Masculino , Persona de Mediana Edad , Enfermedades Vasculares Periféricas/complicaciones , Flujo Sanguíneo Regional , Estudios Retrospectivos , Albúmina Sérica , Piel/irrigación sanguínea , Herida Quirúrgica/complicaciones , Resultado del Tratamiento , Cicatrización de Heridas

RESUMEN

Soft tissue sarcomas of the head and neck region are rare, and very little has been described about the reconstructive methods used after sarcoma resection of cheek soft tissue sarcomas. Reconstructive methods for cheek defects after sarcoma resection are presented and the possibilities, advantages, disadvantages, and expected results are described. A series of 3 patients with cheek soft tissue sarcomas were examined. Reconstructive methods included; one skin graft, a free forearm flap and a cervicofacial flap. All patients had lesions < 5 cm and low-grade tumours, and no case presented local recurrence or metastases. The choice of reconstructive methods depends mostly on the complexity of the defect. In cases comprising comparatively small or minor defects, reconstructions using local flaps, such as the cervicofacial flap, provide better aesthetic and functional results than either free flaps or skin graft.

Asunto(s)

Mejilla , Neoplasias Faciales/cirugía , Procedimientos de Cirugía Plástica , Sarcoma/cirugía , Neoplasias de los Tejidos Blandos/cirugía , Adulto , Humanos , Masculino , Persona de Mediana Edad

RESUMEN

To obtain symmetric appearance in facial palsy patients, it is important to retain any remaining potential of the compromised facial mimetic muscles. The purpose of the present study was to introduce surgical rehabilitation based on neural signal augmentation/neural supercharge concept for the treatment of reversible facial palsy patients. With construction of facial-hypoglossal network system using end-to-side neurorrhaphy technique, both facial and hypoglossal motor signals are provided to the compromised facial mimetic muscles. It is hypothesised that the remaining potential of incompletely or completely paralysed muscles without atrophy is activated by a neural 'supercharge' effect. To date, nine patients presented with reversible facial palsy have been treated by surgical rehabilitation with facial-hypoglossal network system in our institutes. Facial mimetic muscle function evaluated by the House-Brackmann grading system was improved from grade IV-VI to II-III in this series. The postoperative ENMG findings showed double innervation of the mimetic muscles supplied by the facial and hypoglossal donor motor sources. Hemiglossal dysfunction and mimetic muscle synkinesis associated with tongue motion were never seen with an average follow-up period of 21 months after surgery. This reconstructive concept offers a significant advantage for the treatment of the facial palsy patients with persistent incomplete type and reversible complete type without distinct mimetic muscle atrophy.

Asunto(s)

Nervio Facial/cirugía , Parálisis Facial/cirugía , Nervio Hipogloso/cirugía , Adolescente , Adulto , Algoritmos , Electromiografía , Expresión Facial , Músculos Faciales/inervación , Músculos Faciales/fisiopatología , Parálisis Facial/etiología , Parálisis Facial/fisiopatología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Resultado del Tratamiento

RESUMEN

We report the successful surgical resolution of a case of massive esophago-tracheal fistula (ETF) caused by a stenting treatment for stricture of an esophago-gastric anastomosis. A 54-year-old man was admitted to our hospital due to serious pneumonia secondary to ETF. He had previously received esophagectomy and post-operative chemo-radiation therapy for esophageal cancer, followed by stenting treatments for a benign stricture of the esophago-gastric anastomosis. For surgical treatment of the resulting ETF, serial operations were required. The first operation, performed under percutaneous cardiopulmonary support, included removal of the stents followed by tracheotomy, were with the coverage of the tracheal defect achieved using both major pectoral muscle flaps. A salivary fistula was also generated and an enteral nutrition tube was placed. Six months after the first operation, a pedicled ileocolic interposition was performed in order to effect reconstruction of the digestive tube, with an additional microvascular anastomosis of the ileocolic and internal thoracic artery and vein. After the second operation, the patient's ability to ingest food was restored, and he was discharged from the hospital. Thus, ETF was successfully treated by successive surgical operations with delicate intra- and post-operative respiratory management.

