RESUMEN
The posttraumatic pneumatocele is a rare intrapulmonary lesion following blunt thoracic injury. By means of a well documented case report this rare form of lung contusion is demonstrated and the clinically important differential diagnosis is discussed.
Asunto(s)
Quistes/diagnóstico , Lesión Pulmonar , Heridas no Penetrantes/diagnóstico , Adulto , Contusiones/diagnóstico , Femenino , Hematocele/diagnóstico , Humanos , MasculinoAsunto(s)
Perineo/cirugía , Neoplasias del Recto/cirugía , Cicatrización de Heridas , Anciano , Terapia Combinada , HumanosRESUMEN
A multicentric, double-blind, randomized, parallel-group study was performed in patients with fever of diverse origin to test the tolerance and the antipyretic activity of single oral doses of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) (200 mg, n = 18), acetylsalicylic acid (ASA) (1000 mg, n = 22) and placebo (n = 19). Whereas with placebo mean rectal temperature remained constant, a continuous fall was recorded with both active medications over the whole 3-h study period. With fluproquazone normalization of body temperature was nearly reached. Fluproquazone was more effective than placebo (p less than 0.001) and ASA (p less than 0.1), which in turn was more active than placebo (p less than 0.0001). No specific side-effects occurred.
Asunto(s)
Antiinflamatorios no Esteroideos , Fiebre/tratamiento farmacológico , Quinazolinas/uso terapéutico , Adulto , Aspirina/uso terapéutico , Temperatura Corporal , Femenino , Fiebre/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , QuinazolinonasRESUMEN
In 4 double-blind, randomized, stratified, parallel group studies, single oral doses of fluproquazone (75 to 200 mg), a new nonsteroidal anti-inflammatory analgesic, were compared with aspirin (1,000 mg) and placebo in a total of 672 hospitalized patients with moderate or severe pain following episiotomy or other surgical interventions. A dose-dependent effect of fluproquazone which was highly significantly superior to placebo and which resembled the effect of aspirin with respect to onset, degree, and duration was noted in all studies. Fluproquazone, 100 to 150 mg, was found to be approximately equiactive to 1,000 mg of aspirin and better tolerated.
Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Dolor Postoperatorio/tratamiento farmacológico , Quinazolinas/uso terapéutico , Adulto , Antiinflamatorios no Esteroideos/efectos adversos , Aspirina/uso terapéutico , Ensayos Clínicos como Asunto , Relación Dosis-Respuesta a Droga , Episiotomía , Femenino , Humanos , Masculino , Persona de Mediana Edad , QuinazolinonasRESUMEN
Both chenodeoxycholic acid, in the dosage administered for dissolution of gallstones, and cholic acid are completely conjugated during one passage through the liver. The glycine:taurine ratio increases with the cumulative amount of exogenous bile acids secreted, which suggests consumption of available taurine. Since conjugation with glycine compensates for deficiency of the taurine conjugating system, it can be assumed that in the normal liver and with doses not exceeding 2.5 mmoles, chenodeoxycholic acid is efficiently and completely transformed into its "physiologic" conjugated form.