RESUMEN
A 69-year-old man with liver cirrhosis presented to a surgeon, complaining of pain and swelling involving the right knee joint. A cloudy yellow synovial fluid was aspirated. The examination revealed polymorphonuclear leukocytes and Listeria monocytogenes was grown in the culture. The patient was treated with oral cotrimoxazole. Further follow-up was uneventful. The literature on listerial joint infections is briefly reviewed.
Asunto(s)
Artralgia/diagnóstico , Artralgia/etiología , Artritis Infecciosa/complicaciones , Artritis Infecciosa/diagnóstico , Listeriosis/complicaciones , Listeriosis/diagnóstico , Anciano , Diagnóstico Diferencial , Humanos , MasculinoRESUMEN
M. malmoense could be cultivated in sputum samples of a 49-year-old patient with destructive pulmonary disease. The conventional antituberculous therapy (started because initially a presumptive diagnosis of tuberculosis was established) was altered to ethambutol, rifabutin, clarithromycin and ciprofloxacin, followed by a long-time therapy with azithromycin or clarithromycin. But till now it was not possible to eradicate the mycobacteria from the respiratory tract (insufficient compliance, interruptions of the therapy due to side effects, excessive smoking). Infections due to M. malmoense are rare events. Many patients have disposing underlying diseases. In most cases it is a pulmonary infection. The most frequent used antibiotics are rifampicin (or rifabutin), ethambutol and clarithromycin.
Asunto(s)
Quimioterapia Combinada/uso terapéutico , Enfermedades Pulmonares/tratamiento farmacológico , Infecciones por Mycobacterium no Tuberculosas/tratamiento farmacológico , Azitromicina/uso terapéutico , Claritromicina/uso terapéutico , Etambutol/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Infecciones por Mycobacterium no Tuberculosas/diagnóstico , Rifampin/uso terapéuticoRESUMEN
Interaction of polymers with cell surfaces is a question of general interest for cell aggregation and fusion. The molecular dynamics within the surface coat of human erythrocytes as well as alterations of membrane protein arrangement (IMPs) in the presence of poly(ethylene glycol) (PEG) were investigated by EPR spin labeling techniques and freeze-fracture electron microscopy, respectively. AT PEG concentrations which induce aggregation of erythrocytes the surface coat and the protein arrangement is not disturbed by the polymer. This implicate an exclusion of the polymer from the cell surface.