Asunto(s)

Stents/efectos adversos , Fístula Traqueoesofágica/etiología , Fístula Traqueoesofágica/cirugía , Anastomosis Quirúrgica , Estenosis Esofágica/cirugía , Esófago/cirugía , Humanos , Masculino , Persona de Mediana Edad , Procedimientos de Cirugía Plástica , Estómago/cirugía

RESUMEN

AIM OF THE STUDY: A gastric tube is commonly used in thoracic esophageal reconstruction. When a gastric tube is not available, pedicled jejunum transfer and colonic interposition are alternative methods. Oral end of the reconstructed esophagus occasionally has poor blood flow and may result in partial necrosis of the oral segment. We performed additional microvascular blood flow augmentation, the "supercharge" technique, to improve a blood flow circulation in the oral segment of the reconstructed esophagus. METHODS: A series of 86 esophageal reconstructions with microvascular blood flow augmentation using the "supercharge" technique were performed. Reconstructive methods included a gastric tube in five patients, a gastric tube combined with a free jejunual graft in one, an elongated gastric tube in eight, a pedicled colonic interposition in 22, and a pedicled jejunum in 50. Recipient vessels were used in neck or chest region. RESULTS: The color and blood flow of the transferred intestine appeared greatly improved after microvascular blood flow augmentation. Thrombosis was noticed in three patients during the surgery, and all thrombosies were salvaged by re-anastomosis. There were only three patients with partial graft necrosis of oral segment, two patients with anastomotic leakage, one anastomotic stricture. CONCLUSIONS: Augmentation of microvascular blood flow by this "supercharge" technique can be expected to reduce the risk of leakage and partial necrosis of the transferred intestine. This technique contributes to the successful reconstruction of esophageal defect.

Asunto(s)

Esofagoplastia/métodos , Esófago/irrigación sanguínea , Faringe/cirugía , Procedimientos Quirúrgicos Vasculares/métodos , Adulto , Anciano , Femenino , Humanos , Yeyuno/trasplante , Masculino , Microcirculación , Microcirugia , Persona de Mediana Edad , Estómago/trasplante , Colgajos Quirúrgicos

RESUMEN

With the conventional techniques of tying knots during microvascular anastomosis or neural suturing, time may be lost due to various reasons. The loose end of the suture often falls down into the operative field and gets stuck to the surrounding tissues. In the process of retrieving the suture, the surrounding tissues can be picked up together with the suture. When the posterior wall technique [Br J Plast Surg 34 (1981) 47, Plast Reconstr Surg 69 (1982) 139, Microsurgery 8 (1987) 22, J Reconstr Microsurg 15 (1999) 321] is used, the loose end of the suture may be stuck to the backside of the vessel and may be hard to grab. In order to avoid those problems, a new way of tying a microsuture was developed. By avoiding contact of the loose end of the suture to the surrounding tissue at any point during tying, the microvascular anastomosis can be performed quicker and more efficiently.

Asunto(s)

Microcirugia/métodos , Técnicas de Sutura , Humanos

RESUMEN

The reaction of the activated olefins 1 with the allylic carbonate 2, having a hydroxy group at the terminus of the carbon chain, in the presence of catalytic amounts of Pd(2)dba(3).CHCl(3) and dppe in THF at room temperature gave the corresponding cycloaddition products, tetrahydrofuran derivatives 5, in good to very high yields. The diastereoselectivities (trans/cis ratios) of the products were in the range of ca. 60-70/40-30. The reaction of 1 with the hydroxy allylic carbonate 3 in the presence of catalytic amounts of Pd(2)dba(3).CHCl(3) and (o-tolyl)(3)P in THF at 50 degrees C afforded the corresponding cycloaddition products, tetrahydropyran derivatives 6, in good to high yields. The trans/cis ratios of the products were in the range of ca. 0-40/99-80. The reaction of 1a with the hydroxy allylic carbonate 4 needed higher reaction temperatures (approximately 100 degrees C) to give the cycloaddition product, the oxepane 7a, in 31% yield with low diastereoselectivity. Next, catalytic asymmetric syntheses of tetrahydrofuran and -pyran derivatives were carried out. With the Trost ligand 15, good to high ees were accomplished in the cycloaddition, although the diastereoselectivities were of low level. With the Hayashi ligand 16, good to high ees were also achieved in the cycloaddition. The absolute stereochemistries of the major enantiomers of 5l, 5m, and 6d were determined unambiguously by X-ray crystallographic analysis: trans-(2R,4R)-5l, cis-(2S,4R)-5l, 4R-5m, trans-(2S,4S)-6d, and cis-(2R,4S)-6d were major enantiomers. Based upon the absolute stereochemistries of the major enantiomers, the mechanism of catalytic asymmetric induction in the cycloaddition reaction is discussed.

RESUMEN

Early reperfusion and good antegrade flow are essential in restoring better regional left ventricular function in acute myocardial infarction, but they do not always correlate with the extent of recovery. This study evaluated coronary circulation using the new "pressure wire" technique to measure the direct pressure of the coronary circulation including antegrade and collateral flow before and after reperfusion in patients with acute myocardial infarction, and to clarify the influence of these variables on recovery of left ventricular function in the convalescent stage. Fifty six consecutive patients with first acute myocardial infarction underwent percutaneous transluminal coronary angioplasty(PTCA) for totally occluded or severely narrowed infarct-related lesion and evaluation of coronary circulation using pressure wire. Left ventriculography was analyzed at 1 month after the onset in 41 patients. Treatment variables including reperfusion time, reperfusion modality, Thrombolysis in Myocardial Infarction(TIMI) grade after PTCA, and pressure wire variables were compared with parameters of left ventricular function. Reperfusion time was not related to regional wall motion evaluated by the SD chord of left ventriculography in the infarcted zone. Pressure wire measurements showed a correlation between fractional flow reserve measured after PTCA and infarcted regional wall motion(r = 0.558, p < 0.01). Patients with infarct-related lesion in the right coronary artery showed the magnitude of left ventricular regional wall motion was related to fractional collateral flow reserve(maxQc/Qn) during PTCA(r = 0.768, p < 0.05), but no such relationship was observed in patients with infarct-related lesion in the left anterior descending artery. Fractional flow reserve measured after PTCA varied widely in patients with the same TIMI flow grade, so did not vary with it. The pressure wire technique enables assessment of the collateral circulation distal to infarct-related lesion quantitatively before reperfusion in patients with acute myocardial infarction. The fractional flow reserve derived by coronary pressure after reperfusion was significantly related to the recovery of regional wall motion in the infarcted area in the convalescent stage. The fractional flow reserve after reperfusion with PTCA is a better parameter than TIMI flow grade for predicting recovery of regional left ventricular function after myocardial infarction.

Asunto(s)

Presión Sanguínea/fisiología , Vasos Coronarios/fisiopatología , Infarto del Miocardio/fisiopatología , Disfunción Ventricular Izquierda/fisiopatología , Angioplastia Coronaria con Balón , Convalecencia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/terapia

RESUMEN

The authors report their experience with 80 head and neck reconstructions using free-tissue transfer in which end-to-side anastomosis with the internal jugular vein was carried out. An end-to-side anastomosis with the internal jugular vein has the following advantages. Firstly, the technique overcomes the problems of vessel size discrepancy. It is effectively applied for free jejunal transfer or combined flap transfer based on a single vascular pedicle, of which the size of the proximal end of the drainage vein is very large. Secondly, the internal jugular vein has wide capacity to be the recipient of two or more end-to-side anastomoses. It is effectively used for free radial forearm or rectus abdominis myocutaneous flaps in which two or more drainage veins can be included. Thirdly, the respiratory venous pump effect may act directly on the venous drainage of the transferred flap through the internal jugular vein. In our institution, these advantages have made it the technique of choice in head and neck reconstructive microsurgery.

Asunto(s)

Neoplasias de Cabeza y Cuello/cirugía , Venas Yugulares/cirugía , Microcirugia/métodos , Procedimientos de Cirugía Plástica/métodos , Colgajos Quirúrgicos/irrigación sanguínea , Adulto , Anciano , Anastomosis Quirúrgica/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad

RESUMEN

Infective endocarditis still presents problems with early diagnosis, selection of antibiotics and timing of surgical procedure despite modern antibiotics and investigative procedures. A retrospective study was performed to clarify the clinical and microbiological spectrum of recent infective endocarditis in the Japanese population in 38 patients with infective endocarditis (mean age 42.7 +/- 12.5 years) treated from March 1986 to March 1996. The portal of entry to bacteremia was unknown in most cases (57.9%), but the commonest identified portal was dental procedure (18.4%). Overall, the aortic valve was infected most frequently (44.7%) and followed by the mitral valve (36.8%). The most common complication of infective endocarditis were emboli (11/38, 28.9%) and congestive heart failure, NYHA class III and IV (14/38, 36.8%). Organisms were isolated from 26 of the 38 (68.4%) patients. Streptococcus viridans was the most frequent organism (34.2%), and then Staphylococcus aureus (13.2%). The blood culture positivity of microorganism was significantly higher in patients not receiving antibiotics than in those the received antibiotics (87.5% vs 50%, p < 0.05). The prevalence of streptococcal endocarditis decreased in the 1990s (1992-1996) in comparison with those in the 1980s (1986-1988). Multiple antibiotics were used frequently in 1990s and the sensitivity titer to piperacillin reduced from 3.0 in the 1980s to 1.8 in the 1990s. In contrast to reduction of streptococcal endocarditis, Staphylococcus aureus endocarditis has increased recently from 12.5% to 30.8%. The most common clinical features are valve destruction, low sensitivity of penicillin, and significantly higher in-hospital mortality. Surgical treatment was indicated most commonly in cases of uncontrollable heart failure, and infected valves were replaced during the active stage in 11/23 cases (47.8%). In-hospital mortality was higher in the medical treatment group than in the surgical group, but a long-term mortality of mean observation term 4.2 +/- 3.2 years was identical in the chronic phase. In patients with infective endocarditis and successful treatment in the acute stage, a long-term survival rate in medically treated patients was found almost comparable to surgically treated patients in our series. However, it should be emphasized that streptococcal endocarditis is being replaced by infection by Staphylococcus aureus, which is resistant to penicillin and requires intensive chemotherapy and proper decision at suitable timing for surgical therapy in the early stage.

Asunto(s)

Endocarditis Bacteriana/microbiología , Adulto , Antibacterianos/uso terapéutico , Válvula Aórtica/microbiología , Farmacorresistencia Microbiana , Embolia/complicaciones , Endocarditis Bacteriana/epidemiología , Endocarditis Bacteriana/terapia , Femenino , Insuficiencia Cardíaca/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Válvula Mitral/microbiología , Prevalencia , Infecciones Estafilocócicas/epidemiología , Staphylococcus aureus/aislamiento & purificación , Infecciones Estreptocócicas/epidemiología , Streptococcus/aislamiento & purificación

RESUMEN

The free or pedicled anterolateral thigh flap was introduced for the reconstruction of large abdominal wall defects. This flap is superior to the tensor fasciae latae musculocutaneous flap in several respects. These include the wide, reliable skin territory (which can reach the level of the knee) and the long pedicle. Therefore, a pedicled anterolateral thigh flap with reliable blood circulation can easily be positioned above the umbilicus. In addition, the free anterolateral thigh flap has greater freedom of orientation and can be used to repair larger abdominal wall defects than can the tensor fasciae latae flap. Seven patients in whom abdominal wall defects had been reconstructed with pedicled or free anterolateral thigh flaps were reviewed. Their average age was 47.1 years (range, 21 to 74 years), and the average follow-up period was 10.7 months (range, 2 to 21 months). The size of the abdominal wall defects ranged from 12 x 12 cm to 18 x 24 cm, and the size of the transferred flap ranged from 10 x 20 cm to 20 x 20 cm. Three flaps were pedicled and four were free, of which three incorporated the tensor fasciae latae flap. All flaps survived completely, and no postoperative abdominal hernias developed. Despite some variations in vascular anatomy and technical difficulties in elevating the anterolateral thigh flap, the authors conclude that the pedicled or free anterolateral thigh flap is superior to the tensor fasciae latae flap for reconstruction of large abdominal wall defects.

Asunto(s)

Músculos Abdominales/cirugía , Procedimientos de Cirugía Plástica/métodos , Colgajos Quirúrgicos , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de los Músculos/secundario , Neoplasias de los Músculos/cirugía , Muslo/cirugía

RESUMEN

The authors describe a case in which a large defect of the scalp was present after tumor excision. It was covered with a free adipofascial flap and a split-thickness skin graft, with satisfactory results. Numerous similar cases of scalp defects reconstructed with other free flaps have been described. But since donor-site morbidity is minimized with free adipofascial flaps, they should be used more often for reconstruction of scalp defects.

Asunto(s)

Tejido Adiposo/trasplante , Fascia/trasplante , Cuero Cabelludo/cirugía , Colgajos Quirúrgicos , Anciano , Cicatriz/cirugía , Femenino , Estudios de Seguimiento , Hemangiosarcoma/cirugía , Humanos , Neoplasias Cutáneas/cirugía , Trasplante de Piel/métodos , Cicatrización de Heridas

Asunto(s)

Aneurisma de la Aorta Torácica/diagnóstico , Disección Aórtica/diagnóstico , Enfermedad Aguda , Adulto , Disección Aórtica/cirugía , Aorta/cirugía , Aorta Torácica/cirugía , Aneurisma de la Aorta Torácica/cirugía , Válvula Aórtica/cirugía , Implantación de Prótesis Vascular , Diagnóstico Diferencial , Ecocardiografía Transesofágica , Implantación de Prótesis de Válvulas Cardíacas , Humanos , Masculino , Persona de Mediana Edad , Tomografía Computarizada por Rayos X

RESUMEN

3-(o-Carboranylhydroxymethyl)-7-isopropylazulene sodium carboxylate (1) and 3-(o-carboranylmethyl)-7-isopropylazulene sodium sulfonate (2) were synthesized from the palladium-catalyzed addition reaction of 1-carboranyltributylstannane (4) to azulene aldehydes (3 and 9). Although the water solubility of 1 was of the order of 10(-6) M, that of 2 was of the order of 10(-3) M and was enough for clinical use. The cytotoxicity of 1 (IC50) toward B-16 melanoma cells was of the order of 10(-5) M, whereas that of 2 was of the order of 10(-4) M. This value was close to that of BPA (approximately 9 x 10(-3) M) which is utilized for clinical use. The boron uptake by B-16 cells was 0.17 microgram of B/10(6) cells for 1 and 0.25 microgram of B/10(6) cells for 2. It is clear that compound 2 accumulates in B-16 melanoma cells with a significantly high level although it is highly water soluble and its cytotoxicity is significantly low.

Asunto(s)

Antiinflamatorios no Esteroideos/química , Antineoplásicos/síntesis química , Compuestos de Boro/síntesis química , Boro/administración & dosificación , Cicloheptanos/química , Ciclopentanos/síntesis química , Melanoma Experimental/metabolismo , Animales , Antineoplásicos/química , Antineoplásicos/toxicidad , Azulenos , Boro/farmacocinética , Compuestos de Boro/química , Compuestos de Boro/toxicidad , Terapia por Captura de Neutrón de Boro , Supervivencia Celular/efectos de los fármacos , Ciclopentanos/química , Ciclopentanos/toxicidad , Portadores de Fármacos , Ensayos de Selección de Medicamentos Antitumorales , Ratones

RESUMEN

Microsurgical reconstruction of abdominal or chest-wall defects requires extreme precision but may still raise serious problems. In previous publications many methods have been reported, including free fascia graft, synthetic mesh, pedicled flap, and free flap with microvascular anastomoses. Free-flap transfer has become a popular operative procedure for such reconstructions. The recipient vessels utilized have been mainly the external peritoneal system. In some cases, however, it is very difficult to find adequate recipient vessels in the external peritoneal region. Intraperitoneal vessels may be obviously exposed in the surgical field because there has been a full-thickness defect of the abdominal or chest wall. These vessels are rather easily found and dissected. Their diameter is about 1 to 2 mm, appropriate for microvascular anastomoses with flap vessels in the reconstruction. Using intraperitoneal vessels for the recipient vessels has rarely been reported. The authors report three cases of reconstruction of full-thickness defects of the abdominal or chest wall, using these vessels as recipients for free flaps.

Asunto(s)

Músculos Abdominales/cirugía , Complicaciones Posoperatorias/cirugía , Colgajos Quirúrgicos , Cirugía Torácica , Abdomen/cirugía , Músculos Abdominales/patología , Anciano , Carcinoma/secundario , Carcinoma/cirugía , Humanos , Masculino , Persona de Mediana Edad , Neoplasias del Colon Sigmoide/cirugía , Neoplasias Cutáneas/cirugía

RESUMEN

We investigated the role of myocardial ischemia in acute myocardial infarction and cardiac death in 253 patients with asymptomatic coronary disease (206 men, 47 women, mean age: 55 +/- 8 years). Patients were divided into two groups: those with angina pectoris with no history of myocardial infarction (AP group, 93 patients) and those with a history of myocardial infarction (MI group, 160 patients). We also examined the usefulness of exercise electrocardiographic and Holter electrocardiographic findings as prognostic indicators of cardiac events. After 24-hour Holter electrocardiograms were obtained in both groups, patients were assigned to subgroups with or without silent myocardial ischemia (SMI) based on the presence or absence of transient ST-segment depression. Prognostic indicators were evaluated by multiple regression analysis. Cardiac events occurred in 26 (10.3%) of 253 patients; in 6 patients these events were fatal. The incidence of cardiac events was significantly higher in the SMI group than in the non-SMI group (16.4% versus 5.6%, p < 0.05). SMI was identified as a significant prognostic indicator in the overall population (p = 0.0088), as were the number of diseased coronary arteries in the AP group (p = 0.0152), and SMI (p = 0.0022) in the MI group. There were 3 deaths related to cardiac events in each group. The mean time from onset of angina pectoris to death was 73 +/- 41 months compared with 33 +/- 43 months in the MI group. Our findings suggest that the severity of the coronary lesion and SMI were important predictors of major cardiac events, and that the mechanism of the onset of cardiac events was different in the AP and MI groups.

Asunto(s)

Enfermedad Coronaria/complicaciones , Muerte Súbita Cardíaca/etiología , Infarto del Miocardio/complicaciones , Adulto , Anciano , Angina de Pecho/complicaciones , Angina de Pecho/fisiopatología , Enfermedad Coronaria/fisiopatología , Electrocardiografía , Electrocardiografía Ambulatoria , Prueba de Esfuerzo , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/fisiopatología , Pronóstico

RESUMEN

Full skin thickness burns covering 35 per cent of the total body surface of rabbits were followed by measurements of Na-K ATPase and arterial blood gas analyses, before and after the burn injury. Studies of the effects of intravenous fluids with different compositions showed that the active transport of the cell membrane was depressed in vivo immediately after a burn injury, mainly due to acidosis. This phenomenon was not completely corrected by the Baxter formula which uses conventional lactated Ringer's solution. However, an improvement was observed in those groups given the 'Enriched Lactate Solution' (ELS) containing large quantities of lactate as the base source. These results suggest that ELS, which positively corrected acidosis in accordance with its concentration, is very effective and more appropriate than the conventional lactated Ringer's solution for early burn resuscitation.

Asunto(s)

Quemaduras/terapia , Fluidoterapia , Soluciones Isotónicas/administración & dosificación , Lactatos/administración & dosificación , Resucitación , Acidosis/terapia , Animales , Análisis de los Gases de la Sangre , Infusiones Intravenosas , Conejos , Lactato de Ringer , ATPasa Intercambiadora de Sodio-Potasio/análisis

Asunto(s)

Fracturas Óseas , Osteogénesis Imperfecta , Humanos

Asunto(s)

Fibroma , Neoplasias Maxilares , Humanos